Manufacturer: Torrent Pharmaceuticals Ltd
Salt Composition : Obeticholic acid(10mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Ocabile 10 Tablet may be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. You should always complete the full course of the medicine as prescribed by your doctor. Do not stop taking it until you have finished.
The most common side effects of this medicine include itching, fatigue, abdominal pain, rash, throat pain, dizziness, constipation, joint pain, eczema, and thyroid disorders. If you experience any of these side effects that does not resolve on its own or get worse, you should let your doctor.
Before taking the medicine, tell your doctor if you have any other medical conditions. You should also let your doctor know about all the other medicines you are taking (if any), as they may affect or be affected by this medicine. Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Ocabile 10 Tablet stimulates Farnesoid X receptor (FXR), a chemical that regulates synthesis and transport of bile acid, lipid metabolism and regulation of glucose levels. Ocabile 10 Tablet inhibits bile acid synthesis and increases bile acid secretions. This reduces the bile acid pool in the liver and hence prevents its toxic effects. Therefore, it helps to improve liver function.
Obeticholic acid is conjugated with glycine or taurine, followed by secretion into bile. The conjugates are then absorbed in the small intestine and then re-enter the liver via enterohepatic circulation.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ocabile
Itching
Fatigue
Abdominal pain
Abdominal discomfort
Throat pain
Rash
Joint pain
Oropharyngeal pain
Dizziness
Constipation
Peripheral edema
Palpitations
Fever
Thyroid disorders
Eczema
Obeticholic acid is contraindicated in patients with complete biliary obstruction. Inhibitors of the bile salt efflux pump (BSEP) such as cyclosporine should normally be avoided when the patient takes OCA to prevent the buildup of conjugated bile salts in the liver.
Information regarding the use of Ocabile 10 Tablet during pregnancy is not available. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Ocabile 10 Tablet. Please consult your doctor.
Information regarding the use of Ocabile 10 Tablet during breastfeeding is not available. Please consult your doctor.
Obeticholic acid is used alone or in combination with ursodiol (Actigall, Urso) to treat primary biliary cholangitis (PBC; a type of liver disease that destroys bile ducts, which allows bile to stay in the liver and cause damage) in people who cannot take ursodiol or in people who were not treated successfully with ..
Drug-Drug Interactions: OBETICHOLIC ACID may interact with xanthines (theophylline), muscle relaxants (tizanidine), blood thinners (warfarin), bile acid sequestrants (cholestyramine, colestipol, colesevelam).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have biliary obstruction, liver impairment, or lipid disorder.
Drug-Drug Interactions Checker List:
THEOPHYLLINE
TIZANIDINE
WARFARIN
CHOLESTYRAMINE
COLESTIPOL
COLESEVELAM
Do not chew, crush or break it. Ocabile 10 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
Consult a doctor before taking any medicines.
Consult a doctor before taking any medicines.
Ocabile 10 Tablet is used for the treatment of primary biliary cirrhosis.
Your liver function will be monitored closely while on treatment with Ocabile 10 Tablet.
Eat a well-balanced diet and indulge in some sort of physical activity daily in order to reduce fatigue and improve well-being.
Itching is one of the common side effects of Ocabile 10 Tablet. Follow these tips to manage itching:
a) Keeping cool will also tend to reduce itch, compared to being warm. Cool showers or cold flannels may be helpful.
b)Dry skin can make the itch worse, so using liberal amounts of moisturizer is useful if you have dry skin.
c) Do not scratch as scratching will generally make it worse. If scratching is irresistible it may help to rub the itchy area with an ice cube.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ocabile 10 Tablet may be taken with or without food, but it is better to take it at a fixed time.
