Manufacturer: Lupin Ltd
Salt Composition : Insulin Isophane/NPH(0.5), Human Insulin/Soluble Insulin(0.5)
Cartridge of 3ml Injection
(Inclusive of all taxes)
Lupisulin M 50 Injection 100IU/ml is normally prescribed along with other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. It should be taken 15 minutes before a meal or within 20 minutes after starting a meal. Don’t stop taking it unless your doctor tells you to.
It is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Check your blood sugar levels regularly, keep track of your results and share them with your doctor. This is very important to work out the correct dose of the medicine for you.
The most common side effect of this medicine is low blood sugar levels (hypoglycemia). To prevent this, it's important to always inject the correct dose of medicine only, have regular meals, and monitor your blood sugar levels regularly. Drinking excessive alcohol can also lead to a fall in your blood sugar levels. Other side effects include reactions at the injection site like redness or swelling. Some people gain weight while taking insulin. You may also notice a rash, edema (swelling), or itching while taking this medicine.
Do not use this medicine when you have low blood glucose levels (hypoglycemia). Tell your doctor if you’ve ever had kidney, liver or heart problems before starting treatment. Pregnant or breastfeeding women should also consult their doctor as the dose may need to be changed.
Lupisulin M 50 Injection 100IU/ml is a combination of two insulin preparations: Insulin Isophane / NPH and Human Insulin / Soluble Insulin. Insulin Isophane / NPH has a prolonged duration of action, while human insulin / soluble insulin has a fast onset of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells and suppressing the production of sugar in the liver.
Isophane insulin (NPH) is administered via the subcutaneous route by intermittent injections only. After subcutaneous administration, the onset of glucose lowering activity begins approximately 1—4 hours after injection with maximal activity occurring between 4 and 14 hours (mean 5.5 hours).The pharmacokinetics of insulin comprise the absorption process, the distribution including binding to circulating insulin antibodies, if present, and to insulin receptors, and its ultimate degradation and excretion. The distribution and metabolism of absorbed insulin follow that of endogenous insulin.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lupisulin M
Hypoglycemia (low blood glucose level)
Injection site reactions (pain, swelling, redness)
Weight gain
INSULIN HUMAN+INSULIN ISOPHANE should not be given to patients with kidney disease, liver disease, low potassium level (hypokalaemia), and low blood sugar/glucose level (hypoglycemia).
Lupisulin M 50 Injection 100IU/ml is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is unsafe to consume alcohol with Lupisulin M 50 Injection 100IU/ml.
Lupisulin M 50 Injection 100IU/ml is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Use with caution
Below 9years: Contraindicated
Insulin Isophane/NPH + Human Insulin/Soluble Insulin is a combination of two insulin preparations: Insulin Isophane / NPH and Human Insulin / Soluble Insulin. Insulin Isophane / NPH has a prolonged duration of action, while human insulin / soluble insulin has a fast onset of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells and suppressing the production of sugar in the liver.
This medicine may have an interaction with anti-depressants (phenelzine, iproniazid, isocarboxazid, nialamide, imipramine, desipramine, tranylcypromine, moclobemide), anti-Parkinson’s drug (selegiline), antibiotic (linezolid), (lithium, tryptophan), migraines drug (sumatriptan), pain killer (tramadol), anti-ulcer (cimetidine, lansoprazole, omeprazole), anti-fungal (fluconazole), anti-stroke pills (ticlopidine), blood-thinners (warfarin, dipyridamole, and phenprocoumon), antimalarial (mefloquine), heart-related drug (flecainide, propafenone), and medicines that decrease blood levels of potassium or magnesium, as these increase the risk of life-threatening heart rhythm disorder. Besides this, the use of oral antidiabetic pills like pramlintide acetate and antibiotics (pentamidine) may cause hypoglycemia (low blood sugar level).
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you have missed a dose of Lupisulin M 50 Injection 100IU/ml, your blood sugar level may become too high (hyperglycemia). Check your blood sugar and then take the next dose accordingly.
Consult a doctor before taking any medicines.
Take it 15 minutes before a meal or within 20 minutes after starting a meal.
Injection below the skin of the abdomen results in faster absorption than other injection sites such as skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
Injection sites must be rotated to prevent hard lumps from developing at one site.
Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
Do not share your insulin device with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
Opened vials / cartridges stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Can I drink alcohol while taking Lupisulin M 50 Injection 100IU/ml?
No, it is not safe to drink alcohol while using Lupisulin M 50 Injection 100IU/ml. Drinking alcohol while using this medicine may lower your blood sugar levels and cause unexpected hypoglycemia.
Q. What are the instructions for storage and disposal of Lupisulin M 50 Injection 100IU/ml?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Which is the best area to inject Lupisulin M 50 Injection 100IU/ml?
Lupisulin M 50 Injection 100IU/ml is to be injected under the skin (subcutaneously). The best areas to give Lupisulin M 50 Injection 100IU/ml are your stomach, upper thigh, upper arm or buttocks.
Q. What are the symptoms of high blood sugar?
Symptoms of high blood sugar include frequent urination, increased thirst, fatigue, nausea, vomiting, shortness of breath, stomach pain, fruity breath odor, dry mouth and a fast heartbeat.
