Midacip Nasal Spray (5ml)

Manufacturer: Cipla Ltd

Salt Composition : Midazolam(0.5mg)


Midacip Nasal is taken under the supervision of a healthcare professional only or used after the proper guidance of a doctor. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming.

If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly without talking to your doctor as it may cause nausea and anxiety.

Side effects of this medicine include sleepiness, headache, nasal discomfort, throat irritation, and rhinorrhea (runny nose). Do not drive or do anything that requires mental focus until you know how this medicine affects you. These side effects are usually short-lasting and resolve on their own. Consult your doctor if they bother you or do not go away.  Do inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.


Basic Information

Mechanism Of Action

Midacip Nasal is a benzodiazepine (BZD). It is rapidly absorbed into the bloodstream through the inner lining of the nose. Once absorbed, it works by increasing the action of GABA, a chemical messenger that suppresses the abnormal and excessive activity of the nerve cells in the brain. This helps the patient to recover from a seizure faster.

Pharmacokinets

The pharmacokinetic variables of midazolam reveal that it is cleared significantly more rapidly than diazepam and lorazepam. The rapid redistribution of midazolam and high rate of liver clearance account for its relatively short hypnotic and hemodynamic effects.


Side Effects

Sleepiness

Headache

Nasal discomfort

Throat irritation

Runny nose

Contra Indications

midazolam is contraindicated in patients with a known hypersensitivity to the drug. Benzodiazepines are contraindicated in patients with acute narrow-angle glaucoma. Benzodiazepines may be used in patients with open-angle glaucoma only if they are receiving appropriate therapy.

Pregnancy Related Information

Midacip Nasal is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Product And Alcohol Interaction

No interaction found/established

Breast Feeding Related Information

Midacip Nasal is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Midacip Nasal should be used for short periods and sleepiness of the baby should be watched. The withdrawal of Midacip Nasal should be gradual.

Indications

Intravenous midazolam is used for the induction of anesthesia and also in the management of acute seizures. Because of its water-soluble nature, midazolam has a rapid onset of action and can be used to manage status epilepticus when intravenous administration of other medications is not feasible.

Interactions

Drug-Drug Interaction: Inform your doctor if you are taking high blood pressure-lowering medicines (diltiazem, nifedipine, verapamil), antifungals (fluconazole, ketoconazole, voriconazole, itraconazole, posaconazole), antibiotics (clarithromycin, erythromycin, roxithromycin, rifampicin), high cholesterol-lowering medicines (atorvastatin), medicines for HIV/AIDS (saquinavir), anticonvulsants (phenytoin, carbamazepine), opioid pain killers (fentanyl), anti-allergic medicines, antianxiety drug (diazepam), antidepressants, and other medicines.

Drug-Food Interaction: MIDAZOLAM may interact with grapefruit. Therefore, avoid intake of grapefruit or grapefruit juice with MIDAZOLAM as it may increase the adverse effects of MIDAZOLAM. Also, avoid alcohol consumption with MIDAZOLAM as it may increase the sedative effect. Inform your doctor if you are taking St. John's wort (a herbal medicine).

Drug-Disease Interaction: If you have a lung or breathing disorder, myasthenia gravis (muscle weakness), history of drug abuse or personality disorder, or kidney, liver or heart problems, inform your doctor before taking MIDAZOLAM.

Drug-Drug Interactions Checker List:

DILTIAZEM

NIFEDIPINE

VERAPAMIL

FLUCONAZOLE

KETOCONAZOLE

VORICONAZOLE

ITRACONAZOLE

POSACONAZOLE

CLARITHROMYCIN

ERYTHROMYCIN

ROXITHROMYCIN

RIFAMPICIN

ATORVASTATIN

SAQUINAVIR

PHENYTOIN

CARBAMAZEPINE

FENTANYL

DIAZEPAM

Typical Dosage

Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.

Storage Requirements

Store below 30°C

Effects Of Missed Dosage

If you miss a dose of Midacip Nasal , take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

Effects Of Overdose

Consult a doctor before taking any medicines.

Expert Advice

The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor

It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.

Avoid consuming alcohol as it may increase dizziness and drowsiness.

Inform your doctor if you are pregnant, planning to conceive or breastfeeding.

Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

How To Use

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.


FAQs

Q. Is Midacip Nasal safe?

Midacip Nasal is safe if used at prescribed doses for the prescribed duration as advised by your doctor

Q. Is Midacip Nasal a controlled substance?

Yes, Midacip Nasal is a controlled substance