Manufacturer: Ipca Laboratories Ltd
Salt Composition : Isosorbide Dinitrate(10mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Isordil 10 Tablet should be taken on an empty stomach. It is best taken at the same time every day. Your doctor will decide the dose and the number of times each day you should take them. You should take the medicine as it is prescribed for you and keep taking it, even if you feel well. If you stop taking it suddenly your risk of an angina attack will increase. Lifestyle changes such as diet, exercise, and not smoking may help this drug work better.
You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
The most common side effects of this medicine include headache and lightheadedness. These may disappear once you have got used to the medicine. If you are worried, or the symptoms do not go away, let your doctor know. Some of these can be reduced by taking painkillers, drinking plenty of fluids, and avoiding alcohol. Alcohol may increase some side effects (dizziness, drowsiness, feeling light-headed, or fainting). Medical tests (such as blood pressure) may be required to monitor your progress and check for side effects.
Isordil 10 Tablet is a nitrate. It works by relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload. It thus prevents/treats attacks of angina (chest pain).
Once absorbed, the volume of distribution of isosorbide dinitrate is 2 to 4 L/kg, and this volume is cleared at the rate of 2 to 4 L/min, so ISDN's half-life in serum is about an hour. Since the clearance exceeds hepatic blood flow, considerable extra hepatic metabolism must also occur.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Isordil
Headache
Allergic to nitrates.
Concomitant use of isosorbide with PDE inhibitors such as sildenafil and tadalafil.
Concomitant use of isosorbide with riociguat, a soluble guanylate cyclase stimulator used for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension[24]
Isordil 10 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consuming alcohol while taking Isordil 10 Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Isordil 10 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
FDA Approved Indications for Isosorbide Dinitrate
Prevention or treatment of angina pectoris resulting from coronary artery disease - however, it is not recommended for use once the anginal episode has started because the onset of action is not sufficiently rapid enough to abort an acute anginal event.
Drug-Drug interactions: ISOSORBIDE DINITRATE should not be used with organic nitrate drugs used to treat erectile dysfunction (sildenafil, vardenafil, tadalafil, and avanafil) and medicine used to treat pulmonary hypertension (riociguat), medicines to treat high blood pressure (norepinephrine), phenothiazines, and antiallergic medications.
Drug-Food interactions: Intake of foods containing high amounts of sodium should be reduced.
Drug-Disease interactions: ISOSORBIDE DINITRATE use is contraindicated in conditions such as acute myocardial infarction or congestive heart failure, severe hypotension (low blood pressure), severe anemia, bleeding in the brain, and severe dehydration.
Drug-Drug Interactions Checker List:
TADALAFIL
SILDENAFIL
VARDENAFIL
AVANAFIL
RIOCIGAUT
NOREPINEPHRINE
Do not chew, crush or break it. Isordil 10 Tablet is to be taken empty stomach.
Store below 30°C
If you miss a dose of Isordil 10 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n
Consult a doctor before taking any medicines.
Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
Isordil 10 Tablet may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
Do not consume alcohol while taking Isordil 10 Tablet as it may cause increased dizziness.
It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
You may develop tolerance to Isordil 10 Tablet with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Isordil 10 Tablet as it may cause low blood pressure.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isordil 10 Tablet is to be taken empty stomach.
Q. What is Isordil 10 Tablet and what is it used for?
Isordil 10 Tablet belongs to a group of medicines called organic nitrates. Isordil 10 Tablet is used to prevent and treat angina pectoris and as an adjunctive treatment in severe acute or chronic congestive cardiac failure.
Q. How does Isordil 10 Tablet work?
Isordil 10 Tablet works by widening the blood vessels in your heart to allow an increased amount of blood flow to areas which need it.
Q. Does Isordil 10 Tablet lower heart rate?
No, Isordil 10 Tablet does not lower heart rate. However, in some cases, one may experience reflex tachycardia (fast heart rate) while using nitrates such as Isordil 10 Tablet.
Q. Does Isordil 10 Tablet lower blood pressure?
Yes, Isordil 10 Tablet lowers blood pressure. This medicine widens the blood vessels and decreases the resistance in them, causing a fall in blood pressure. This fall in blood pressure may in turn decrease the heartbeat which can lead to angina. This medicine should be avoided in people who already have low blood pressure. Discuss with your doctor if you have any concerns.
