Manufacturer: Glenmark Pharmaceuticals Ltd
Salt Composition : Tolvaptan(30mg)
Tolvasca works by blocking the action of vasopressin hormone which is also known as an antidiuretic hormone on the kidney. This results in failure of water absorption by the kidney leading to an increase in urine production, decreasing water content in the blood and thereby increasing sodium level in the blood. Headache, dizziness, excessive thirst, loose motions, dry mouth, etc. are some of the side effects of using this medicine. This medicine can be taken with or without food.
Tolvasca Tablet works by blocking the action of vasopressin hormone which is also known as an antidiuretic hormone in the kidney. This results in failure of water absorption by the kidney leading to an increase in urine production, decreasing water content in the blood and thereby increasing sodium level in the blood.
The pharmacokinetics and pharmacodynamics of tolvaptan have been evaluated in multiple trials in healthy subjects. Dose-proportional increases in exposure to tolvaptan, as measured by area under the curve to infinity (AUC∞) and maximum plasma concentration (Cmax), were observed for doses of 15–60 mg.
Headache
Dizziness
Excessive thirst
Loose motions
Dry mouth
Increased frequency of urination
Excessive urination at night
Tiredness
Dehydration
Sleeplessness
Tolvaptan is contraindicated with the use of a strong CYP 3A inhibitor due to drug interaction. It is also contraindicated in hypovolemic hyponatremia because it might precipitate hypotension and renal failure. It should not be administered in anuric patients due to expected lack of clinical benefit.
Tolvasca 30 mg Tablet is not recommended for use during pregnancy as it may harm your developing foetus. Consult your doctor if you are pregnant.
Caution is advised when consuming alcohol with Tolvasca 30 Tablet. Please consult your doctor.
Tolvasca 30 mg Tablet is not recommended for use while breastfeeding. Consult your doctor if you are breastfeeding.
Use with caution
Below 9years: Contraindicated
Tolvaptan is used to treat hyponatremia (low sodium in the blood) in patients with heart failure or syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan is also used to slow kidney function decline in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).
TOLVAPTAN may have interaction with antibiotic (clarithromycin, telithromycin, sulfamethoxazole, trimethoprim), anti-fungal (ketoconazole, itraconazole), anti-HIV (ritonavir, indinavir, nelfinavir, saquinavir), antidepressant (nefazodone), aldosterone receptor antagonist (spironolactone), angiotensin receptor inhibitor (valsartan, sacubitril), blood thinner (heparin).
Do not chew, crush or break it. Tolvasca 30 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Tolvasca 30 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Tolvasca 30 Tablet treats low sodium levels in the blood.
It also improves urine flow without causing the body to lose too much sodium as you urinate.
Take it at the same time everyday. Take it according to the dose and duration prescribed by your doctor.
To avoid dehydration, it is best to drink something as soon as you feel thirsty, but avoid alcoholic drinks.
Do not take Tolvasca 30 Tablet if you are unable to urinate, if you are unable to tell when you are thirsty, or if you are severely dehydrated.
You will need to be in a hospital under observation any time you start or restart treatment with Tolvasca 30 Tablet.
Inform your doctor if you notice problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, or mood changes.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tolvasca 30 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. What is the most important information I need to be aware of while taking Tolvasca 30 Tablet?
Tolvasca 30 Tablet may cause the level of sodium in your blood to increase too quickly. This quick increase in sodium levels [osmotic demyelination syndrome (ODS)] may cause serious nerve damage, which can further cause coma and even death.The symptoms of ODS could be trouble in speaking, trouble in swallowing or a feeling of food or liquid getting stuck while swallowing, drowsiness, confusion, mood changes, fits, trouble controlling body movement (involuntary movement) and weakness in muscles of the arms and legs.
Q. For how long do I need to take Tolvasca 30 Tablet?
Tolvasca 30 Tablet is used for correction of sodium levels in blood. Though the dose and duration are prescribed by the doctor, Tolvasca 30 Tablet should not be taken for more than 30 days. Once the sodium levels return to normal, it can be stopped after talking to the doctor.
Q. Does Tolvasca 30 Tablet affect the sugar levels in blood?
Yes, Tolvasca 30 Tablet may increase the blood sugar levels. Therefore, patients with diabetes mellitus need to be extra careful while taking Tolvasca 30 Tablet and should keep a check on blood sugar levels regularly.
Q. Who should not take Tolvasca 30 Tablet?
You should not take Tolvasca 30 Tablet if you have low sodium levels, cannot replace fluids by drinking or if you cannot tell when you are thirsty, dizzy or feeling faint or if your kidneys are not working properly because of excessive loss of fluids. You should also avoid Tolvasca 30 Tablet if your body is not able to make urine, you are allergic to Tolvasca 30 Tablet or if you are on certain medicines which interfere with the working of Tolvasca 30 Tablet.
Q. Can I have grapefruit juice while taking Tolvasca 30 Tablet?
No, you should not take grapefruit or grapefruit juice while on Tolvasca 30 Tablet. The reason being, grapefruit or grapefruit juice may increase the levels of Tolvasca 30 Tablet in your blood and your sodium levels may rise too quickly.
Q. What will happen if I take excess of Tolvasca 30 Tablet?
You may need urgent medical attention. Call your doctor or seek emergency service at a nearby hospital. Symptoms of taking too much Tolvaptan may include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, very low blood pressure, passing more urine than normal and fainting.
