Manufacturer: Lupin Ltd
Salt Composition : Ibuprofen(400mg), Paracetamol(325mg)
Lupiflam 400 mg/325 mg Tablet is best taken with food to reduce side effects. The dose and how often you need it will be decided by your doctor. You should take it regularly as advised by your doctor. Medicines used to treat pain are usually best taken at the first sign of pain. It is meant for short-term use only. Consult your doctor if the symptoms persist or worsen or if the medicine is required for use beyond 3 days.
Side effects are rare if this medicine is used correctly but it may cause heartburn, indigestion, nausea, and stomach pain. Consult your doctor if any of these bother you or do not go away.
This medicine is widely prescribed and considered safe but may not be suitable for everybody. Before taking it, let your doctor know if you drink a lot of alcohol, are using blood-thinning medicines, or have asthma or any liver or kidney problems. It may affect the dose or suitability of this medicine. Pregnant or breastfeeding women should also consult their doctor before using it. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. It is best to avoid drinking alcohol while using this medicine.
Lupiflam 400 mg/325 mg Tablet is a combination of two medicines: Ibuprofen and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).
Ibuprofen is rapidly and completely absorbed following oral administration (tmax, ~ 1–2 h depending on the specific oral formulation), and unbound concentrations show linear pharmacokinetics at commonly used doses [1,5]. It is extensively (>98%) bound to plasma proteins at therapeutic concentrations.It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lupiflam
Heartburn
Indigestion
Nausea
Stomach pain
If you are suffering from any of the following diseases, you should not take Ibuprofen + Paracetamol Tablet unless your doctor advises you to do so -
Nausea and Vomiting
Allergy
Gastrointestinal Bleeding
Kidney Disease
Cardiac Arrest
Liver Disease
Lupiflam 400 mg/325 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Lupiflam 400 mg/325 mg Tablet.
Lupiflam 400 mg/325 mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Ibuprofen+Paracetamol is used for pain relief and fever. It relieves pain in conditions like headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis or painful menses.
IBUPROFEN+PARACETAMOL is shown to interact with various drugs. Some of them include lithium, blood thinner or anticoagulant (warfarin, ticlopidine), anti-arthritis pills (methotrexate), blood pressure or heart medicine, nausea/vomiting medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophylline, ephedrine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine).
Do not chew, crush or break it. Lupiflam 400 mg/325 mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Lupiflam 400 mg/325 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed this combination medicine to relieve pain, inflammation, and fever.
Take it with food to avoid getting an upset stomach.
Take it as per the dose and duration prescribed by your doctor. Long-term use may lead to stomach bleeding and kidney problems.
Avoid consuming alcohol when taking Lupiflam 400 mg/325 mg Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
Do not take it with any other medicine containing paracetamol (drugs for pain/fever or cough and cold) without asking your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lupiflam 400 mg/325 mg Tablet is to be taken with food.
Q. Is it safe to use Lupiflam 400 mg/325 mg Tablet?
Lupiflam 400 mg/325 mg Tablet is safe for most patients. However, in some patients, it may cause some unwanted side effects like nausea, vomiting, stomach pain, heartburn and diarrhea. Inform your doctor if you experience any persistent problem due to this medication.
Q. Can I stop taking Lupiflam 400 mg/325 mg Tablet when my pain is relieved?
Lupiflam 400 mg/325 mg Tablet should be continued as advised by your doctor, if you are using the medicine for a condition associated with long-term pain. It can be discontinued if you are using it for short-term pain relief.
Q. Can the use of Lupiflam 400 mg/325 mg Tablet cause nausea and vomiting?
Yes, the use of Lupiflam 400 mg/325 mg Tablet may cause nausea and vomiting. Taking it with milk, food or antacids can prevent nausea. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine or a low frequency of urination. Do not take any other medicines without speaking to your doctor.
Q. Can the use of Lupiflam 400 mg/325 mg Tablet cause dizziness?
Yes, the use of Lupiflam 400 mg/325 mg Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, do not drive or use any machines. It is better to rest for sometime and resume once you feel better.
Q. Are there any specific contraindications associated with the use of Lupiflam 400 mg/325 mg Tablet?
The use of Lupiflam 400 mg/325 mg Tablet is considered to be harmful for patients with known allergy to any of the components of this medicine. It should be avoided in patients with known allergy to other painkillers (NSAIDs). The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active or recurrent stomach ulcer/bleeding. It should also be avoided in patients with history of heart failure, high blood pressure, and liver or kidney disease.
Q. Is Lupiflam 400 mg/325 mg Tablet helpful in relieving stomach pain?
No, Lupiflam 400 mg/325 mg Tablet should not be taken for stomach pain without consulting a physician. This drug can increase stomach acid secretion which may aggravate an unknown underlying condition.
Q. Can the use of Lupiflam 400 mg/325 mg Tablet cause damage to kidneys?
Yes, the long-term use of Lupiflam 400 mg/325 mg Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protect the kidneys from damage. Use of painkillers lowers the levels of prostaglandins in the body, leading to kidney damage because of long-term use. Therefore, the use of painkillers is not recommended in patients with underlying kidney disease.
Q. Is it safe to take a higher than the recommended dose of Lupiflam 400 mg/325 mg Tablet ?
No, taking a higher than the recommended dose of Lupiflam 400 mg/325 mg Tablet can increase the risks of side effects like nausea, vomiting, heartburn, indigestion and diarrhea. In fact, using this medicine for a long-term can also damage your kidneys on long-term use. If you are experiencing increased severity of pain or if the pain is not relieved by the recommended doses of this medicine, please consult your doctor for re-evaluation.
