Ixempra 45mg (Injection)

Manufacturer: BMS India Pvt Ltd

Salt Composition : Ixabepilone(45mg)


It is important to inform your medical expert prior the course of Ixempra 45Mg Injection if you are taking any other prescription drugs, herbal or dietary supplements. The drug is generally not recommended for pregnant or lactating women as there may be potential fatal risks in fetus or infants. During the use of this drug, it is important to take care of yourself as it slightly increases the chances of infections and fever. It is also advised to avoid sun exposure as much as possible during the course of treatment. You must also abstain from smoking, tobacco and alcohol as they cause potentially fatal health risks.


In most cases the side effects to the Ixempra 45Mg Injection drug is tolerable and occurs for a temporary period only. But sometimes, there can be emergencies as well. Some adverse effects include peripheral neuropathy, weakness and malaise, muscular cramps or numbness, nausea, vomiting, dizziness, increased hair fall and decreased count of white blood cells. The drug is also known to cause loss of appetite, abdominal pain and sometimes persistent headaches.


Basic Information

Mechanism Of Action

Ixempra 45Mg Injection is used for treating metastatic and locally-advanced breast cancer. It is categorized as an antimicrotubule agent or epitholine B analog. The drug is used in chemotherapy where it works on microtubule structure and functions thereby inhibiting cell cycle that results in death of cells.


Pharmacokinets

Pharmacokinetics. Ixabepilone is more stable than natural epothilone B and has a half-life of 16–72 hours [150c,151R]. Like taxanes, ixabepilone is mostly metabolized in the liver, by CYP3A4/5.

Side Effects

Nausea

Vomiting

Fatigue

Fever

Muscle Pain

Musculoskeletal Bone

Muscle Or Joint Pain

Mucosal Inflammation

Decreased White Blood Cell Count

Anemia

Joint Pain

Hair Loss

Reduced Blood Platelets

Peripheral Sensory Neuropathy

Nail Disorder

Constipation

Loss Of Appetite

Diarrhoea

Contra Indications

with a known history of a severe (CTC grade 3/4) hypersensitivity reaction to agents containing Cremophor® EL or its derivatives such as polyoxyethylated castor oil.

who have a baseline neutrophil count <1500 cells/mm3 or a platelet count <100,000 cells/mm3.

Pregnancy Related Information

Ixempra 45mg injection is unsafe to use during pregnancy.

There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.

Product And Alcohol Interaction

Interaction with alcohol is unknown. Please consult your doctor.

Breast Feeding Related Information

Unknown. Human and animal studies are not available. Please consult your doctor.

Indications

(ixabepilone) is indicated in combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated.

Interactions

Some products that may interact with this drug include: drugs that cause a reaction with alcohol (such as disulfiram, metronidazole). Other medications can affect the removal of ixabepilone from your body, which may affect how ixabepilone works.


Storage Requirements

 Store below 30°C

Effects Of Missed Dosage

If you miss a dose of Ixabepilone, please consult your doctor.

Effects Of Overdose

please consult your doctor.

How To Use

Breast Cancer