Manufacturer: MSD Pharmaceuticals Pvt Ltd
Salt Composition : Posaconazole(40mg)
Noxafil Oral Suspension should be taken in the dose and duration as prescribed by your doctor. They should be swallowed whole and taken with food. The dosage and length of treatment will depend on the condition you are being treated for. Sometimes this will be in cycles of use and non-use. To get the most benefit, take this medicine at evenly spaced times and continue using it until your prescription is finished, even if your symptoms disappear after a few days. If you stop treatment too early, the infection may return and if you miss doses you can increase your risk of infections that are resistant to further treatment. Tell your doctor if the infection does not get better or if it gets worse.
The most common side effects of this medicine include headache, diarrhea, feeling sick (nausea), and low potassium level. These are not usually serious, but you should call your doctor if you think you might have a severe allergic reaction and sign of liver problems such as yellowing of eyes, dark urine, and stomach problems. Get emergency help if this happens.
Do not take it if you are pregnant or could become pregnant unless your doctor has told you to. Talk to your doctor before taking it if you have ever had heart failure, kidney problems, or liver problems such as yellow skin (jaundice). This medicine may not be suitable for you. If your course of treatment is for more than a month, your doctor may want to check your liver, and potassium level by testing your blood. The drugs may make you dizzy or have blurred vision so do not drive or operate machines until it is safe.
Noxafil Oral Suspension is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.
The absorption of posaconazole is significantly increased when administered with a (high-fat) meal [7]. Several studies have shown subtherapeutic posaconazole concentrations in patients with no or limited food intake or after administration by nasogastric tube [8–10].
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Noxafil
Headache
Rash
Decreased appetite
Decreased white blood cell count (neutrophils)
Dizziness
Electrolyte imbalance
Fatigue
Fever
Decreased potassium level in blood
Increased liver enzymes
Insomnia (difficulty in sleeping)
Itching
Sleepiness
Taste change
Weakness
Decreased magnesium level in blood
Paresthesia (tingling or pricking sensation)
High blood pressure
Anorectal discomfort
Increased glucose level in blood
Hypoglycemia (low blood glucose level)
Hypotension (low blood pressure)
Nausea
Diarrhea
Anemia (low number of red blood cells)
Low blood platelets
Petechiae (red or purple spot caused by bleeding into the skin)
Vomiting
Cough
Abdominal pain
Constipation
Indigestion
Nosebleeds
Rigors
Swelling of legs
Breathlessness
Contraindications : Co-administration with sirolimus, ergot alkaloids, HMG-CoA reductase inhibitors that are primarily metabolized through CYP3A4, or CYP3A4 substrates that prolong the QT interval; hypersensitivity to posaconazole, other azole antifungal agents, or any component of the formulation.
Noxafil Oral Suspension may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Noxafil Oral Suspension. Please consult your doctor.
Noxafil Oral Suspension is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Posaconazole Accord is indicated for use in the treatment of the following fungal infections in adults (see section 5.1): - Invasive aspergillosis; - Fusariosis in patients with disease that is refractory to amphotericin B or in patients who are intolerant of amphotericin B; - Chromoblastomycosis and mycetoma in .
There are 560 drugs known to interact with posaconazole, along with 6 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 219 are major, 320 are moderate, and 21 are minor.
Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Noxafil Oral Suspension is to be taken with food.
Store below 30°C
If you miss a dose of Noxafil Oral Suspension, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Your doctor has prescribed Noxafil Oral Suspension to cure your infection and improve symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better.
Take it with food, preferably at the same time every day.
Do not take indigestion remedies (antacids) within two hours of taking Noxafil Oral Suspension.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Noxafil Oral Suspension is to be taken with food.
Q. What is Noxafil Oral Suspension and what is it used for?
Noxafil Oral Suspension belongs to a class of medicines known as antifungal medicines. It is used to treat serious infections caused by various types of fungi such as Aspergillus and Candida, in patients who are at high risk of developing these infections. Noxafil Oral Suspension is majorly prescribed to severely immunocompromised patients in cases of cancer or those undergoing blood transfusion or chemotherapy.
Q. How to take Noxafil Oral Suspension?
Noxafil Oral Suspension should be taken with food to get maximum benefit. Follow your doctor’s instructions carefully and continue taking it in the dose and duration prescribed by the doctor. Do not stop taking it without discussing it with your doctor as it may worsen your symptoms.
Q. I feel better now. Can I stop taking Noxafil Oral Suspension?
No. You should not stop taking Noxafil Oral Suspension without discussing it with your doctor even if you feel better. This is because if you stop taking it suddenly, it may worsen your symptoms and your infection may come back. Your doctor will decide for how long you need to continue taking this medicine. Consult your doctor if any of the side effects bother you. If you have completed your course of treatment, your doctor may decrease your dose gradually before taking you off this medicine. Follow your doctor’s instructions carefully.
Q. What if I forget to take a dose of Noxafil Oral Suspension?
If you have missed a dose of Noxafil Oral Suspension, take it as soon as you remember it. However, if it is almost time for your next dose, take it in the regular schedule instead of taking the missed dose. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
