Manufacturer: Dr Reddy's Laboratories Ltd
Salt Composition : Thalidomide(50mg)
Multiple Myeloma is a certain type of cancer which affects a specific white blood cell called plasma cell.
Before starting the treatment with THAANGIO 50MG CAPSULE, your doctor might want you to take some diagnostic tests to understand your existing condition.
Before taking THAANGIO 50MG CAPSULE, inform your doctor if you have or had liver, heart or kidney disease, high blood pressure, high cholesterol, blood clot, nerve damage, fall in number of white blood cells with fever and infection, severe skin infections, viral infections, or prone to bleeding and bruising.
THAANGIO 50MG CAPSULE is not recommended for use in pregnant and breast-feeding women. Consult with your doctor before taking it.
It should be used with caution in men as it passes through the semen. Men must not donate semen while getting treated with THAANGIO 50MG CAPSULE and should use effective contraception. THAANGIO 50MG CAPSULE should not be taken by children and adolescents below 18 years of age.
The most common side effects of taking THAANGIO 50MG CAPSULE are constipation, dizziness, sleepiness, tiredness, shaking, abnormal sensations, swelling of hands and feet. Ask for your doctor’s advice if any of these worsen or doesn’t improve.
THAANGIO 50MG CAPSULE effectively helps in the treatment of multiple myeloma by helping the body’s immune system and inhibiting the production of a certain type of protein (Interleukin-6) which is responsible for the growth of cancer cells. THAANGIO 50MG CAPSULE also stops the development of blood vessels in the cancer cells and stimulates the immune system to kill the cancer cells.
Due to its low aqueous solubility and thus low dissolution is the gastrointestinal tract, thalidomide's absorption is slow, with a tlag of 20-40 min. Therefore, thalidomide exhibits absorption rate-limited pharmacokinetics or "flip-flop" phenomenon.
COMMON
Constipation
Feeling dizzy, sleepiness, feeling tired
Shaking (tremor)
Decreased or abnormal sensation (dysesthesia)
Swelling of hands and feet
Indigestion
Nausea, vomiting
Dry mouth
Rash, dryness of the skin
Feeling weak, faint or unsteady
Lack of energy or strength
Low blood pressure
Fever, feeling generally unwell
Convulsions
A spinning feeling in the head which causes difficulty in standing up and moving normally
Blurred vision
Chest infection, lung disease (chest pain while coughing or breathing, difficulty in breathing)
Slow heart rate, heart failure
Depression, confusion, mood changes, anxiety
Hearing decreased or deafness
UNCOMMON
Inflammation and swelling of the tubes in the lungs (bronchitis)
Inflammation of the cells lining the stomach wall (pain in the abdomen, feeling of fullness)
Hole in the part of the large bowel (colon) which can cause infection
Bowel obstruction
Fall of blood pressure on standing that may cause fainting
Heart block or atrial fibrillation (irregular heartbeat)
RARE
Stop taking THAANGIO 50MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Signs of progressive multifocal leukoencephalopathy (PML) (blurred, loss of or double vision, weakness in an arm or a leg, difficulty speaking, changes in walking or problems with balance, decreased sensation or loss of sensation, persistent numbness, memory loss or confusion)
Extremely intense and serious skin reactions appearing as rashes with or without blisters. Skin irritation, sores or swelling in the mouth, throat, eyes, nose and around the genitals, oedema, flu-like symptoms and fever
Allergic reactions which may include localised or generalised pruritic rash, angioedema and anaphylactic reaction and appear as hives, rashes, swelling of eyes, mouth or face, the difficulty of breathing or itching
Peripheral neuropathy (tingling, numbness, abnormal coordination or pain in hands and feet)
Signs of pulmonary embolism, blood clot in lungs (sudden pain in chest or difficulty in breathing)
Signs of blood clots in veins of the legs (pain or swelling in legs, especially in lower leg or calves)
Signs of heart attack (chest pain spreading to the arms, neck, jaw, back or stomach, sweating, breathless, nausea, vomiting)
Signs of stroke (temporary difficulty in seeing or speaking)
Signs of infections (fever, sore throat, chills, cough, mouth ulcers)
Bleeding or bruising without any injury
Allergic to any ingredient in thalidomide; Sodium oxybate (GHB). Pregnant, planning to become pregnant, or become pregnant during treatment with thalidomide. Not using at least 2 forms of effective birth control or are not avoiding sexual contact with men.
