Manufacturer: Lupin Ltd
Salt Composition : Quetiapine(400mg)
Strip of 10 Tablet Xr
(Inclusive of all taxes)
Placidin 400mg Tablet XR may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience Neuroleptic malignant syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness or seizures.
Some common side effects of this medicine include decreased hemoglobin levels in the blood, increased triglycerides level in blood, decreased cholesterol level in blood, headache, extrapyramidal symptoms, dry mouth, and withdrawal symptoms. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it is better to rise slowly if you have been sitting or lying down. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may increase your weight but, modifying your lifestyle by having a healthy diet and exercising regularly can reduce this side effect.
You should be cautious while using this medicine as it may increase the risk of developing diabetes, so it is better to monitor glucose regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.
Placidin 400mg Tablet XR is an atypical antipsychotic. It works by modulating the action of certain chemical messengers in the brain that affect thoughts.
The primary route of elimination is through hepatic metabolism. In vitro studies show that quetiapine is predominantly metabolised by cytochrome P450 (CYP) 3A4. After administration of [14C]quetiapine, approximately 73% of the radioactivity was excreted in the urine and 21% in faeces.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Placidin
Dizziness
Dryness in mouth
Sleepiness
Constipation
Fatigue
High blood pressure
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Dyslipidemia
a condition with low thyroid hormone levels
diabetes
a high prolactin level
excessive fat in the blood
low amount of magnesium in the blood
dehydration
low amount of potassium in the blood
overweight
anemia
very low levels of granulocytes, a type of white blood cell
low levels of white blood cells
low levels of a type of white blood cell called neutrophils
confusion
suicidal thoughts
tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongue
neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion
a low seizure threshold
clouding of the lens of the eye called cataracts
high blood pressure
a heart attack
a low supply of oxygen rich blood to the heart
torsades de pointes, a type of abnormal heart rhythm
slow heartbeat
prolonged QT interval on EKG
chronic heart failure
inflammation of the middle tissue heart muscle
abnormal EKG with QT changes from birth
a disorder of the blood vessels of the brain
orthostatic hypotension, a form of low blood pressure
constipation
liver problems
seizures
weight gain
weakened patient
susceptible to breathing fluid into lungs
decreased blood volume
metabolic syndrome x
dementia in an elderly person
abnormal muscle movements
Placidin 400mg Tablet XR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Placidin 400mg Tablet XR.
Placidin 400mg Tablet XR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
Quetiapine is FDA approved for schizophrenia, acute manic episodes, and adjunctive treatment for major depressive disorder. Quetiapine is also used for several non-FDA-approved indications, such as generalized anxiety disorder.
QUETIAPINE may interact with medications, including antidepressants (citalopram, escitalopram, bupropion), opioid pain or cough relievers (codeine, hydrocodone), drugs for sleep or anxiety (alprazolam, lorazepam, zolpidem), muscle relaxants (carisoprodol, cyclobenzaprine), antihistamines (cetirizine, diphenhydramine) and analgesics (acetaminophen, hydrocodone, tramadol).
Do not chew, crush or break it. Placidin 400mg Tablet XR may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Placidin 400mg Tablet XR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Placidin 400mg Tablet XR for the treatment of schizophrenia and mania.
It is less likely to cause heart problems and movement disorders than other antipsychotics.
It may take 4 to 6 weeks to see treatment effects. Keep taking it as prescribed.
Use caution while driving or doing anything that requires concentration as Placidin 400mg Tablet XR can cause dizziness and sleepiness.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking it without talking to your doctor first as it may cause worsening of symptoms.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Placidin 400mg Tablet XR may be taken with or without food, but it is better to take it at a fixed time.
Q. What does Placidin 400mg Tablet XR do to the brain?
Placidin 400mg Tablet XR helps to correct chemical imbalances in the brain. It acts on various chemical messengers in the brain like dopamine and serotonin. It prevents the excessive activity of dopamine, helping to treat symptoms of schizophrenia and mania.
Q. Is Placidin 400mg Tablet XR a sleeping pill?
Placidin 400mg Tablet XR can make you feel sleepy, but it is not used as a sleeping pill. Placidin 400mg Tablet XR is approved for the treatment of symptoms of schizophrenia. It prevents as well as treats episodes of mania and depression in bipolar disorder. It is also used with other medicines to treat depression.
Q. How long does Placidin 400mg Tablet XR take to work?
You may start seeing an improvement within a week of starting Placidin 400mg Tablet XR but full benefits may take about 4-6 weeks to appear.
Q. Is Placidin 400mg Tablet XR good for anxiety?
Placidin 400mg Tablet XR has not been approved for the treatment of anxiety; however, your doctor may prescribe it for anxiety. Some studies suggest its use in post-traumatic stress disorder, generalized anxiety disorder, and anxiety associated with mood disorders.
Q. What should I avoid while taking Placidin 400mg Tablet XR?
Placidin 400mg Tablet XR can cause drowsiness. So, do not drive, operate machinery or do anything dangerous until you know how Placidin 400mg Tablet XR affects you. Do not drink alcohol while taking Placidin 400mg Tablet XR as it may worsen the drowsiness. Avoid getting dehydrated or over-exposure to heat.
Q. Can I stop taking Placidin 400mg Tablet XR if I am better now?
No, you should not stop taking Placidin 400mg Tablet XR without consulting your doctor. Suddenly stopping it may cause nausea, vomiting, headache, diarrhea, dizziness, irritability and inability to sleep. If you feel better, consult your doctor who will gradually reduce the dose before completely stopping it.
Q. Can Placidin 400mg Tablet XR cause weight gain?
Yes, weight gain is a common side effect of Placidin 400mg Tablet XR. If you feel you are gaining weight, consult your doctor or a nutritionist who will suggest you a diet and some exercise to help you manage your weight.
Q. How should Placidin 400mg Tablet XR be taken?
Take Placidin 400mg Tablet XR exactly as advised by your doctor. Do not split, chew or crush the tablets. Swallow the tablet whole with a glass of water. Do not take it with food. It is advised to take this medicine for at least one hour before a meal or at bedtime. Do not take grapefruit while taking Placidin 400mg Tablet XR as it may affect the working of this medicine.
