Manufacturer: Abbott
Salt Composition : Leuprolide(3.75mg)
Endometriosis is a chronic disease in which a tissue like the uterus lining grows outside the uterus, resulting in pain and/or infertility. It is characterized by symptoms such as pain during periods, pelvic pain, pain associated with sexual intercourse, painful urination, fatigue, depression, bloating and nausea.
Do not receive LUCRIN DEPOT 3.75MG INJECTION if you are allergic to Leuprolide, GnRH, or GnRH agonist analogs.
Before receiving this medicine, inform your doctor if you have liver impairment, kidney impairment, or undiagnosed abnormal uterine bleeding.
Inform your doctor if you are chronic alcohol or tobacco user or have strong family history of osteoporosis or chronic use of medicines.
LUCRIN DEPOT 3.75MG INJECTION is not recommended for use in pregnant women. It should be used with caution in breastfeeding women only if considered necessary. It is not recommended for use in premenarcheal children and postmenopausal women. Consult your doctor before receiving.
The common side effects associated with the use of LUCRIN DEPOT 3.75MG INJECTION are hot flashes/sweating, general pain, headache, gastrointestinal disorders, swelling due to water retention, nausea, vomiting, reduced libido, and dizziness. Consult your doctor if any of these side effects worsens.
LUCRIN DEPOT 3.75MG INJECTION contains Leuprolide which helps in managing endometriosis and fibroids. It works by blocking the secretion of gonadotropin releasing hormone (GnRH) following an initial stimulation, resulting in suppression of ovarian and testicular steroidogenesis (process of synthesis of steroid hormones), thereby relieving the symptoms associated with increased levels of sex hormones.
Leuprolide has a terminal elimination half-life of approximately three hours. Leuprolide administered as a 1 mg intravenous bolus in healthy males has a mean systemic clearance between 7.6 and 8.3 L/h. Leuprolide is considered extremely safe, with low dose-related toxicity and comparatively mild adverse effects.
COMMON
Hot flashes/sweating
Headache
Vaginitis (inflammation in the vagina)
Depression/emotional lability
General pain
Weight gain or loss
Nausea
Vomiting
Reduced libido
Dizziness
Acne
Skin reactions
Joint disorder
Oedema (swelling due to water retention)
Paraesthesia (sensation of burning and pricking)
Gastrointestinal disturbances
Neuromuscular disorders
Breast changes or breast pain
Nervousness
Extreme weakness
Urinary tract infection
Stop receiving LUCRIN DEPOT 3.75MG INJECTION and contact your doctor if you experience any of the following side effects:
Signs of pituitary apoplexy such as sudden headache, visual changes, vomiting, weakened eye muscles, altered mental status, sudden loss of heart function
Urinary tract infection
Renal calculus (kidney stones)
Depression
Contraindications to leuprolide therapy include hypersensitivity to leuprolide or any other gonadotropin-releasing hormone agonists. [13] This medication should not be used in women who are or may become pregnant. A negative pregnancy test is necessary before starting the medication.
LUCRIN DEPOT 3.75MG INJECTION is not recommended for use during pregnancy as it may increase the risk of pregnancy complications such as early pregnancy loss and foetal harm. Consult your doctor before receiving.
LUCRIN DEPOT 3.75MG INJECTION should be used with caution breastfeeding women only if considered necessary because it is not known whether it can pass through milk. Consult your doctor before receiving.
Leuprolide is a medication used in the management and treatment of prostate cancer, endometriosis, uterine fibroids, precocious puberty, and other sex hormone-related conditions. It is in the GnRH agonist class of medications.
Drug-Drug Interaction: LEUPROLIDE may interact with heart rhythm problems treating drugs (quinidine, procainamide, disopyramide, amiodarone, sotalol), steroids (dexamethasone, methylprednisolone) and prednisone antibiotics (moxifloxacin), opioid pain killers (methadone) and antipsychotics (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline).
Drug-Food Interaction: No interactions found/established.
Drug-Disease Interaction: LEUPROLIDE should be used with caution in cases of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels.
Drug-Drug Interactions Checker List:
QUINIDINE
PROCAINAMIDE
DISOPYRAMIDE
AMIODARONE
DEXAMETHASONE
METHYLPREDNISOLONE
PREDNISOLONE
MOXIFLOXACIN
METHADONE
CITALOPRAM
ESCITALOPRAM
FLUOXETINE
FLUVOXAMINE
PAROXETINE
SERTRALINE
Keep LUCRIN DEPOT 3.75MG INJECTION out of reach of children
Store between 2-8°C
LUCRIN DEPOT 3.75MG INJECTION will be administered to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital.
LUCRIN DEPOT 3.75MG INJECTION will be administered to you only by a doctor or a nurse intramuscularly (into the muscle). Your doctor will adminster the correct dose and duration for you depending upon your age, body weight and disease condition.
Q: What is LUCRIN DEPOT 3.75MG INJECTION used for?
A: LUCRIN DEPOT 3.75MG INJECTION is used to manage endometriosis, relieving pain, and reducing endometriotic lesions. It is also used for preoperative hematologic improvement in women having fibroids (abnormal growth in uterus) induced anaemia for whom hormonal suppression is considered necessary for three months. Consult your doctor before receiving.
Q: What side effects are seen with LUCRIN DEPOT 3.75MG INJECTION?
A: The common side effects associated with the use of LUCRIN DEPOT 3.75MG INJECTION are hot flashes/sweating, general pain, headache, gastrointestinal disorders, swelling due to water retention, nausea, vomiting, reduced libido, and dizziness. Consult your doctor if any of these side effects worsens.
Q: Who should avoid receiving LUCRIN DEPOT 3.75MG INJECTION?
A: Do not receive LUCRIN DEPOT 3.75MG INJECTION if you are allergic to Leuprolide, GnRH, or GnRH agonist analogs. It is not recommended for use in pregnant women, premenarcheal children and postmenopausal women. Consult your doctor before receiving.
Q: Is LUCRIN DEPOT 3.75MG INJECTION safe to use in children?
A: LUCRIN DEPOT 3.75MG INJECTION is not recommended for use in premenarcheal children and adolescents (below 18 years). However, the efficacy of this medicine is expected to be the same for post pubertal adolescents (below 18 years) as for women (aged 18 years or older). Consult your doctor before receiving.
Q: Is LUCRIN DEPOT 3.75MG INJECTION safe to use in elderly patients?
A: LUCRIN DEPOT 3.75MG INJECTION is not recommended for use in postmenopausal women. Menopause is natural cessation of menstrual cycles that marks the end of reproductive life in females. Consult your doctor before receiving this medicine.
Q: Is LUCRIN DEPOT 3.75MG INJECTION safe to use in pregnant women?
A: LUCRIN DEPOT 3.75MG INJECTION is not recommended for use during pregnancy as it may increase the risk of pregnancy complications such as early pregnancy loss and foetal harm. Consult your doctor before receiving.
Q: Is LUCRIN DEPOT 3.75MG INJECTION safe to use in breastfeeding women?
A: LUCRIN DEPOT 3.75MG INJECTION should be used with caution breastfeeding women only if considered necessary because it is not known whether it can pass through milk. Consult your doctor before receiving.
