Manufacturer: Abbott
Salt Composition : Vinorelbine(50mg)
Navelbine 50mg Injection is an anti-cancer medication used in the treatment of breast cancer and non-small cell lung cancer.
It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, weakness, fatigue, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Men are advised to seek guidance and counselling on sperm conservation before taking this therapy.
Vinorelbine is a second-generation, semisynthetic vinca alkaloid. Its mechanism of action is through binding to microtubular proteins in the mitotic spindle, thereby preventing cell division during metaphase
The pharmacokinetic profile of vinorelbine is often described as a 3-compartment model characterised by a long terminal half-life (t1/2) that varies between 20 and 40 hours and a large apparent volume of distribution (Vd) of around 70 L/kg
Nausea
Vomiting
Weakness
Fatigue
Hair loss
Low blood platelets
Increased liver enzymes
Fever
Anemia (low number of red blood cells)
Bleeding
Constipation
an infection.
anemia.
decreased blood platelets.
low levels of a type of white blood cell called neutrophils.
a painful condition that affects the nerves in the legs and arms called peripheral neuropathy.
a type of inflammation of the lung called interstitial pneumonitis.
Navelbine 50mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Navelbine 50mg Injection. Please consult your doctor.
Navelbine 50mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Vinorelbine is indicated in adults in the treatment of: - Non-small cell lung cancer (stage 3 or 4). - As single agent to patients with metastatic breast cancer (stage 4), where treatment with anthracycline- and taxane containing chemotherapy has failed or is not appropriate.
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Your doctor or nurse will give you this medicine
Store in a refrigerator (2 - 8°C). Do not freeze.
Consult a doctor before taking any medicines.
Navelbine 50mg Injection is given as an injection into the vein under the supervision of a doctor.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
Inform your doctor if you experience skin rash, swelling of face or lips and trouble breathing.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
