Manufacturer: Sun Pharmaceutical Industries Ltd
Salt Composition : Tramadol(50mg)
Tranzex 50mg Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms.The most common side effects of this medicine include nausea, constipation, dry mouth, sleepiness, dizziness, and vomiting. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.Before using it, you should let your doctor know if you have problems with your heart, liver, or kidneys. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.
TRANZEX 50MG INJECTION contains Tramadol that works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby, inhibits the transmission of pain signals from nerves to brain.
Tramadol is extensively metabolized in the liver by O- and N-desmethylation and by conjugation reactions to form glucuronides and sulfate metabolites. The O-desmethylation of tramadol to its main active metabolite, O-desmethyltramadol (M1), is catalyzed by cytochrome P450 (CYP) 2D6 [19,20,32] (Fig.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tranzex
Nausea
Constipation
Sleepiness
Dizziness
Vomiting
low blood sugar
decreased function of the adrenal gland
low amount of sodium in the blood
symptoms from alcohol withdrawal
suicidal behavior
suicidal thoughts
alcoholism
alcohol intoxication
drug abuse
depression
serotonin syndrome, a type of disorder with high serotonin levels
a low seizure threshold
asthma
decreased lung function
blockage of the stomach or intestine
hardening of the liver
seizures
opioid overdose
a patient who is producing milk and breastfeeding
benzodiazepine overdose
high pressure within the skull
nervous system infection of brain and spinal cord
inherited dysfunction of autonomic nerve function
chronic obstructive pulmonary disease
CYP2D6 ultrarapid metabolizer
CYP2D6 poor metabolizer
sleep apnea due to airway obstruction
surgical removal of the adenoids in pediatric patient
surgical removal of the tonsils in pediatric patient
chronic kidney disease stage 4 (severe)
chronic kidney disease stage 5 (failure)
chronic kidney disease stage 5 (failure) without dialysis GFR<15 mL/min
Tranzex 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Tranzex 50mg Injection.
Tranzex 50mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness.
Use with caution
Below 9years: Contraindicated
It has specific indications for moderate to severe pain. It is considered a class IV drug by the FDA and has been since July 7th, 2014. Due to possible abuse and addiction potential, limitations to its use should be for pain that is refractive to other pain medication, such as non-opioid pain medication.
TRAMADOL may have interaction with pain killers (pentazocine, buprenorphine, nalbuphine), blood thinners (warfarin), anti-anxiety drugs (alprazolam), fits related medicines (carbamazepine), medicines used to prevent nausea (ondansetron), antifungal drugs (ketoconazole), antibiotic (ciprofloxacin, erythromycin), anticancer drugs (ceritinib, lapatinib), immunosuppressants (fingolimod), antidepressants (fluoxetine, doxepin), antipsychotics (droperidol), and HIV/AIDS drugs (saquinavir).
Kindly do not self administer.
Store below 30°C
If you miss a dose of Tranzex 50mg Injection, consult your doctor.
Consult a doctor before taking any medicines.
Use only for severe acute pain for not more than 5 days.
Prolonged use may result in physical and psychological dependence even at recommended dosages.
Avoid driving or using machinery if you feel dizzy after taking Tranzex 50mg Injection.
It is better to take with food to avoid an upset stomach.
Your doctor may adjust your dose if you have liver or kidney disease.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is there anything I need to be careful about while on therapy with Tranzex 50mg Injection?
Tranzex 50mg Injection may cause drowsiness and dizziness, especially in the beginning of the treatment. Do not drive or work with tools or machinery if your alertness is affected. It is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.
