Manufacturer: Cipla Ltd
Salt Composition : Pamidronate(90mg)
Pamidria 90mg Injection is given by a doctor or nurse. You will not need to do this yourself. How much you are given, and how often, will be decided by your doctor. It may just be a single injection but if you are being treated for bone problems caused by the spread of cancer you may need regular injections. Your doctor will ask you to drink plenty of water before the injection, to avoid getting dehydrated. It may take several days to get the full benefit of this drug. Pamidria 90mg Injection is only part of a program of treatment that may also include changes to your diet and taking calcium and vitamin supplements.
The most common side effects include headache, back pain, muscle pain, indigestion, diarrhea, and heartburn. These are usually mild and will disappear after a short time. If they do not go away, tell your doctor. Pamidria 90mg Injection can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine (water pills), or if you already have kidney disease. It can also cause low levels of calcium in the blood and pain in the mouth or jaw. These are serious side effects and need urgent medical attention. Tell your doctor straight away.
You should not be given this medicine if you are breastfeeding. Before taking it, tell your doctor if you have kidney problems or low calcium levels. Also, let your doctor know what other drugs you are taking. Some of them may affect, or be affected by, this injection, especially medicines used to treat severe infections and medicines used to treat cancer and osteoporosis. You may need frequent medical tests to check your kidney function and mineral levels. Avoid smoking or try to quit as smoking can reduce your bone mineral density, making fractures more likely. Drinking large amounts of alcohol can also cause bone loss and should be avoided.
Pamidronate disodium adsorbs to calcium phosphate (hydroxyapatite) crystals in bone and may directly block dissolution of this mineral component of bone. In vitro studies also suggest that inhibition of osteoclast activity contributes to inhibition of bone resorption.
Pamidronate is exclusively eliminated in the urine. By 120 hours after administration, 46±16% of the dose has been eliminated in the urine. The mean elimination half life of pamidronate is 28±7 hours. The mean total clearance of pamidronate is 107±50mL/min and the mean renal clearance is 49±28mL/min.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pamidria
Headache
Back pain
Musculoskeletal (bone, muscle or joint) pain
Heartburn
Diarrhea
Indigestion
Pamidronate disodium is contraindicated in patients with clinically significant hypersensitivity to pamidronate disodium or other bisphosphonates.
Pamidria 90mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Consuming alcohol with Pamidria 90mg Injection does not cause any harmful side effects.
Pamidria 90mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
If you are taking Pamidria 90mg Injection during breastfeeding, monitor the baby's blood calcium levels during the first two months.
Pamidronate is a medication used in the management and treatment of moderate or severe hypercalcemia of malignancy, moderate to severe Paget disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma. It is in the bisphosphonate class of medications.
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calcium acetate.
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calcium chloride.
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calcium gluconate.
dichlorphenamide.
sodium bicarbonate.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Pamidria 90mg Injection, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines.
It is given by injection into a vein, usually over at least 15 minutes or as directed by your doctor.
Drink plenty of fluids to prevent dehydration and kidney damage.
It can lower the level of calcium in the blood. Take calcium and vitamin D supplements as suggested by your doctor.
You may develop fever or flu like symptoms, such as chills, tiredness and weakness. These are usually temporary and should go away after a few days. You may take a pain reliever/fever reducer to prevent or treat these symptoms.
It may cause a rare condition called osteonecrosis of the jaw. Have regular dental check-ups and inform your doctor if you develop sudden pain in your jaw.
Your doctor will monitor your response to Pamidria 90mg Injection by testing your bone mineral density (BMD). This is usually done every 1-3 years.
Do not take it if you are pregnant or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What does Pamidria 90mg Injection do?
Pamidria 90mg Injection helps in preventing breakdown of the bones. Bone is continuously being broken down and regenerated by special kinds of bone cells by a process called remodelling or turnover. However, conditions like bone stress and bone marrow edema may create pain and imbalance in this daily turnover. Pamidria 90mg Injection acts in the areas with increased bone turnover, decreases this process of breakdown and thereby reduces the pain and discomfort associated with it.
Q. How is Pamidria 90mg Injection administered?
Pamidria 90mg Injection should be administered under the supervision of a doctor or a trained healthcare professional and should not be self-administered. It is given as a 1-2 hour infusion by a drip into a vein in your arm. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Pamidria 90mg Injection.
Q. How often will I be given Pamidria 90mg Injection?
Your dose of Pamidria 90mg Injection will be decided by your doctor depending on your condition. Usually, an individual requires 1-3 doses of Pamidria 90mg Injection.However, the exact dose and its frequency will depend on your illness and how well you respond to the treatment.
Q. Is Pamidria 90mg Injection safe in pregnancy or breastfeeding?
No, Pamidria 90mg Injection may not be safe in pregnancy or breastfeeding. Although Pamidria 90mg Injection does not affect the fertility of women or the sperm count in males, it is best to consult your doctor before taking Pamidria 90mg Injection. In general, avoid Pamidria 90mg Injection if you are pregnant, planning to get pregnant or breastfeeding to avoid any harmful effects on the baby. There is not enough data available to know the exact effect of Pamidria 90mg Injection on the unborn baby or via breast milk. Also, women who are taking Pamidria 90mg Injection are advised to avoid pregnancy after 6 months of completing treatment with Pamidria 90mg Injection.. This is because traces of Pamidria 90mg Injection stays in the bones for long periods of time and may be released during this time which can cause harm to the baby.
