Leuprolide has a terminal elimination half-life of approximately three hours. Leuprolide administered as a 1 mg intravenous bolus in healthy males has a mean systemic clearance between 7.6 and 8.3 L/h. Leuprolide is considered extremely safe, with low dose-related toxicity and comparatively mild adverse effects.
Serious
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Injection site reactions such as abscess
Pain throughout body
Headache
Acne or red, itchy, rash, and white scales (seborrhea)
Serious skin rash (erythema multiforme)
Mood changes
Swelling of vagina (vaginitis), vaginal bleeding, and vaginal discharge
Contraindications to leuprolide therapy include hypersensitivity to leuprolide or any other gonadotropin-releasing hormone agonists. [13] This medication should not be used in women who are or may become pregnant. A negative pregnancy test is necessary before starting the medication.
Tell your doctor before using this medicine if you are pregnant or planning to become pregnant or breast feeding
Tell your doctor before using this medicine if you are pregnant or planning to become pregnant or breast feeding
Leuprolide is a medication used in the management and treatment of prostate cancer, endometriosis, uterine fibroids, precocious puberty, and other sex hormone-related conditions. It is in the GnRH agonist class of medications.
Drug-Drug Interaction: LEUPROLIDE may interact with heart rhythm problems treating drugs (quinidine, procainamide, disopyramide, amiodarone, sotalol), steroids (dexamethasone, methylprednisolone) and prednisone antibiotics (moxifloxacin), opioid pain killers (methadone) and antipsychotics (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline).
Drug-Food Interaction: No interactions found/established.
Drug-Disease Interaction: LEUPROLIDE should be used with caution in cases of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels.
Drug-Drug Interactions Checker List:
QUINIDINE
PROCAINAMIDE
DISOPYRAMIDE
AMIODARONE
DEXAMETHASONE
METHYLPREDNISOLONE
PREDNISOLONE
MOXIFLOXACIN
METHADONE
CITALOPRAM
ESCITALOPRAM
FLUOXETINE
FLUVOXAMINE
PAROXETINE
SERTRALINE
Do not freeze LUCRIN DEPOT
Allow the product to reach room temperature before mixing
Once mixed, the product must be administered within 30 minutes or it should be discarded
Store at temperature (2-8°C)
Once outside the refrigerator this product may be stored in its original packaging at room temperature (15–30°C) for up to eight weeks prior to mixing and administration
Keep this medicine out of the reach of children
Do not use this medicine after the expiry date
Are allergic to GnRH, GnRH agonist medicines, or any ingredients in LUCRIN DEPOT
Have a history of mental (psychiatric) problems
Have a history of seizures(fits)
Have a history of brain or brain vessel problems or tumors
Have heart problem
Have diabetes mellitus
This medicine will be given by your doctor or nurse
It is given as subcutaneous injection (under the skin)
Injection site is usually on the abdomen, upper buttocks, or another location with adequate amounts of soft tissue
