Manufacturer: Panacea Biotec Ltd
Salt Composition : Lenalidomide(25mg)
Multiple myeloma is a type of cancer that affects a type of white blood cell (plasma cell) that collects in the bone marrow and divides uncontrollably, leading to kidney and bone damage. Myelodysplastic syndromes are a group of disorders that occur due to the abnormal functioning of blood cells.
Mantle cell lymphoma is a cancer of the lymph tissue where the B-cells or B lymphocytes (white blood cells) grow in an uncontrolled manner and build up in the lymph tissue, blood or bone marrow. Follicular lymphoma is slow-growing cancer that affects B lymphocytes that help fight infection.
Before taking LENOMUST 25MG CAPSULE, inform your doctor if you have ever had blood clots, hepatitis B infection, varicella-zoster, HIV, kidney problems or a heart attack. LENOMUST 25MG CAPSULE is not recommended for use among pregnant or breastfeeding women. Consult your doctor before taking it.
The most common side effects of taking LENOMUST 25MG CAPSULE are rashes, itching, muscle cramps, muscle weakness, muscle pain, muscle aches, bone pain, joint pain, back pain, pain in the extremities, weakness, tiredness, constipation, diarrhoea, nausea, vomiting, stomach pain and heartburn. Consult your doctor if any of the symptoms worsen.
LENOMUST 25MG CAPSULE works by enhancing the immune system that indirectly attacks the cancer cells. It stops the growth of new blood vessels within the tumour. It also limits the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells.
Approximately 82 % of an oral dose is excreted as lenalidomide in urine within 24 h. Lenalidomide has a short half-life (3–4 h) and does not accumulate in plasma upon repeated dosing. Its pharmacokinetics are consistent across patient populations, regardless of the type of hematologic malignancy.
COMMON
Anemia (symptoms include tiredness and weakness), hemolytic anemia (destruction of red blood cells)
Rashes, itching
Muscle cramps, muscle pain, muscle aches, muscle weakness, bone pain, joint pain, back pain, pain in the extremities
Generalized swelling (swelling of arms and legs)
Weakness, tiredness
Fever and flu-like symptoms (fever, muscle ache, headache, earache, cough and chills)
Numbness, pains in hands or feet, tremors, tingling or burning sensation to the skin, dizziness
Decreased appetite, change in the way things taste
Increase in pain, tumor size or redness around the tumor
Weight loss
Constipation, diarrhea, nausea, vomiting, stomach pain, heartburn
Low levels of potassium or calcium and/or sodium in the blood
Less thyroid functioning
Thrombosis and pulmonary embolism (symptoms include leg pain, chest pain, shortness of breath and blood clots in the lungs)
Infections of all types (including infections of the sinuses that surround the nose, infections of the lung and the upper respiratory tract)
Shortness of breath
Blurred vision
Clouding of your eye (cataract)
Kidney problems
Abnormal liver test results
Vasculitis (changes to a protein in the blood that can cause swelling of the arteries)
Diabetes
Headache
Nosebleed
Dry skin
Depression, mood change, difficulty sleeping
Cough
Decreased blood pressure
A vague feeling of bodily discomfort, feeling bad
Sore inflamed mouth, dry mouth
Dehydration
Certain types of skin tumors
Bleeding of the bowel, stomach or gums
Increased blood pressure, fast, slow or irregular heartbeat
Normal and abnormal breakdown of red blood cells
Increase in a type of protein that indicates inflammation in the body
Darkening of the skin, discoloration of the skin resulting from bleeding underneath, typically caused by bruising, swelling of skin filled with blood, bruise
Increased blood uric acid
Skin eruptions, redness of the skin, cracking, flaking or peeling skin, hives
Increased sweating, night sweats
Difficulty swallowing, sore throat, difficulty with voice quality or voice changes
Runny nose
Less urine than usual or the inability to control when to urinate
Blood in the urine
Shortness of breath particularly when lying down (which may be a symptom of heart failure)
Difficulty getting an erection
Stroke, vertigo, fainting, temporary loss of consciousness
Chest pain spreading to the arms, neck, jaw, back or stomach, feeling sweaty and breathless, feeling sick or vomiting, which may be symptoms of a heart attack (myocardial infarction)
