Manufacturer: Ajanta Pharma Ltd
Salt Composition : Tolvaptan(30mg)
TOFANTA prevents the vasopressin having effect on the water retention. This reduces the amount of water in the body which slows the growth of kidney cysts in patients with ADPKD, reduces symptoms of the disease and increases urine production. It also increases the sodium and salt levels in your blood by removing extra water content in the body as urine in patients with heart failure, liver disease, and certain hormone imbalances.
Tofanta Tablet works by blocking the action of vasopressin hormone which is also known as an antidiuretic hormone in the kidney. This results in failure of water absorption by the kidney leading to an increase in urine production, decreasing water content in the blood and thereby increasing sodium level in the blood.
The pharmacokinetics and pharmacodynamics of tolvaptan have been evaluated in multiple trials in healthy subjects. Dose-proportional increases in exposure to tolvaptan, as measured by area under the curve to infinity (AUC∞) and maximum plasma concentration (Cmax), were observed for doses of 15–60 mg.
Headache
Dizziness
Excessive thirst
Loose motions
Dry mouth
Increased frequency of urination
Excessive urination at night
Tiredness
Dehydration
Sleeplessness
Tolvaptan is contraindicated with the use of a strong CYP 3A inhibitor due to drug interaction. It is also contraindicated in hypovolemic hyponatremia because it might precipitate hypotension and renal failure. It should not be administered in anuric patients due to expected lack of clinical benefit.
TOFANTA is not recommended for use in pregnant women unless necessary. Consult your doctor for advice.
Avoid drinking too much of alcohol while taking this medicine.
TOFANTA is not recommended for use in breastfeeding women unless necessary. Consult your doctor for advice.
Use with caution
Below 9years: Contraindicated
Tolvaptan is used to treat hyponatremia (low sodium in the blood) in patients with heart failure or syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan is also used to slow kidney function decline in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).
TOLVAPTAN may have interaction with antibiotic (clarithromycin, telithromycin, sulfamethoxazole, trimethoprim), anti-fungal (ketoconazole, itraconazole), anti-HIV (ritonavir, indinavir, nelfinavir, saquinavir), antidepressant (nefazodone), aldosterone receptor antagonist (spironolactone), angiotensin receptor inhibitor (valsartan, sacubitril), blood thinner (heparin).
Do not chew, crush or break it. Tofanta 30mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Tofanta 30mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tofanta 30mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
What is TOFANTA used to treat?
It is used to treat low levels of salt (sodium) in the blood, which can result from conditions such as heart failure and certain hormone imbalances.
Can TOFANTA be used in pregnant women?
No. It is not recommended for use in the pregnant women. Consult your doctor before taking.
What causes low sodium?
A low sodium level has many causes, including consumption of too many fluids, kidney failure, heart failure, cirrhosis, and use of diuretics. Symptoms result from brain dysfunction.
