Manufacturer: Morepen Laboratories Ltd
Salt Composition : Pyrazinamide(750mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Pyriza 750mg Tablet is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification. Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.
The parent compound enters the bacterium passively and is metabolized via pyrazinamidase (PZase) within the cytoplasm to pyrazinoic acid; pyrazinoic acid is the active form of the drug
Pyrazinamide is used in the treatment of tuberculosis (TB) because its sterilizing effect against tubercle bacilli allows the shortening of treatment. It is part of standard treatment for drug-susceptible and drug-resistant TB, and it is being considered as a companion drug in novel regimens.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pyriza
Jaundice
Hepatitis (viral infection of liver)
Increased liver enzymes
Joint pain
diabetes.
a type of joint disorder due to excess uric acid in the blood called gout.
porphyria.
alcoholism.
severe liver disease.
Pyriza 750mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Caution is advised when consuming alcohol with Pyriza 750mg Tablet. Please consult your doctor.
Pyriza 750mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Gout.
Hepatotoxicity.
Liver disease.
Renal dysfunction.
Diabetes mellitus.
Hemodialysis.
Do not chew, crush or break it. Pyriza 750mg Tablet may be taken with or without food
Store below 30°C
If you miss a dose of Pyriza 750mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Pyriza 750mg Tablet along with other medications effectively treats tuberculosis.
Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Avoid drinking alcohol while taking Pyriza 750mg Tablet as this may increase the risk of side effects on the liver.
Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Pyriza 750mg Tablet as it may make hormonal contraceptives such as the pill less effective.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pyriza 750mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. What is Pyriza 750mg Tablet and what is it used for?
Pyriza 750mg Tablet is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is Pyriza 750mg Tablet bactericidal?
Pyriza 750mg Tablet is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Q. How does Pyriza 750mg Tablet work/treat tuberculosis?
Pyriza 750mg Tablet kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyriza 750mg Tablet is not known
Q. How does Pyriza 750mg Tablet cause hyperuricemia and gout?
Following oral intake of Pyriza 750mg Tablet, it gets converted in the body to pyrazinoic acid (active chemical form of Pyriza 750mg Tablet). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
