Manufacturer: Emcure Pharmaceuticals Ltd
Salt Composition : Melphalan(50mg)
Megval 50mg Injection is given as an injection into veins by the doctor, but try to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes skin more sensitive towards sunlight, wear protective clothing or use sunscreen.
The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells) and hair loss. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Inform your doctor if you observe signs of infections such as fever, chills, body ache or if you have unusual bruising or bleeding and bleeding gums or blood in your urine or stool.
Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Megval 50mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
About 5.8% to 21.3% of melphalan is excreted in urine. In patients given a single oral dose of 0.6 mg/kg of melphalan, the terminal elimination plasma half-life (± SD) was 1.5 ± 0.83 hours. Following intravenous administration, the terminal elimination half-life is approximately 75 minutes.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Megval
Nausea
Vomiting
Stomatitis (Inflammation of the mouth)
Anemia (low number of red blood cells)
Hair loss
Low blood platelets
Diarrhea
Decreased white blood cell count
Melphalan for use with the hepatic delivery system is contraindicated in patients with uncorrectable coagulopathy, active brain metastases or brain lesions that may bleed, or who have had surgery or medical treatment involving the liver within the previous 4 weeks.
Megval 50mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Caution is advised when consuming alcohol with Megval 50mg Injection. Please consult your doctor.
Megval 50mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Melphalan is an antineoplastic agent that acts as a bifunctional alkylating agent. It is used in the treatment of multiple myeloma, advanced ovarian adenocarcinoma, early and advanced breast cancer, childhood neuroblastoma, and polycythaemia vera.
The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Melphalan. The risk or severity of adverse effects can be increased when Adalimumab is combined with Melphalan. The risk or severity of infection can be increased when Adenovirus type 7 vaccine live is combined with Melphalan.
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
If you miss a dose of Megval 50mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Megval 50mg Injection should be taken as per dose and duration suggested by the doctor.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
