Manufacturer: Ipca Laboratories Ltd
Salt Composition : Silodosin(8mg), Dutasteride(0.5mg)
Rapilif-D 8/0.5 Capsule Combipack is advised to take it in a dose and duration as per prescription. It should be taken with food, but take at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine.
Some common side effects of this medicine are retrograde ejaculation, dizziness, diarrhea, orthostatic hypotension, headache, nasopharyngitis, and nasal congestion. If any of the side effects persist or bother you, you must consult the doctor without delay.
Simple lifestyle changes can help you manage your symptoms better. Try to urinate as soon as you feel the urge, however, never strain or push to empty your bladder. You should avoid drinking caffeinated or alcoholic drinks at night and a few hours before going to bed or going out.
Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. If you have to undergo eye surgery due to cataracts or glaucoma then inform your eye doctor about the usage of this medicine. Patients with liver or kidney disease must be cautious while receiving the prescription, and they must receive regular follow-ups as per the doctor’s advice.
Rapilif-D 8/0.5 Capsule Combipack is an alpha blocker. It works by relaxing muscle around the bladder exit and prostate gland so urine is passed more easily.
Rapilif-D 8/0.5 Capsule Combipack is a 5-alpha reductase inhibitors. It blocks an enzyme which is necessary to change testosterone to another hormone that causes the prostate to grow. As a result, it helps to shrink the prostate and relieve the symptoms like difficulty in passing urine.
Silodosin also targets afferent nerves in the bladder, relieving bladder overactivity and storage symptoms. The absolute bioavailability is approximately 32%. Following oral administration of silodosin 8 mg once daily in healthy male subjects, Cmax was 61.6 ± 27.54 ng/mL and AUC was 373.4 ± 164.94 ng x hr/mL.
SIDE EFFECTS OF SILODOSIN
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Rapilif-D
Dizziness
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Headache
Ejaculation disorder
Nausea
Infection
Abdominal pain
SIDE EFFECTS OF DUTASTERIDE
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Rapilif-D
Impotence
Decreased libido
Ejaculation disorder
Breast enlargement in male
Breast tenderness in male
SILODOSIN+DUTASTERIDE should not be taken in patients with heart problems, low blood pressure, kidney or liver disease, have certain eye diseases, loss of vision due to loss of blood flow to the optic (eye) nerve.
Information regarding the use of Rapilif-D 8/0.5 Capsule Combipack during pregnancy is not available. Please consult your doctor.
Rapilif-D 8/0.5 Capsule Combipack may cause excessive drowsiness with alcohol.
Information regarding the use of Rapilif-D 8/0.5 Capsule Combipack during breastfeeding is not available. Please consult your doctor.
SILODOSIN+DUTASTERIDE may cause a sudden drop in your blood pressure which could lead to dizziness or fainting. Therefore, if SILODOSIN+DUTASTERIDE is taken along with blood pressure lowering medicines, it could lead to a severe decrease in blood pressure which could be lethal.
Drug-Drug Interaction: SILODOSIN+DUTASTERIDE interacts with medicines used to treat high blood pressure (prazosin, terazosin), drugs used to treat erectile dysfunction (sildenafil, tadalafil), azole antifungals (itraconazole, ketoconazole), HIV protease inhibitor (lopinavir, ritonavir).
Drug-Food Interaction: SILODOSIN+DUTASTERIDE may interact with grapefruit juice, alcohol, and tobacco. This may cause more side effects than it normally does. So, a SILODOSIN+DUTASTERIDE should not be taken along with them.
Drug-Disease Interaction: SILODOSIN+DUTASTERIDE should not be taken in patients with heart problems, low blood pressure, kidney or liver disease, have certain eye diseases, loss of vision due to loss of blood flow to the optic (eye) nerve.
Drug-Drug Interactions Checker List:
PRAZOSIN
TERAZOSIN
SILDENAFIL
TADALAFIL
ITRACONAZOLE
KETOCONAZOLE
LOPINAVIR
RITONAVIR
Store below 30°C
If you miss a dose of Rapilif-D 8/0.5 Capsule Combipack, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Silodosin
Silodosin helps in relieving the symptoms of enlarged prostate. It does not decrease the size of the prostate.
Silodosin must be taken with food.
You will feel better within hours or days of starting the treatment. Full effect is usually seen within 2 weeks.
Silodosin may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
If you are scheduled to undergo an eye surgery due to cataract or glaucoma, inform your eye doctor about the usage of Silodosin.
Inform your doctor if you have ever been diagnosed with kidney or liver problems.
Dutasteride
Your doctor has prescribed Dutasteride to shrink the enlarged prostate and reduce the risk of urinary retention.
It may take 3 to 6 months to see the full beneficial effect of Dutasteride. Hence, continue taking the medicine as advised by your doctor.
Dutasteride is usually well tolerated. However, it may produce some mild sexual side effects such as low sexual drive.
Do not donate blood for 6 months after taking the last dose of Dutasteride.
Benign prostatic hyperplasia
Q. What is Silodosin used for?
Silodosin is a medicine given for the treatment of difficulty in urination, urinary dribbling, a strong urge to urination, and frequent urination during the night. It is also used to relieve other symptoms associated with benign enlargement of the prostate gland. It works by reducing the tension in the muscles of the urinary tract like the prostate gland and urethra. It facilitates an easier flow of urine through the urethra, and hence, is very useful in men with difficulty of urination.
Q. When should I take Silodosin?
It is usually advised to take the dose of Silodosin daily with a meal. Prefer taking it at the same time of the day. In patients with any kidney impairment, the dose is reduced by the doctor. Patients who are unable to swallow the capsules can open the capsule and sprinkle the powder on a tablespoon of apple sauce. Consume this mixture immediately within 5 minutes without chewing and drink a glass of cool water immediately afterwards.
Q. Can I undergo cataract surgery while taking Silodosin?
In some cases, Silodosin has shown specific side effect on the eyes. It has been observed that during an eye surgery the iris tends to get floppy and pupil size becomes small in patients taking Silodosin. This makes the operation difficult and tedious. Hence, you should always inform your eye specialist about any history related to the use of Silodosin. Also, the doctor should be informed about all the medication that you are on before starting the treatment.
Q. Can Silodosin cause erectile dysfunction?
Silodosin usually does not affect erectile function. However, Silodosin may cause other sexual problems like ejaculatory dysfunction and failure to ejaculate. If you experience any side effects or uneasiness while taking this medication, contact your doctor immediately.
