Manufacturer: Emcure Pharmaceuticals Ltd
Salt Composition : Irinotecan(100mg)
Imtus 100mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include fatigue, nausea, vomiting, weakness, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Imtus 100mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
The clinical pharmacokinetics of irinotecan (CPT11) can be described by a 2 or 3 compartment model, a mean terminal half-life of 12 hours, a volume of distribution at steady state of 168 l/m2 and a total body clearance of 15 l/m2/h. Irinotecan is 65% bound to plasma proteins.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Imtus
Fatigue
Nausea
Vomiting
Weakness
Hair loss
Fever
Anemia (low number of red blood cells)
Diarrhea
Decreased white blood cell count (neutrophils)
Decreased appetite
Mucosal inflammation
Contraindications to irinotecan would involve severe allergic reactions to its group of chemotherapeutic agents, the DNA topoisomerase I inhibitors. Irinotecan is contraindicated in gastric cancer patients with peritoneal metastasis or impaired liver function.
Imtus 100mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Imtus 100mg Injection. Please consult your doctor.
Imtus 100mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Irinotecan is used alone or in combination with other medications to treat colon or rectal cancer (cancer that begins in the large intestine). Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells.
Drug-Drug Interactions: IRINOTECAN may interact with macrolide antibiotics (e.g. clarithromycin, erythromycin), medicines used to treat high blood pressure and to control angina (e.g. diltiazem), anti-fungal medications (e.g. itraconazole, ketoconazole) and HIV/AIDS medications (e.g. ritonavir).
Drug-Food Interactions: Avoid the consumption of alcoholic beverages and grapefruit juices.
Drug-Disease Interactions: IRINOTECAN may interact with disease conditions, including severe renal or hepatic conditions, severe diarrhoea, bone marrow suppression, Neutropenia (An abnormally low count of a type of white blood cell), and pulmonary toxicity.
Drug-Drug Interactions Checker List:
CLARITHROMYCIN
ERYTHROMYCIN
DILTIAZEM
ITRACONAZOLE
KETOCONAZOLE
RITONAVIR
Kindly do not self administer.
Store below 30°C
If you miss a dose of Imtus 100mg Injection, please consult your doctor.\n
Consult a doctor before taking any medicines.
Imtus 100mg Injection is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.
It is given via a drip into a vein (intravenous infusion).
It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
