Manufacturer: Lupin Ltd
Salt Composition : Isosorbide Dinitrate(20mg), Hydralazine(37.5mg)
Isolazine Tablet should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like a low-fat diet, exercise, and not smoking may help this medicine to work better.
It is generally safe and suitable for most people but has some potential side effects. The most common side effects of this medicine include nausea, vomiting, diarrhea, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes you feel dizzy as of orthostatic hypotension (sudden lowering of blood pressure on standing). Hence, rise slowly while from a sitting position or avoid driving. You may be asked for regular monitoring of blood pressure while on the treatment.
Before taking this medicine, tell your doctor if you have liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Isolazine Tablet is a combination of two medicines: Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate is a nitrate which relaxes the blood vessels and decreases the oxygen demand of the heart. Hydralazine is a potassium channel opener which acts as an antioxidant and lessens tolerance to isosorbide dinitrate, thereby preserving its capacity to relax blood vessels. Together, they improve symptoms of heart failure.
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter.hydralazine is absorbed well from the gastrointestinal tract, and has an extensive and complex metabolism depending on acetylator status: slow acetylators undergo primary oxidative metabolism, while rapid acetylators are acetylated.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Isolazine
Headache
Dizziness
Serve side effects of Isolazine
Enlarged spleen
Erectile dysfunction
Paralytic ileus
Difficulty in urination
Alcohol
Allergic reactions
Anemia
Avanafil
Brain hemorrhage
Coronary artery disease
Head injury
Heart attack
Low blood pressure
Mitral valvular rheumatic heart disease
Isolazine Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol while taking Isolazine Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Isolazine Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Isosorbide Dinitrate+Hydralazine is used in the treatment of Heart failure.Isosorbide dinitrate is a nitrate which relaxes the blood vessels and decreases the oxygen demand of the heart. Hydralazine is a potassium channel opener which acts as an antioxidant and lessens tolerance to isosorbide dinitrate, thereby preserving its capacity to relax blood vessels. Together, they improve symptoms of heart failure.
Avanafil
Diazoxide
Dihydroergotamine
Dihydroergotoxine
Ergonovine
Hypotensives
Methylergonovine
NSAIDs
Oestrogens
Sildenafil
Do not chew, crush or break it. Isolazine Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Isolazine Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Isolazine Tablet is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
Isolazine Tablet may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
It is best to avoid drinking alcohol while taking Isolazine Tablet as it may make the side effects worse.
Do not take it in combination with medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.
Do not stop taking Isolazine Tablet suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isolazine Tablet is to be taken with food.
Q. Can I stop taking Isolazine Tablet if I feel well?
No, keep using Isolazine Tablet as advised by your doctor, even if you feel well. Stopping Isolazine Tablet suddenly may lead to serious complications of heart failure.
Q. Are there any special instructions regarding storage and disposal of this medicine?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can the use of Isolazine Tablet cause headache?
Isolazine Tablet can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.
Q. Can the use of Isolazine Tablet cause dizziness?
Yes, the use of Isosorbide Isolazine Tablet can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
