Manufacturer: Torrent Pharmaceuticals Ltd
Salt Composition : Buprenorphine(0.3mg)
Vial of 2ml Injection
(Inclusive of all taxes)
Norphin 0.3mg Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should continue receiving the medicine until the doctor tells you it is alright to stop.
The most common side effects of this medicine include weakness, drug withdrawal syndrome, anxiety, nervousness, dizziness, headache, sleepiness, diarrhea, nausea, vomiting, and abdominal pain. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Before using it, you should let your doctor know if you have any respiratory disorders, problems with your heart, liver, or kidneys. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.
If you are pregnant or breastfeeding, it is important to ask the advice of your doctor before taking this medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.
Norphin 0.3mg Injection is a opioid partial agonist that provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.
Buprenorphine undergoes metabolism by cytochrome CYP3A4 enzymes after it enters the body and forms an active metabolite, norbuprenorphine, with weak intrinsic activity. The average half-life of buprenorphine is approximately 38 hours, which ranges from 25 to 70 hours after sublingual administration.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Norphin
Weakness
Anxiety
Nervousness
Dizziness
Drug withdrawal syndrome
Headache
Sleepiness
Diarrhea
Nausea
Vomiting
Abdominal pain
Buprenorphine is contraindicated for patients in circulatory shock. The potential for overdose leading to coma or death exists when opioid-naive individuals combine diverted buprenorphine with benzodiazepines, alcohol, or other centrally acting agents.
Norphin 0.3mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Norphin 0.3mg Injection.
Norphin 0.3mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Buprenorphine has three FDA indications: opioid detoxification, opioid maintenance, and pain management. Opioid detoxification describes the process in which a physically dependent individual is gradually tapered off all opioids.
Drug-Drug Interaction: BUPRENORPHINE may have interaction with benzodiazepines (diazepam, temazepam ), pain killers (pentazocine, nalbuphine, codeine, morphine), anti-depressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline), antihistamine (promethazine, chlorphenamine), blood thinners (warfarin), anti-anxiety drugs (alprazolam), fits related medicines (carbamazepine), medicines used to prevent nausea (ondansetron), antifungal drugs (ketoconazole), antibiotic (ciprofloxacin, erythromycin), anticancer drugs (ceritinib, lapatinib), immunosuppressants (fingolimod), antipsychotics (droperidol), and HIV/AIDS drugs (saquinavir).
Drug-Food Interaction: BUPRENORPHINE may interact with grapefruit juice. Therefore, avoid grapefruit juice intake with BUPRENORPHINE as it may increase BUPRENORPHINE levels in the body. Also, avoid St. John's wort (antidepressants plant), and alcohol consumption while receiving BUPRENORPHINE as it may increase the risk of adverse effects such as drowsiness, dizziness and difficulty concentrating.
Drug-Disease Interaction: People with asthma or any other breathing problems, kidney problems, liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression should consult a doctor before receiving BUPRENORPHINE.
Drug-Drug Interactions Checker List:
DIAZEPAM
TEMAZEPAM
PENTAZOCIN
CODEINE
DIHYDROCODEINE
METHADONE
MORPHINE
MOCLOBEMIDE
TRANYLCYPROMINE
CITALOPRAM
ESCITALOPRAM
FLUOXETINE
FLUVOXAMINE
PAROXETINE
SERTRALINE
DULOXETINE
VENLAFAXINE
AMITRIPTYLINE
DOXEPIN
TRIMIPRAMINE
PROMETHAZINE
CHLORPHENIRAMINE
WARFARIN
ALPRAZOLAM
CARBAMAZEPINE
ONDANSETRON
KETOCONAZOLE
CIPROFLOXACIN
ERYTHROMYCIN
CERITINIB
LAPATINIB
FINGOLIMOD
DROPERIDOL
SAQUINAVIR
Store below 30°C
Consult a doctor before taking any medicines.
Consult a doctor before taking any medicines.
Norphin 0.3mg Injection is given as an injection by healthcare professionals only.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Use caution while driving or doing anything that requires concentration as Norphin 0.3mg Injection can cause dizziness and sleepiness.
Avoid drinking alcohol or taking other medicines that can cause drowsiness.
Discontinue the medicine and inform your doctor if you experience difficulty breathing.
Do not stop taking Norphin 0.3mg Injection without talking to your doctor first as it may cause a worsening of symptoms.
Your doctor may get regular blood tests to check for liver function while taking this medicine.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What is Norphin 0.3mg Injection used for?
Norphin 0.3mg Injection is used to relieve severe pain when other pain medicines did not work well enough or cannot be tolerated. This medicine is not used for minor pain or pain that only sometimes occurs. It should not be used to treat pain that you only have once in a while or "as needed". It is also used to treat opioid use disorder.
Q. How is Norphin 0.3mg Injection given?
This medicine should be injected into the skin and never into a vein. Injecting Norphin 0.3mg Injection into a vein or muscle could result in damage to the skin or underlying tissues, as well as a blood clot that could be fatal.
Q. How fast Norphin 0.3mg Injection start to work after IV (intravenous) administration?
The analgesic (pain-relieving) effect after IV administration usually occurs within 10-30 minutes and the peak effects occur within 60 minutes.
Q. How long the analgesic effect of Norphin 0.3mg Injection lasts?
The analgesic effect of Norphin 0.3mg Injection usually lasts for an average of six hours but the duration may vary between individuals.
