Manufacturer: Mylan Pharmaceuticals Pvt Ltd
Salt Composition : Trastuzumab(150mg)
Hertraz 150mg Injection is used in the treatment of breast and stomach cancer. It works by killing the cancer cells by inhibiting HER2 (human epidermal growth factor receptor protein).
Hertraz 150mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, headache, rash, insomnia, and infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You must have to inform your doctor if you experience breathlessness, cough, shivering, swelling of legs and arm.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Trastuzumab binds to an extracellular domain of this receptor and inhibits HER2 homodimerization, thereby preventing HER2-mediated signaling. It is also thought to facilitate antibody-dependent cellular cytotoxicity, leading to the death of cells that express HER2.
Trastuzumab pharmacokinetics are characterized by a low systemic clearance, a low volume of distribution (4l) and a very long half-life (28 days) comparable to that of endogenous immunoglobulins G. The elimination pathways are not yet defined and the clinical relevance of trastuzumab kinetic variability is unknown
Anemia (low number of red blood cells)
Chills
Common cold
Cough
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea
Fatigue
Fever
Headache
Heart failure
Infection
Insomnia (difficulty in sleeping)
Mucosal inflammation
Nausea
Rash
Stomatitis (Inflammation of the mouth)
Taste change
Upper respiratory tract infection
Weight loss
Contraindications for trastuzumab treatment include a history of hypersensitivity to trastuzumab treatment or murine proteins, severe dyspnea at rest resulting from complications of advanced malignancy, and requiring supplementary oxygen therapy
Hertraz 150mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Hertraz 150mg Injection may cause excessive drowsiness with alcohol.
Hertraz 150mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
HER2-positive breast cancer: adjuvant therapy - Approved for combination use with anthracycline- or taxane-based chemotherapy. ...
Metastatic HER2-positive breast cancer - Approved as monotherapy or for combination use with paclitaxel.
Synergistic interactions at clinically relevant drug concentrations were observed for trastuzumab in combination with cisplatin, docetaxel, thiotepa, 4-OH cyclophosphamide, vinorelbine, and etoposide. Additive cytotoxic effects were observed with trastuzumab plus doxorubicin, paclitaxel, methotrexate, and vinblastine
Your doctor or nurse will give you this medicine
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Hertraz 150mg Injection, please consult your doctor.
Consult a doctor before taking any medicines
It is given as an injection into your vein or under the skin, usually over 1 hour.
Use effective contraception method to prevent pregnancy while taking this medicine and for 7 months after you stop the treatment.
Your doctor will monitor your heart regularly while taking this medicine. Inform your doctor if you notice symptoms such as breathlessness, cough, shivering, swelling of legs and arm.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What are the serious side effects of Hertraz 150mg Injection?
There are various side effects related to Hertraz 150mg Injection such as sore throat, fever, chills, excessive tiredness, pale skin, nosebleeds, and other unusual bruising or bleeding. One can also experience stomach pain, seizures, hallucinations, muscle cramps, and spasms. Along with that, nausea or vomiting, loss of appetite, fatigue, rapid heart beat, discoloration of urine; decreased amount of urine, difficulty in urinating, pain when urinating, and other signs of infection can also be observed with the use of Hertraz 150mg Injection. You should call your doctor immediately if you notice any such symptoms.
Q. How long after Hertraz 150mg Injection therapy can I get pregnant?
Women of child-bearing age should use effective contraception during Hertraz 150mg Injection therapy and for 7 months after completing the treatment. You can plan your pregnancy after 7 months of treatment with Hertraz 150mg Injection.
Q. How long should Hertraz 150mg Injection be taken?
Patients with early breast cancer should take Hertraz 150mg Injection for 1 year or until disease recurs, whichever occurs first. It is not advised to extend the treatment beyond 1 year in patients of early breast cancer.
Q. Is fasting required before administering Hertraz 150mg Injection?
No, fasting is not required before administering Hertraz 150mg Injection. It should be given under the guidance of a doctor who is experienced in giving cancer chemotherapy and should be given only by a healthcare professional.
