Manufacturer: Crescent Therapeutics Ltd
Salt Composition : Trimipramine(10mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Sizonorm Plus Tablet is a dibenzoxazepine antidepressant. It is used to treat depression. It also helps to enhance and brighten up the mood and is considered effective in treating depression that is unresponsive to other treatments.
Sizonorm Plus Tablet works by increasing the level of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms.
The most common side effects of this medicine include increased heart rate, blurred vision, dryness in the mouth, difficulty in urination, and constipation. Initially, this medicine may also cause a sudden drop in blood pressure, especially when you change positions. It may even cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. To lower the chance of dizziness, rise slowly if you have been sitting or lying down. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.
Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same or any other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine strictly as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should be avoided as alcohol interacts with this medicine to cause serious health issues.
Trimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.
Pharmacokinetics. The time to peak concentrations following a dose is 2 to 4 hours. The typical antidepressant therapeutic range of trimipramine concentrations is 150 to 300 ng/mL. The terminal half-life of trimipramine has been variously reported to be as little as 8 hours (in plasma) and as long as 24 hours
Increased heart rate
Weight gain
Dryness in mouth
Constipation
Difficulty in urination
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Blurred vision
overactive thyroid gland.
decreased blood platelets.
low levels of a type of white blood cell called neutrophils.
schizophrenia.
manic-depression.
suicidal thoughts.
alcoholism.
serotonin syndrome, a type of disorder with high serotonin levels.
Sizonorm Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Sizonorm Plus Tablet.
Sizonorm Plus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Trimipramine is a tricyclic antidepressant used to treat depression. Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties
Some products that may interact with this drug include: anticholinergics (such as atropine, belladonna alkaloids), clonidine, certain drugs for high blood pressure (such as guanadrel, guanethidine), drugs affecting liver enzymes that remove this medication from your body (including cimetidine, haloperidol
Swallow it as a whole. Do not chew, crush or break it. Sizonorm Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Sizonorm Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
It may take 4 to 6 weeks for Sizonorm Plus Tablet to start working. Keep taking it as prescribed.
It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Sizonorm Plus Tablet as it may cause excessive sleepiness.
Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sizonorm Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. What is Sizonorm Plus Tablet used for?
Sizonorm Plus Tablet belongs to a group of medicines known as antidepressants, used to treat depression. It works by restoring the chemical imbalance in the brain which helps to improve mood and behavior.
Q. Is Sizonorm Plus Tablet effective?
Yes, Sizonorm Plus Tablet is effective if taken in the dose and duration prescribed by the doctor. Avoid skipping doses and tell your doctor if you experience any side effects while taking Sizonorm Plus Tablet. The doctor may suggest ways to manage or prevent them. It may take a few weeks for you to see improvement in your symptoms. However, the treatment may be continued for a few months for effective management of your condition.
Q. What are the side effects of Sizonorm Plus Tablet?
Sizonorm Plus Tablet may cause side effects such as increased heart rate, blurred vision, dryness in mouth, difficulty in urination, weight gain, constipation and orthostatic hypotension (sudden lowering of blood pressure on standing). Consult your doctor if any of these side effects do not go away or worry you.
Q. Can I just stop taking Sizonorm Plus Tablet?
No, do not stop the medication abruptly even if you are feeling good as it may worsen your condition. Continue taking Sizonorm Plus Tablet for the duration prescribed by your doctor to get maximum benefit. Consult your doctor If the side effects bother you or if you have completed your course of treatment. The doctor will suggest gradual dose reduction before taking you off this medicine completely.
