Manufacturer: Lupin Ltd
Salt Composition : Human insulin(100IU)
Cartridge of 3ml Solution For Injection
(Inclusive of all taxes)
Lupisulin R 100IU/ml Cartridge is normally prescribed along with a long-acting type of insulin or other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. It should be taken 20-30 minutes before a meal. Do not stop taking it unless your doctor tells you to. It is only a part of the treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor.
Check your blood sugar levels regularly, keep track of your results and share them with your doctor. This is very important to work out the correct dose of the medicine for you.
The most common side effect of this medicine is low blood sugar levels (hypoglycemia). It may be seen if you do not eat right after a dose of this fast-acting insulin. To prevent this, it is important to always inject only the correct dose of medicine, have regular meals, and monitor your blood sugar levels regularly. Drinking excessive alcohol can also lead to a fall in your blood sugar levels. Other side effects include reactions at the injection site like redness or swelling. Some people gain weight while taking insulin.
Do not use this medicine when you have low blood sugar levels (hypoglycemia). Tell your doctor if you have ever had kidney, liver, or heart problems before starting treatment. Pregnant or breastfeeding women should also consult their doctor as the dose may need to be changed.
Lupisulin R 100IU/ml Cartridge is a short-acting insulin, which starts working within 30 minutes after injection. It works similar to the insulin produced by the body. Insulin facilitates reuptake of sugar in muscle and fat cells and also suppresses the production of sugar in the liver.
The pharmacokinetics of insulin comprise the absorption process, the distribution including binding to circulating insulin antibodies, if present, and to insulin receptors, and its ultimate degradation and excretion. The distribution and metabolism of absorbed insulin follow that of endogenous insulin.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lupisulin R
Hypoglycemia (low blood glucose level)
Weight gain
Edema (swelling)
Injection site reactions (pain, swelling, redness)
If you are suffering from any of the following diseases, you should not take Insulin Injection unless your doctor advises you to do so -
Liver Disease
Hypoglycemia (Low Blood Sugar)
Kidney Disease
Potassium Deficiency
Peripheral Neuropathy
Lupisulin R 100IU/ml Cartridge is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
It is unsafe to consume alcohol with Lupisulin R 100IU/ml Cartridge.
Lupisulin R 100IU/ml Cartridge is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Use with caution
Below 9years: Contraindicated
Human insulin is used to control blood sugar in people who have type 1 diabetes (condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood) or in people who have type 2 diabetes (condition in which the blood sugar is too high because the body does not produce or use insulin normally) that cannot be controlled with oral medications alone.
INSULIN HUMAN may have an interaction with drugs, including antidiabetic or blood sugar enhancing pills (glucagon, glipizide, metformin, sitagliptin, canagliflozin), blood pressure-lowering medicines (metoprolol, hydrochlorothiazide), bleeding disorder drugs (octreotide), antipsychotic (propoxyphene, phenothiazines), female sex hormones (progestogen, oestrogen), thyroid hormones (levothyroxine), anti-asthmatics (albuterol, epinephrine, terbutaline), an antidepressant (fluoxetine, lithium), lipid-lowering pills (reserpine, niacin, clonidine, fenofibrate, guanethidine), pain killers (aspirin). If you are taking any of the above, speak with your doctor.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you forget to take Lupisulin R 100IU/ml Cartridge, your blood sugar may get too high (hyperglycemia). Take it as soon as you remember. If it's time for your next dose then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.
Consult a doctor before taking any medicines.
Take it 20 to 30 minutes before a meal.
Hypoglycemia (low blood sugar level) is a common side-effect. Learn how to identify and manage its symptoms (sweating, rapid heartbeat, weakness, blurry vision, headache) and teach your family as well.
Injection below the skin of the abdomen results in faster absorption than other injection sites.
Injection sites must be rotated to prevent hard lumps from developing at one site.
Opened vials/cartridges are good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
Your doctor or nurse will guide you how to use this medicine.
Q. Will I need Lupisulin R 100IU/ml Cartridge for the rest of my life?
If you are a type 1 diabetes patient, then yes, you have to take Lupisulin R 100IU/ml Cartridge for the rest of your life because your body is unable to produce sufficient insulin. Therefore, you would need Lupisulin R 100IU/ml Cartridge as an external source of insulin. However, if you are a type 2 diabetes patient, sometimes your doctor may ask you to stop Lupisulin R 100IU/ml Cartridge if you are able to manage your diabetes with proper exercise, diet and oral medicines.