THAANGIO 50MG CAPSULE is not recommended for use in pregnant women as it may increase the chances of serious birth defects in the baby such as shortened arms or legs, eye or ear defects, improperly formed hands or feet and problems with internal organs. Your doctor might ask you to take pregnancy tests regularly while getting treated with THAANGIO 50MG CAPSULE and even after the treatment stops. Consult your doctor before taking THAANGIO 50MG CAPSULE.
Avoid the consumption of alcohol while taking THAANGIO 50MG CAPSULE as it can make you sleepier.
THAANGIO 50MG CAPSULE is not recommended for use in breastfeeding women as it is not known if it passes through the breast milk. Consult your doctor before taking THAANGIO 50MG CAPSULE.
Thalidomide is a medication used to manage and treat advanced leprosy and multiple myeloma, and various other solid and hematologic malignancies. It is in the immunomodulatory class of medications.
Drug-Drug Interactions: THALIDOMIDE may interact with digitalis glycosides (digoxin), blood thinner (warfarin), bisphosphonate (pamidronate), anti-depressant (duloxetine), antipsychotics (aripiprazole, prochlorperazine), antibiotic (levofloxacin), pain killer (tramadol), anti-neoplastic agent (bortezomib), antiemetic (ondansetron), barbiturates (pentobarbital, phenobarbital, secobarbital), antihistamines, anxiolytics, hypnotics, opiate derivatives, anticholinesterases, herbal supplement used to treat depression (St. John’s wort) and beta-blockers.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have seizures, HIV infection, hypotension, neuropathy, or neutropenia (low levels of neutrophils).
Drug-Drug Interactions Checker List:
DIGOXIN
WARFARIN
DULOXETINE
ARIPIPRAZOLE
PROCHLORPERAZINE
LEVOFLOXACIN
TRAMADOL
BORTEZOMIB
ONDANSETRON
PHENOBARBITAL
SECOBARBITAL
THAANGIO 50MG CAPSULE for you depending on your age, disease condition and body weight.
Keep THAANGIO 50MG CAPSULE out of reach of children
Store at room temperature
If you miss a dose, please consult your doctor.
If you or anyone else accidentally take too much of THAANGIO 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage of THAANGIO 50MG CAPSULE are numbness and tingling in hands or feet, excessive sleepiness, constipation, dry mouth, skin rash and weakness.
Use in paediatrics:
THAANGIO 50MG CAPSULE is not recommended for use in children and adolescents (aged below 18 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
Your doctor will advise the correct dose and duration of THAANGIO 50MG CAPSULE for you depending on your age, disease condition and body weight.
What is THAANGIO 50MG CAPSULE and why is it given?
THAANGIO 50MG CAPSULE contains Thalidomide which belongs to the group of medicines called Immunomodulating Agents. It is used with other medicines in the treatment of a type of cancer called Multiple Myeloma in patients below 65 years of age and have not been prescribed any other medicine and in patients above 65 years of age who cannot tolerate high doses of chemotherapy.
Can I donate blood while taking THAANGIO 50MG CAPSULE?
No, you must not donate blood while getting treated with THAANGIO 50MG CAPSULE and for at least 7 days after stopping the treatment. This is because THAANGIO 50MG CAPSULE has dose-dependent effects and can cause serious birth defects in babies or even foetal death. Consult your doctor before donating.
How to manage if I forget to take a dose of THAANGIO 50MG CAPSULE?
If you forget to take a dose of THAANGIO 50MG CAPSULE at your regular time and less than 12 hours have passed, then take THAANGIO 50MG CAPSULE immediately. If it has been more than 12 hours, do not take the missed dose, take your next dose at the same time of the day.
