Manufacturer: Pfizer Ltd
Salt Composition : Palbociclib(125mg)
Palbace 125mg Tablet should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Some common side effects of this medicine include fatigue, hair loss, rash, vomiting, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It is better to inform your doctor if you notice symptoms of infection like fever, chills, and weakness, bleeding or bruising and nose bleed. It might also cause dizziness if it happens avoid driving or attention-seeking activities.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Palbace 125mg Tablet is an anti-cancer medication. Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.
Palbociclib presents a linear pharmacokinetic profile and its peak plasma concentration was observed 6-12 hours after oral administration. The oral bioavailability is reported to be of 46% with a steady-state reached after 8 days and a median accumulation ratio of 2.4.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Palbace
Decreased blood cells (red cells, white cells, and platelets)
Fatigue
Hair loss
Rash
Vomiting
Diarrhea
Nausea
Decreased appetite
Infection
Decreased white blood cell count
Stomatitis (Inflammation of the mouth)
Anemia (low number of red blood cells)
Weakness
Fever
If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Interstitial lung disease or pneumonitis can occur while using this medicine.
Palbace 125mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Palbace 125mg Tablet. Please consult your doctor.
Palbace 125mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
indicated for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in combination with: an aromatase inhibitor as initial endocrine-based therapy; or.
Drug-DrugInteractions: PALBOCICLIB may interact antiviral/anti-HIV drug (lopinavir, ritonavir, nelfinavir, telaprevir, saquinavir), antidepressant (St John’s wort and nefazodone), antifungals (voriconazole, itraconazole, ketoconazole, posaconazole), antibiotics (clarithromycin, telithromycin) anti-rheumatoid drug (abatacept), heart medicine (quinidine), anti-gout medicine (colchicine), anaesthetics (alfentanyl and fentanyl), immunosuppressants (tacrolimus, cyclosporine), antipsychotics (pimozide) and anti-migraine drugs (dihydroergotamine, ergotamine).
Drug-Food Interactions: PALBOCICLIB may interact with grapefruit and grapefruit juice.
Drug-Disease Interactions: PALBOCICLIB should be used with caution in patients with a known hypersensitivity disorder, HIV, epilepsy, lactose intolerance, kidney disease, liver disease, lung or breathing disorders, hypertension, diabetes, heart disease, gout or a disease of the veins.
Drug-Drug Interactions Checker List:
RITONAVIR
NELFINAVIR
SAQUINAVIR
LOPINAVIR
TELAPREVIR
ITRACONAZOLE
KETOCONAZOLE
VORICONAZOLE
POSACONAZOLE
CLARITHROMYCIN
TELITHROMYCIN
ABATACEPT
QUINIDINE
COLCHICINE
ALFENTANIL
FENTANYL
TACROLIMUS
CYCLOSPORINE
PIMOZIDE
ERGOTAMINE
Do not chew, crush or break it. Palbace 125mg Tablet is to be taken with food.
Consult a doctor before taking any medicines.
Consult a doctor before taking any medicines.
Take it with food, preferably at the same time every day.
If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
Use effective contraception method to prevent pregnancy while taking this medicine.
It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Do not stop taking the medication without talking to your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Palbace 125mg Tablet is to be taken with food.
Q. What kind of medicine is Palbace 125mg Tablet?
Palbace 125mg Tablet is an anti-cancer medicine. Palbace 125mg Tablet blocks proteins known as cyclin-dependent kinase inhibitors. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer.
Q. How long do I have to take Palbace 125mg Tablet?
The duration of treatment varies from person to person. Your doctor will decide the number of cycles you need to receive based on your condition, response to treatment and your tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience certain side effects.
Q. Are the side effects of Palbace 125mg Tablet irreversible?
No, most of the side effects are reversible and disappear when the medicine is stopped. Neutropenia is a well-recognized adverse effect of Palbace 125mg Tablet in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection while you are taking Palbace 125mg Tablet. However, this side effect disappears rapidly once you stop taking the medicine.
Q. Does treatment with Palbace 125mg Tablet require monitoring of blood counts?
Yes, blood tests are important since this medicine can lower your blood counts. The regular blood tests check the effect of Palbace 125mg Tablet on your blood cells (white blood cells, red blood cells, and platelets). These tests should be done at the beginning of each chemotherapy cycle, on the 15th day of the first 2 cycles, and as clinically indicated.
