Manufacturer: Parenteral Drugs India Ltd
Salt Composition : Ifosfamide(2gm)
It is used in the treatment of blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer (a type of cancer that begins in the ovaries), testicular cancer (cancer occurs in the testicles (testes), (which are located inside the scrotum, a loose bag of skin underneath the penis), and pancreatic cancer (a type of cancer that begins in the pancreas). Blood cancer begins in blood-forming tissue, such as the bone marrow or the immune system's cells. Examples of blood cancer are leukemia ( a blood cancer caused by a rise in the number of white blood cells in your body), lymphoma (cancer that begins in infection-fighting cells of the immune system, called lymphocytes), and multiple myeloma (cancer that forms in a type of white blood cell called a plasma cell).
Ifosfamide contains ‘ifosfamide’, which is an anti-cancer drug. It is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer. Ifosfamide works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication
Ifosfamide is a prodrug that requires biotransformation to become cytotoxic. It is a structural isomer of cyclophosphamide from which it differs only in having the chlorethyl functions on different nitrogen atoms. This causes a considerable change in initial metabolism, although overall metabolism remains the same.
Nausea
Vomiting
Anemia (low number of red blood cells)
Hair loss
Decreased white blood cell count
Infection
Blood in urine
CNS toxicity
Dehydration
Dry mouth/increased thirst
Pale/wrinkled skin
Temporary hair loss
Trouble breathing
Ifosfamide is avoided in severe thrombocytopenia and leukopenia cases due to its well-documented hematological toxicity. Ifosfamide is contraindicated in cases of severe renal and hepatic impairment, as it is metabolized by the liver and eliminated by the kidneys.
Ifosfamide is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this Ifosfamide
Consumption of alcohol is not recommended while receiving this Ifosfamide as it may increase the risk of adverse effects such as dizziness, drowsiness, abnormal muscle movements, seizures.
Ifosfamide is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition
Ifosfamide is an alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
Drug-Drug Interactions: IFOSFAMIDE may interact with live attenuated vaccines, TNF- blockers (etanercept, adalimumab), antifungal (fluconazole, itraconazole, ketoconazole); antiepileptic ( carbamazepine, phenytoin, phenobarbital), antihypertensive (diltiazem, enalapril), antibiotic (amphotericin-B, rifampin), antipsychotics (clozapine), anti-metabolites (cisplatin).
Drug-Food Interactions: IFOSFAMIDE may interact with grapefruit, st. John's wort and alcohol increase the risk of side effects.
Drug-Disease Interactions: IFOSFAMIDE should be used with caution in patients with heart diseases, liver diseases, kidney diseases, bone marrow suppression, CNS toxicity, cystitis, and infections.
Drug-Drug Interactions Checker List:
CISPLATIN
AMPHOTERICIN B
RIFAMPIN
DILITAZEM
ENALAPRIL
CLOZAPINE
CARBAMAZEPINE
PHENYTOIN
PHENOBARBITAL
FLUCONAZOLE
ITRACONAZOLE
KETOCONAZOLE
ETANERCEPT
ADALIMUMAB
Store below 30°C
Consult a doctor before taking any medicines.
Consult a doctor before taking any medicines.
Ifosfamide is available in the form of injection. Ifosfamide should be taken as advised by your doctor. Kindly do not self-administer. Your doctor or nurse will give you this medicine
