Manufacturer: Glenmark Pharmaceuticals Ltd
Salt Composition : Fluconazole(150mg)
Markzole 150mg Tablet should be taken in the dose and duration as prescribed by your doctor. It should be swallowed whole and can be taken with or without food. The dosage and length of treatment will depend on the condition you are being treated for. Sometimes this will be in cycles of use and non-use. To get the most benefit, take this medicine at evenly spaced times and continue using it until your prescription is finished, even if your symptoms disappear after a few days. If you stop treatment too early, the infection may return and if you miss doses you can increase your risk of infections that are resistant to further treatment. Tell your doctor if the infection does not get better or if it gets worse. Avoid taking antacid treatments within one hour before or two hours after you take it.
Fluconazole interacts with 14-demethylase, a cytochrome P-450 enzyme responsible for catalyzing the conversion of lanosterol to ergosterol. [4] As ergosterol forms a critical part of the fungal cell membrane, fluconazole inhibits the synthesis of ergosterol to increase cellular permeability.
The pharmacokinetics of fluconazole are similar following intravenous and oral dosing. Oral bioavailability is greater than 90%, and concentrations peak approximately 2 hours after dosing. The apparent volume of distribution is 0.7 L/kg, and plasma protein binding is low (12%).
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Markzole
Headache
Nausea
Stomach pain
low amount of magnesium in the blood.
low amount of potassium in the blood.
torsades de pointes, a type of abnormal heart rhythm.
prolonged QT interval on EKG.
abnormal EKG with QT changes from birth.
abnormal liver function tests.
pregnancy.
chronic kidney disease stage 3A (moderate)
Markzole 150mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Caution is advised when consuming alcohol with Markzole 150mg Tablet. Please consult your doctor.
Markzole 150mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Fluconazole is an antifungal medicine. It's used to treat infections caused by different kinds of fungus. The most common cause of fungal infections is a yeast called candida.
Alfuzosin.
Amiodarone.
Aripiprazole.
Aripiprazole Lauroxil.
Artemether.
Atazanavir.
Bedaquiline.
Bepridil.
Do not chew, crush or break it. Markzole 150mg Tablet may be taken with or without food
Store below 30°C
If you miss a dose of Markzole 150mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Your doctor has prescribed Markzole 150mg Tablet to cure your infection and improve symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better.
Use a reliable method of contraception to prevent pregnancy while taking this medicine.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Inform your doctor if you develop severe skin rash like blistering of the skin along with fever.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Markzole 150mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. What is Markzole 150mg Tablet used for?
Markzole 150mg Tablet is an antifungal medicine. It is used for the treatment of many fungal infections like Cryptococcal meningitis (fungal infection in the brain) and Coccidioidomycosis (a disease of the lungs). Additionally, it is helpful in the treatment of infections caused by Candida found in the bloodstream, body organs (e.g., heart, lungs) or urinary tract, mucosal thrush (infection affecting the lining of the mouth, throat, and denture sore mouth), and genital thrush (infection of the vagina or penis). It can also be used to treat skin infections like athlete's foot, ringworm, jock itch, nail infection.
Q. Can Markzole 150mg Tablet be taken with oral contraceptives (OCPs) or birth control pills?
Markzole 150mg Tablet has been reported to have a minor interaction when taken with estradiol (a component of oral contraceptives). It can increase the level or effect of estradiol when given along with it. Before starting the treatment with Markzole 150mg Tablet inform your doctor if you are taking birth control pills.
Q. Can Markzole 150mg Tablet cause hair loss?
Markzole 150mg Tablet may cause hair loss as a rare side effect. If during the treatment you experience hair loss, inform your doctor.
Q. Is Markzole 150mg Tablet effective?
Yes, Markzole 150mg Tablet is effective when used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Markzole 150mg Tablet too early, the symptoms may return or worsen.
