Manufacturer: La Renon Healthcare Pvt Ltd
Salt Composition : Sirolimus(1mg)
Raparen 1mg Injection is a prescription medicine that must be administered by a doctor or a nurse in a hospital or a clinical setting. You must receive the exact dose of it as per the prescription. An overdose of this medicine may have serious side effects on the body.
The common side effects of this medicine include headache, increased heart rate, high blood pressure, abdominal pain, nausea, diarrhea, constipation, rash, acne, joint pain, increased risk of infections, decreased blood cells, and decreased potassium level in blood. If any of the side effects persist or get worse, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions such as rash, shortness of breath, coughing, and swelling.
Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. If you notice signs of infection, any changes in the appearance or size of a mole, unusual growths or lumps, or unusual tiredness or weakness during the treatment, you must consult the doctor immediately.
Raparen 1mg Injection is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.
Sirolimus inhibits the activated mTOR pathway and proliferation of alveolar smooth muscle cell proliferation. In adult renal transplant patients with low- to moderate-immunologic risk, oral administration of 2 mg sirolimus led to a Cmax of 14.4 ± 5.3 ng/mL for oral solution and 15.0 ± 4.9 ng/mL for oral tablets.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Raparen
Decreased blood cells (red cells, white cells, and platelets)
Increased risk of infection
Nausea
Protein in urine
Upset stomach
Abdominal pain
Constipation
Decreased potassium level in blood
Diarrhea
Headache
High blood pressure
Increased heart rate
Rash
Joint pain
Acne
Hypersensitivity to drug/class/component, Lung transplant use, Liver transplant use. Caution if hepatic impairment, renal impairment, concurrent nephrotoxic agent use, delayed graft function, BMI >30 kg/m², hyperlipidemia.
Raparen 1mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Raparen 1mg Injection. Please consult your doctor.
Raparen 1mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
(sirolimus) is indicated for the prophylaxis of organ rejection in patients aged 13 years or older receiving renal transplants.
Drug-Drug Interactions: SIROLIMUS may interact with other immunosuppressive agents (e.g. mycophenolate mofetil, mycophenolic acid), antihistamines (e.g. loratadine), anti-hypertensive medicines (e.g. losartan), and diabetic medicines (e.g. insulin glargine, insulin aspart). The relevance of a particular drug interaction varies from person to person. Always consult your healthcare provider before starting or stopping any medication, and also inform your doctor of all your medical conditions and ongoing therapies before prescribing this medication. Considering these, your doctor may check the drug interactions before prescribing this medication.
Drug-Food Interactions: Avoid consumption of alcohol, eating grapefruit or drinking grapefruit juice while you are taking SIROLIMUS.
Drug-Disease Interactions: Brief your doctor if you have a medical history of allergic reactions to medicines, Infections, PML (progressive multifocal leukoencephalopathy), angioedema, hyperlipidemia, liver disease, liver transplantation, lung dysfunction, lung transplant, renal dysfunction before taking SIROLIMUS.
Drug-Drug Interactions Checker List:
MYCOPHENOLATE MOFETIL
MYCOPHENOLIC ACID
LORATADINE
LOSARTAN
INSULIN ASPART
INSULIN GLARGINE
Kindly do not self administer.
Store in a refrigerator (2 - 8°C). Do not freeze.
Consult a doctor before taking any medicines.
Consult a doctor before taking any medicines.
Raparen 1mg Injection is used with other medications to prevent organ transplant rejection.
Avoid certain vaccines during treatment as the vaccination may be less effective when taking Raparen 1mg Injection. Consult your doctor.
Use effective methods of contraception during the treatment and for 12 weeks after Raparen 1mg Injection has been stopped.
Limit the exposure to sunlight by covering your skin with clothing and using sunscreen with a high SPF because of the increased risk for skin cancer, when taking Raparen 1mg Injection.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
