Manufacturer: Mankind Pharma Ltd
Salt Composition : Sodium Valproate(133mg), Valproic Acid(58mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Napilex CR 133mg/58mg Tablet should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, swelling of gums, headache, sleepiness, tremor, hair loss and liver injury. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.
Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your doctor know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Napilex CR 133mg/58mg Tablet can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.
You should avoid alcohol while taking Napilex CR 133mg/58mg Tablet, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Valproic acid exhibits its pharmacologic effects in a couple of ways, such as by acting on GABA (γ aminobutyric acid) levels in the CNS, blocking voltage-gated ion channels, and inhibiting histone deacetylase.
Valproic acid is rapidly absorbed from the gastrointestinal tract, peak concentrations being attained 1 to 2 hours after administration of the conventional tablet, but later with the enteric-coated tablets. The bioavailability of valproic acid is complete and independent of the preparation used.
Valproic acid is present in cerebrospinal fluid in concentrations equal to the unbound drug in plasma (around 10% of the total concentration). Valproic acid concentration in saliva is less than and unrelated to the free drug concentration in plasma.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Napilex CR
Nausea
Vomiting
Weight gain
Loss of appetite
Gum swelling
Headache
Sleepiness
Tremors
Hair loss
Liver injury
Serious or fatal hepatic failure has been reported during the first six months of treatment. ...
The use of valproic acid in patients with mitochondrial disease (POLG-related Mitochondrial disorders) has been demonstrated to increase the risk of hepatotoxicity and death.
Napilex CR 133mg/58mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Napilex CR 133mg/58mg Tablet.
Napilex CR 133mg/58mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Sodium valproate is used to treat epilepsy and bipolar disorder. It's occasionally used to prevent migraine headaches. This medicine is only available on prescription. It comes as capsules, tablets and a liquid that you swallow.
Some products that may interact with this drug include: certain antidepressants (such as amitriptyline, nortriptyline, phenelzine), certain antibiotics (carbapenems such as imipenem), irinotecan, mefloquine, orlistat, other medications for seizure (such as ethosuximide, lamotrigine, rufinamide, topiramate), vorinostat
Do not chew, crush or break it. Napilex CR 133mg/58mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Napilex CR 133mg/58mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Napilex CR 133mg/58mg Tablet for treatment and prevention of seizures.
Take it at the same time every day to maintain consistent levels in your body.
Do not drive or do anything that requires mental focus until you know how Napilex CR 133mg/58mg Tablet affects you.
Avoid consuming alcohol when taking Napilex CR 133mg/58mg Tablet, as it may cause excessive sleepiness or drowsiness.
Monitor your weight during the treatment as Napilex CR 133mg/58mg Tablet can cause weight gain.
Your doctor may monitor Napilex CR 133mg/58mg Tablet level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin.
Do not take Napilex CR 133mg/58mg Tablet if you are pregnant or planning to conceive or breastfeeding.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Napilex CR 133mg/58mg Tablet is to be taken with food.
Q. Can the use of Napilex CR 133mg/58mg Tablet cause sleepiness or drowsiness?
Yes, Napilex CR 133mg/58mg Tablet may make you feel drowsy or sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities. Inform your doctor if you experience such an episode while taking this medicine.
Q. Can I drink alcohol while taking Napilex CR 133mg/58mg Tablet?
No, avoid drinking alcohol while taking Napilex CR 133mg/58mg Tablet. Drinking alcohol will increase the side effects caused by Napilex CR 133mg/58mg Tablet.
Q. Can Napilex CR 133mg/58mg Tablet be stopped when epilepsy symptoms are relieved?
No, Napilex CR 133mg/58mg Tablet should be continued as advised by the doctor. Stopping Napilex CR 133mg/58mg Tablet suddenly may cause the symptoms to reappear that too with increased frequency. If any problems are experienced due to Napilex CR 133mg/58mg Tablet, consult the doctor for re-evaluation.
Q. Will a higher than the recommended dose of Napilex CR 133mg/58mg Tablet be more effective?
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects and toxicity. If the recommended doses do not relieve your symptoms or there is an increased severity of your symptoms, please consult your doctor.
