Manufacturer: Lupin Ltd
Salt Composition : Bosentan(62.5mg)
Lupibose 62.5 Tablet should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.
The most common side effects of this medicine include headache, swelling of the legs and ankles, and diarrhea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function.
Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Women are suggested to use reliable contraceptive pills to avoid pregnancy and should continue even after one month of stopping the treatment. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.
Lupibose 62.5 Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Lupibose 62.5 Tablet helps relax these blood vessels and increases the supply of blood to the lungs.
The mechanism of action of bosentan is competitive inhibition of endothelin-1 receptors. Endothelin-1 is a potent vasoconstrictor, which also mediates cell proliferation, fibrosis and inflammation.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lupibose
Headache
Ankle swelling
Edema (swelling)
Diarrhea
Anemia (low number of red blood cells)
Respiratory tract infection
If you are suffering from any of the following diseases, you should not take Bosentan unless your doctor advises you to do so -
Edema
Liver Disease
Anemia
Lupibose 62.5 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Lupibose 62.5 Tablet may cause excessive drowsiness with alcohol.
Lupibose 62.5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
Bosentan is used to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs) in adults and children 3 years of age and older. Bosentan may improve the ability to exercise and slow the worsening of symptoms in patients with PAH.
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Do not chew, crush or break it. Lupibose 62.5 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Lupibose 62.5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Your doctor has prescribed Lupibose 62.5 Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Lupibose 62.5 Tablet affects you.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Lupibose 62.5 Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lupibose 62.5 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. How is Lupibose 62.5 Tablet administered?
Lupibose 62.5 Tablet is given as a tablet form and can be taken with or without food. The tablets are to be taken twice daily in the morning and evening. The exact dosage and frequency of dose will be decided by the doctor on the basis of age and weight of the patient.
Q. Are there chances of anemia with Lupibose 62.5 Tablet?
Yes, there are chances that Lupibose 62.5 Tablet may cause anemia. It can cause a dose-related decrease in hemoglobin in the blood which could lead to anemia. Regular hemoglobin check is advised while taking this medicine and consult your prescribing doctor for his advice. In some cases, blood transfusion is done to treat anemia.
Q. Can I take Lupibose 62.5 Tablet if I have liver problems?
It has been found that in some cases Lupibose 62.5 Tablet can cause liver damage in patients who are prone to have liver disease. This medicine can also lead to increased liver enzymes. Hence, it should be used with caution in prone patients or in patients with history of liver disease. Before starting the medication inform your doctor if you have had a history of liver disease.
Q. Is Lupibose 62.5 Tablet safe in pregnancy?
No, Lupibose 62.5 Tablet is not safe during pregnancy. There is evidence to show that it can cause major birth defects in the newborn baby and can harm the baby in womb. It is not advised to take Lupibose 62.5 Tablet if you are planning to become pregnant. You should use reliable contraception methods while you take Lupibose 62.5 Tablet. Consult your doctor before starting this medication or planning pregnancy.