Muscle weakness, lack of energy
Neck pain
Joint swelling
Bile flow from the liver slowed or blocked
Low levels of magnesium or phosphate in the blood
Difficulty speaking
Liver injury
Impaired balance, difficulty moving
Deafness, ringing in the ears (tinnitus)
Nerve pain, unpleasant abnormal sensation, especially to touch
Excess of iron in the body
Thirst
Confusion
Toothache
Fall which may result in injury
UNCOMMON
Bleeding within the skull
Circulatory problems
Loss of vision
Loss of sex drive (libido)
Kidney disorder (Fanconi syndrome) (symptoms include passing large amounts of urine with bone pain and weakness)
Jaundice (yellow pigmentation to the skin, mucus membrane or eyes), pale-colored stools, dark-colored urine, skin itch, rash, pain or swelling of the stomach (symptoms of injury to the liver) (hepatic failure)
Colitis or caecitis (symptom includes stomach pain, bloating or diarrhea)
Renal tubular necrosis (damage to the cells of the kidney)
Changes to the color of skin, sensitivity to sunlight
Tumor lysis syndrome (symptoms include changes to blood chemistry, high potassium, phosphorus, uric acid and low calcium consequently leading to changes in kidney function, heartbeat, seizures and sometimes death)
Pulmonary hypertension (increase in blood pressure within blood vessels that supply the lungs)
RARE
Stop taking LENOMUST 25MG CAPSULE and contact your doctor immediately if you experience any of the following side effects;
Angioedema and anaphylactic reaction (symptoms include hives, rashes, swelling of eyes, mouth or face, difficulty breathing or itching)
Stevens-Johnson syndrome and/or toxic epidermal necrolysis (a serious allergic reaction that may begin as a rash in one area but spread with extensive loss of skin over the whole body)
Drug reaction with eosinophilia and systemic symptoms which is also known as DRESS or drug hypersensitivity syndrome (symptom includes widespread rash, high body temperature, liver enzyme elevations, blood abnormalities (eosinophilia), enlarged lymph nodes and other body organs involvement)
contraindicated in patients who have demonstrated hypersensitivity (e.g., angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis) to lenalidomide
LENOMUST 25MG CAPSULE is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor before taking it.
Avoid consumption of alcohol while taking LENOMUST 25MG CAPSULE.
LENOMUST 25MG CAPSULE is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking it.
Lenalidomide is indicated for the treatment of adult patients with multiple myeloma (MM) in combination with dexamethasone. It is also indicated as maintenance therapy in multiple myeloma following autologous hematopoietic stem cell transplantation (auto-HSCT).
Drug-Drug Interactions: LENALIDOMIDE may interact with digitalis glycosides (digoxin), blood thinner (warfarin), and hormone (erythropoietin).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have anaemia, blood clots, infections, heart, kidney, or liver problems.
Drug-Drug Interactions Checker List:
DIGOXIN
WARFARIN
ERYTHROPOIETIN
Keep LENOMUST 25MG CAPSULE out of reach from children
Store at room temperature
If you or anyone else accidentally take too much of LENOMUST 25MG CAPSULE, consult your doctor immediately or visit the nearby hospital.
Take LENOMUST 25MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
How does LENOMUST 25MG CAPSULE work?
LENOMUST 25MG CAPSULE works by enhancing the immune system, which indirectly attacks cancer cells. It stops the growth of new blood vessels within the tumour. It also limits the production of chemical messengers (cytokines and growth factors), which are responsible for the growth of cancer cells.
Is it safe to use LENOMUST 25MG CAPSULE on the elderly?
In elderly patients (75 years and older), LENOMUST 25MG CAPSULE should be used with caution. Consult your doctor before taking LENOMUST 25MG CAPSULE.
For what is LENOMUST 25MG CAPSULE used?
LENOMUST 25MG CAPSULE is an immunomodulatory agent used in the treatment of multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma and follicular lymphoma.
Are there any dietary restrictions when taking LENOMUST 25MG CAPSULE?
LENOMUST 25MG CAPSULE can be taken with or without food; there is no food restriction as such. Consult your doctor before taking LENOMUST 25MG CAPSULE.
