Manufacturer: Abbott
Salt Composition : Cefixime(200mg), Ofloxacin(200mg)
Safexim O Tablet is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.
Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Safexim O Tablet is a combination of two antibiotics: Cefixime and Ofloxacin. Cefixime works by preventing the formation of the bacterial protective covering which is essential for the survival of the bacteria in the human body. Ofloxacin works by preventing the bacteria from reproducing and repairing themselves. Together, they treat your infection effectively.
Gastrointestinal absorption is incomplete (about 40 to 50% is absorbed). The oral suspension is more rapidly and completely absorbed than the tablets. The elimination half-life is about 3 h (1). The drug is not appreciably metabolized, and 25 to 50% of the dose is excreted in the urine within 24 h.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Severe side effects of Safexim O
Insomnia (difficulty in sleeping)
Dizziness
Headache
Hypersensitivity
Hypereosinophilia
Agranulocytosis (deficiency of granulocytes in the blood)
Decreased white blood cell count (lymphocytes)
Decreased white blood cell count (neutrophils)
Granulocytopenia
Hemolytic anemia
Low blood platelets
Thrombocytosis
Gastrointestinal disturbance
Increased liver enzymes
Increased bilirubin in the blood
Increased blood urea
Pseudomembranous colitis
Jaundice
Acute renal failure
Breathlessness
Seizure
Inflammation of tendons
Tendon rupture
Serum sickness
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome
Itching
Rash
Drug fever
Joint pain
Erythema multiforme
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Paresthesia (tingling or pricking sensation)
Psychotic disorder
Visual disturbance
If you are allergic to cefixime or ofloxacin.
If you are allergic to cephalosporins or similar medicines.
If you are a pregnant woman or a breastfeeding mother.
If you have a history of fits or any other brain-related disorders.
If you have a family history of red blood cell disorder.
Safexim O Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Safexim O Tablet.
Safexim O Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Cefixime+Ofloxacin is used in adults for the treatment of typhoid fever and urinary tract infections.
CEFIXIME+OFLOXACIN should be avoided to be taken with vaccines including typhoid vaccine, cholera vaccine, and Bacillus Calmette Guerin (BCG vaccine), antiepileptic (carbamazepine), blood thinner (warfarin), antacid and ulcer treating medicine (aluminium hydroxide, magnesium hydroxide, cimetidine, sucralfate), medicine to treat excess uric acid (probenecid), medicines for arthritis (methotrexate), diuretics/water pills (furosemide), asthma medicine (theophylline) and pain killers (fenbufen, ibuprofen).
Do not chew, crush or break it. Safexim O Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Safexim O Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed Safexim O Tablet to cure your infection and improve your symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
Take it with food to avoid an upset stomach.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
Discontinue Safexim O Tablet and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Safexim O Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. Can I stop taking Safexim O Tablet when I feel better?
No, do not stop taking Safexim O Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.
Q. What if I miss my dose?
Take Safexim O Tablet as soon as you remember it. However, do not take it if it's almost time for your next dose. Also, do not take an extra dose to make up for your missed dose.
Q. Can the use of Safexim O Tablet cause diarrhea?
Yes, the use of Safexim O Tablet can cause diarrhea. It is an antibiotic which kills the harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, talk to your doctor about it.
Q. What if I don't get better after using Safexim O Tablet?
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.
