Manufacturer: Gentech Healthcare Pvt Ltd
Salt Composition : Naproxen(250mg), Domperidone(10mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Pacinac NP 250mg/10mg Tablet may be prescribed alone or in combination with another medicine. It can be taken with or without food. The dose and duration will depend on the severity of your condition and how well it helps your symptoms. Use it regularly and do not discontinue using it until the doctor tells you it is alright to stop.
Using of the medicine may cause few common side effects such as flu-like symptoms, indigestion, and dryness in the mouth. If you experience any such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. In general, you should try to use the smallest amount necessary to control your symptoms.
Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other medicines you are using so let your doctor know all the other medicines you are taking. It should be used with caution in patients who are alcoholics or have liver or kidney disease. Pregnant and breastfeeding women should consult their doctors first before using the medicine.
Naproxen is an anti-inflammatory (reduce inflammation) and analgesic (reduce pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty stomach.
PHARMACOKINETICS Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed, resulting in higher peak plasma levels for a given dose. Approximately 30% of the total naproxen sodium dose in NAPRELAN® Tablets is present in the dosage form as an immediate release component.
Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pacinac NP
Flu-like symptoms
Indigestion
Dryness in mouth
If you are allergic to naproxen, domperidone, or any other ingredients of naproxen, domperidone Tablet.
If you have an allergy to painkillers like aspirin or ibuprofen. If you are not sure what these medicines are, please confirm with your doctor.
If you have a history of ulcers or bleeding.
If you have any problems with your heart, liver, or kidney.
If you're pregnant or think you may be pregnant or breastfeeding.
If you have a pituitary gland tumour that releases an excess of prolactin hormone (prolactinoma).
If you have an obstruction, blockage, or perforation (tear) in the intestine or any part of the gut.
If you have any condition due to which there is a salt imbalance in your body (low levels of potassium or magnesium or high level of potassium).
Pacinac NP 250mg/10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Pacinac NP 250mg/10mg Tablet.
Pacinac NP 250mg/10mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
It is primarily used in the treatment of migraine headaches. It can also treat pain associated with rheumatoid arthritis, arthritis, gout, dysmenorrhea (menstrual pain), and muscle and bone disorders, such as back pain, sprains, and strains.
Drug-disease interactions: DOMPERIDONE+NAPROXEN SODIUM may interact with disease conditions, including asthma, fluid retention (Congestive Heart Failure, Hypertension), GI toxicity (Gastrointestinal Haemorrhage, Gastrointestinal Perforation, Gastritis), rash, renal toxicities (Renal Dysfunction), and thrombosis
Do not chew, crush or break it. Pacinac NP 250mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Pacinac NP 250mg/10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Pacinac NP 250mg/10mg Tablet for prevention of migraine headaches.
Do not take it to treat an acute attack of migraine.
Some tips that may help avoid a migraine attack:
Have your meals at the same time everyday
Avoid bright lights and extreme temperatures
Avoid loud music and noisy places
Avoid chocolates, cheese, processed food, alcohol and smoking
Get enough sleep and avoid stress
It may cause sleepiness. Do not drive or do anything that requires mental focus until you know how Pacinac NP 250mg/10mg Tablet affects you.
Avoid consuming alcohol as it may cause new and worse headaches.
Keep taking it every day, as prescribed by your doctor, even if you do not have any symptoms.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pacinac NP 250mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. What is Pacinac NP 250mg/10mg Tablet?
Pacinac NP 250mg/10mg Tablet is a combination of two medicines: Naproxen and Domperidone. This combination helps in relieving the symptoms of migraine like headache, nausea and vomiting. Naproxen is a pain-killer that blocks the release of certain chemical messengers that cause headache. Domperidone is an anti-emetic agent (prokinetic). It increases the movement of the stomach and intestines, allowing food to move more easily through the stomach. This helps in relieving vomiting.
Q. Can I stop taking Pacinac NP 250mg/10mg Tablet when my migraine symptoms are relieved?
No, do not stop taking Pacinac NP 250mg/10mg Tablet until advised by your doctor.
Q. Can the use of Pacinac NP 250mg/10mg Tablet cause diarrhea?
Yes, the use of Pacinac NP 250mg/10mg Tablet can cause diarrhea. In case, you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less urination with dark coloured and strong-smelling urine. Do not take any other medicine without consulting a doctor.
Q. Are there any specific contraindications associated with the use of Pacinac NP 250mg/10mg Tablet?
The use of Pacinac NP 250mg/10mg Tablet is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine or in patients with known allergy to other painkillers (NSAIDs). The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with history of heart failure, high blood pressure, and liver or kidney disease.