Q. Can Lupisulin R 100IU/ml Cartridge be used with other diabetes medicine?
Yes, Lupisulin R 100IU/ml Cartridge can be used alone or in combination with other diabetes medicines like long-acting insulin or oral diabetes medicines, along with proper diet and exercise. Follow your doctor’s advice and treatment plan to get the maximum benefit.
Q. How should Lupisulin R 100IU/ml Cartridge be used?
Lupisulin R 100IU/ml Cartridge is injected under the skin (subcutaneously). Your doctor will show you the area of your skin where you should inject it. Try not to inject on the same spot every time. Rotate between the typical injection sites, such as abdomen, buttocks, upper legs or upper arms. Never inject Humalog into a muscle or vein. Move to a new injection site every week or two. Inject in the same area of the body, making sure to move around within that area with each injection, for one or two weeks. You can then move to another area of your body and repeat the process. Use the same area for at least a week to avoid extreme blood sugar variations.
Q. Is Lupisulin R 100IU/ml Cartridge safe to use in pregnancy?
Yes. Lupisulin R 100IU/ml Cartridge is safe to use in pregnancy if prescribed by a doctor. However, please inform your doctor if you are pregnant, planning pregnancy or breastfeeding before using Lupisulin R 100IU/ml Cartridge. You may require dose modifications and your doctor will advise you to monitor your blood sugar levels regularly. You must follow the instructions of your doctor to get maximum benefits.
Q. Is Lupisulin R 100IU/ml Cartridge safe to use in type 2 diabetes?
Yes, insulin is safe to use in type 2 diabetes if used according to your doctor's advice. Keep monitoring your blood sugar levels regularly as advised. Your dosage may need to be adjusted as per your needs. Follow the lifestyle changes as advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.
Q. What are the side effects of Lupisulin R 100IU/ml Cartridge? How to prevent them?
The side effects of Lupisulin R 100IU/ml Cartridge are injection site reactions such as redness, itching, pain and swelling. However, these are temporary and usually resolve on their own. Rarely, it can also cause lipodystrophy, which means abnormal changes in the fat tissues due to repeated insulin injections in the same area of the skin. It includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption. Rotate insulin injection or infusion sites within the same region to reduce the risk of lipodystrophy.
Q. Can Lupisulin R 100IU/ml Cartridge cause hypoglycemia? How do I prevent it?
Yes, the most common side effect of Lupisulin R 100IU/ml Cartridge is hypoglycemia. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, do not skip meals and be consistent in the timing and amount of your meals. Take some snacks as per your requirement if you over exercise. Regular monitoring of the blood sugar level is important. Always carry some sugary candies, glucose/glucon-D or fruit juice with you. Take all the medicines prescribed by the doctor on time and consult your doctor if you notice any fluctuations in your blood sugar levels.
Q. Is Lupisulin R 100IU/ml Cartridge given as an injection into a vein (intravenous)?
Yes, sometimes, in specific situations like diabetic ketoacidosis, severe hyperglycemia etc, Lupisulin R 100IU/ml Cartridge may be given as an injection into a vein (intravenous). However, in such cases, it is only given by a doctor, under continuous monitoring of blood sugar levels in a hospital setting.
Q. When does the dosage of Lupisulin R 100IU/ml Cartridge need to be changed?
You should consult your doctor for dose adjustment if you experience weight gain or loss, increased stress, illness, changes in diet such as missed meals or if you are taking alcohol. Your dose may also change if you have recently changed your exercise regime or are taking any medicines. Also, you must be vigilant for certain side effects that you may experience while using Lupisulin R 100IU/ml Cartridge. Your doctor will tell you ways to prevent them. These side effects are usually temporary but if they are very severe, you may need dose modifications.
Q. Does Lupisulin R 100IU/ml Cartridge need to be refrigerated?
Lupisulin R 100IU/ml Cartridge needs to be refrigerated before its first use. Unopened cartridges and unused pre-filled pens of Humalog must be stored in a refrigerator where the temperature is between 2°C to 8°C. Do not freeze and do not use Lupisulin R 100IU/ml Cartridge if it has been frozen. When the cartridge has been inserted into the injection pen, it should not be refrigerated and should be kept at room temperature, below 86°F (30°C) and must be used within 28 days or be discarded, even if they still contain Lupisulin R 100IU/ml Cartridge.
Q. What is Lupisulin R 100IU/ml Cartridge? How is it made?
Lupisulin R 100IU/ml Cartridge is a man-made version of human insulin, produced by the process of biotechnology called recombinant DNA technology. It is sold as a sterile, aqueous, clear, and colorless solution that contains insulin aspart along with other constituents like glycerin, phenol, metacresol, zinc, sodium chloride etc.
