Manufacturer: Panacea Biotec Ltd
Salt Composition : Paclitaxel(100mg)
It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Some common side effects of this medicine include nausea, vomiting, and weakness. It may also cause serious side effects such as swelling of hands, lips, hair loss, and weight gain. To reduce these side effects your doctor may suggest some medication along with it. But, inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever). This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells and liver function.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Mechanism of action of paclitaxel. Paclitaxel targets microtubules. At high concentration, PTX causes mitotic arrest at G2/M phase whereas at low concentration, apoptosis is induced at G0 and G1/S phase either via Raf-1 kinase activation or p53/p21 depending on the dose concentration.
Paclitaxel is a new anticancer agent showing significant promise as therapy for solid tumours and leukaemia, given alone or in combination with other chemotherapeutic agents. Paclitaxel concentrations in biological specimens can be measured using high performance liquid chromatography, or more recently by immunoassay.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Paclitrust
Nausea
Vomiting
Weakness
Low blood platelets
Rash
Upper respiratory tract infection
Urinary tract infection
Bleeding
Anemia (low number of red blood cells)
Flushing (sense of warmth in the face, ears, neck and trunk)
Hair loss
Decreased blood pressure
Peripheral neuropathy (tingling and numbness of feet and hand)
Diarrhea
Decreased white blood cell count (neutrophils)
Paclitaxel is contraindicated in patients who have a history of severe paclitaxel hypersensitivity; those patients with a history of other taxane hypersensitivity should be given paclitaxel with caution. A risk of serious hypersensitivity reactions or anaphylaxis has been reported in patients receiving paclitaxel.
Paclitrust 100mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is unsafe to consume alcohol with Paclitrust 100mg Injection.
Paclitrust 100mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Adjuvant treatment for node-positive breast cancer
Treatment of metastatic breast cancer after failure of combination chemotherapy that included an anthracycline
Treatment of metastatic breast cancer that relapsed within six months of adjuvant chemotherapy that included an anthracycline
Serious interactions of paclitaxel include:
adenovirus types 4 and 7 live, oral.
eluxadoline.
idarubicin.
idelalisib.
influenza virus vaccine trivalent, adjuvanted.
ivacaftor.
nefazodone.
palifermin.
Kindly do not self administer.
Store below 30°C
Paclitrust 100mg Injection is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer, and non-small cell lung cancer.
It is given as an intravenous (IV) injection into your vein, usually over 1 hour and every three weeks.
Do not take Paclitrust 100mg Injection if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells and liver function during treatment with this medicine.
Inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever) or other signs of infection.
Talk to your doctor if you have sudden weight gain or if you have swelling in your arms and legs that doesn't go away.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Paclitrust 100mg Injection generic/ taxane/ FDA approved/cytotoxic?
Yes, Paclitrust 100mg Injection is generic/ taxane/ FDA approved/ cytotoxic
Q. Is Paclitrust 100mg Injection a vesicant?
Paclitrust 100mg Injection is usually a vesicant (irritant)
Q. Is Paclitrust 100mg Injection light sensitive/ hydrophobic/ cardiotoxic?
Yes, Paclitrust 100mg Injection is light sensitive/ hydrophobic/ cardiotoxic
Q. Does Paclitrust 100mg Injection cause hair loss?
Yes, Paclitrust 100mg Injection may cause hair loss as a side effect. Please inform your doctor about any side effect while you are on Paclitrust 100mg Injection therapy
