Manufacturer: MSD Pharmaceuticals Pvt Ltd
Salt Composition : Sitagliptin(50mg), Metformin(500mg)
Janumet 50mg/500mg Tablet may be prescribed alone or along with other diabetes medications. It works best when used along with a healthy diet and regular exercise. The dose you are given will depend on your condition, blood sugar levels, and what other medicines you are taking. Taking it with meals helps to reduce the chances of developing an upset stomach.
Sitagliptin works by increasing insulin production by the body after a meal and decreasing sugar production by the body. Metformin works by restoring the natural response of the body to insulin and decreasing sugar production by the body.
Sitagliptin was well absorbed (approximately 80% excreted unchanged in the urine) with an apparent terminal half-life ranging from 8 to 14 hours. Renal clearance of sitagliptin averaged 388 mL/min and was largely uninfluenced by the dose administered.
Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Janumet
Hypoglycemia (low blood glucose level)
Nausea
Vomiting
Diarrhea
Decreased appetite
Abdominal bloating
Upper respiratory tract infection
Exfoliative dermatitis, history of angioedema, serious rash. ...
Type 1 diabetes mellitus. ...
Burns, fever, infection, surgery, trauma. ...
Diarrhea, gastroparesis, GI obstruction, ileus, vomiting. ...
Hypercortisolism, hyperglycemia, hyperthyroidism.
Janumet 50mg/500mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Janumet 50mg/500mg Tablet.
Janumet 50mg/500mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Janumet 50mg/500mg Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes such as kidney damage and blindness and may reduce your chances of having a heart attack or stroke.
Drug-Drug Interactions: Janumet 50 mg/500 mg Tablet 15's interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate) ...
Do not chew, crush or break it. Janumet 50mg/500mg Tablet
Store below 30°C
If you miss a dose of Janumet 50mg/500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
Take it with food to lower your chance of having an upset stomach.
Take it in addition to regular exercise and healthy diet to lower levels of blood sugar.
Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.
Monitor your blood sugar level regularly while you are taking this medicine.
Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Janumet 50mg/500mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Janumet 50mg/500mg Tablet is to be taken with food.
Q. What is Janumet 50mg/500mg Tablet?
Janumet 50mg/500mg Tablet is a combination of two medicines: Sitagliptin and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases the release of insulin from the pancreas. This combination is not indicated for the patients below 18 years of age.
Q. Can the use of Janumet 50mg/500mg Tablet lead to Vitamin B12 deficiency?
Yes, the use of Janumet 50mg/500mg Tablet can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems as a result of which the patient can feel tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.
Q. What are the possible side effects of Janumet 50mg/500mg Tablet?
The use of Janumet 50mg/500mg Tablet is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effect like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.
Q. Are there any specific conditions in which Janumet 50mg/500mg Tablet should not to be taken?
The use of Janumet 50mg/500mg Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis.
