Manufacturer: Lupin Ltd
Salt Composition : Reteplase(18mg)
Retefuse 18mg Injection is an injectable drug, given directly into a vein and it is given by a doctor as soon as possible after the first signs of a heart attack. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely. You may be given another medicine to stop blood clotting at the same time or after the treatment.
This medicine may increase your risk of bleeding, so it is better to be careful while shaving, cutting nails, or using sharp objects. Treatment with this drug can also cause nausea, vomiting, decreased blood pressure, and injection site bleeding.
This drug needs to be administered with care by an expert and is not suitable for everyone. There is a long list of situations where you will not be given Retefuse 18mg Injection including if you have had a head injury or surgery on your brain or spinal cord and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine.
Retefuse 18mg Injection is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.
Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Retefuse
Bleeding disorder
Nausea
Vomiting
Decreased blood pressure
Injection site bleeding
brain operation
operation on the spine
a brain tumor
retinal disease with hemorrhage in diabetic patient
increased risk of bleeding due to clotting disorder
injury of the brain and spinal cord
bleeding from the retina
puncture of artery that cannot have pressure exerted on it
puncture of vein that cannot have pressure exerted on it
significant uncontrolled high blood pressure
acute inflammation of the covering of the heart
subacute infection of heart valve
narrowing of mitral heart valve with atrial fibrillation
balloon-like swelling of an artery of the brain
a cholesterol embolism
blood clot in vein with a blood infection
bleeding
severe liver disease
severe bleeding of stomach or intestines in last 10 days
severe renal impairment
bleeding from the genitourinary system
malformed blood vessels
recent operation
major traumatic injury
mural thrombus of heart
internal bleeding
procedure to place indwelling epidural catheter
neuraxial anesthesia, local anesthesia injected in the epidural space or subarachnoid space
deep peripheral nerve block
deep plexus block
Retefuse 18mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Retefuse 18mg Injection. Please consult your doctor.
Retefuse 18mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Reteplase is a purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells.
Abciximab
Aspirin
Dipyridamole
Kindly do not self administer.
Store below 30°C
If you miss a dose of Retefuse 18mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
It should be given as soon as possible (within 12 hours) after the onset of a heart attack or within 4.5 hours of onset of stroke.
Let your doctor know immediately if you develop any nosebleeds, gum bleeding, black or tarry stools, or bruising.
Do not discontinue the medicines started after this injection as it may increase your chances of having another heart attack or stroke.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. How is Retefuse 18mg Injection administered?
Retefuse 18mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Retefuse 18mg Injection.
Q. Is Retefuse 18mg Injection safe?
Retefuse 18mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Q. Can the use of Retefuse 18mg Injection increase the risk of bleeding?
Yes, Retefuse 18mg Injection can increase the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.
Q. What medicines should I avoid while taking Retefuse 18mg Injection?
Retefuse 18mg Injection can interact with several medicines. If you are already taking Retefuse 18mg Injection, do not take any other medicine without talking to your doctor.
Q. When will I feel better after taking Retefuse 18mg Injection?
Retefuse 18mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not feel any difference after taking Retefuse 18mg Injection. This does not mean that the medicine is not working, therefore keep taking this medicine as prescribed.
