Manufacturer: Zydus Cadila
Salt Composition : Ifosfamide(500mg)
Vial of 1 Injection
(Inclusive of all taxes)
Holoxan 500mg Injection is usually given as a slow infusion (drip) into a vein (intravenously) over several hours. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.
The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells), hair loss, decreased white blood cells count. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys.
Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped.
Holoxan 500mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
Ifosfamide is a prodrug that requires biotransformation to become cytotoxic. It is a structural isomer of cyclophosphamide from which it differs only in having the chlorethyl functions on different nitrogen atoms. This causes a considerable change in initial metabolism, although overall metabolism remains the same.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Holoxan
Nausea
Vomiting
Anemia (low number of red blood cells)
Hair loss
Decreased white blood cell count
Infection
Blood in urine
CNS toxicity
Ifosfamide is avoided in severe thrombocytopenia and leukopenia cases due to its well-documented hematological toxicity. Ifosfamide is contraindicated in cases of severe renal and hepatic impairment, as it is metabolized by the liver and eliminated by the kidneys.
Holoxan 500mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Holoxan 500mg Injection.
Holoxan 500mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Ifosfamide is an alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
Drug-Drug Interactions: IFOSFAMIDE may interact with live attenuated vaccines, TNF- blockers (etanercept, adalimumab), antifungal (fluconazole, itraconazole, ketoconazole); antiepileptic ( carbamazepine, phenytoin, phenobarbital), antihypertensive (diltiazem, enalapril), antibiotic (amphotericin-B, rifampin), antipsychotics (clozapine), anti-metabolites (cisplatin).
Drug-Food Interactions: IFOSFAMIDE may interact with grapefruit, st. John's wort and alcohol increase the risk of side effects.
Drug-Disease Interactions: IFOSFAMIDE should be used with caution in patients with heart diseases, liver diseases, kidney diseases, bone marrow suppression, CNS toxicity, cystitis, and infections.
Drug-Drug Interactions Checker List:
CISPLATIN
AMPHOTERICIN B
RIFAMPIN
DILITAZEM
ENALAPRIL
CLOZAPINE
CARBAMAZEPINE
PHENYTOIN
PHENOBARBITAL
FLUCONAZOLE
ITRACONAZOLE
KETOCONAZOLE
ETANERCEPT
ADALIMUMAB
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Holoxan 500mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Holoxan 500mg Injection is used in combination with other chemotherapy medicines, radiotherapy and surgery to treat cancer of blood, breast, lung, ovaries, pancreas, testes, and lymph nodes.
It is usually given as a slow infusion (drip) into a vein (intravenously) over several hours.
Drink plenty of fluids while taking this medication to minimise damage to your bladder and kidneys.
It may cause dizziness and sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you.
Use effective measures to avoid pregnancy during treatment with this medicine and for at least 6 months after your last dose as it can be harmful to an unborn baby.
Your doctor may have your blood tested regularly to monitor your kidney, liver function and levels of blood cells in your blood.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
