Manufacturer: Glaxo SmithKline Pharmaceuticals Ltd
Salt Composition : Lapatinib(250mg)
Tykerb 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea, or vomiting. Your doctor may check your liver function before, during, and after treatment with this medicine.
Before taking Tykerb 250mg Tablet, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Tykerb 250mg Tablet is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.
Pharmacokinetic data from these studies indicated that serum lapatinib concentrations peak 4 hours after dosing, increase with increasing dose, accumulate approximately two-fold with daily dosing, and achieve steady state in 6 to 7 days, suggesting an effective half-life of 24 hours.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tykerb
Abdominal pain
Back pain
Breathing problems
Constipation
Cough
Diarrhea
Fatigue
Headache
Hot flashes
Increased bilirubin in the blood
Insomnia (difficulty in sleeping)
Joint pain
Liver damage
Loss of appetite
Mucosal inflammation
Nausea
Pain in extremities
Rash
Stomatitis (Inflammation of the mouth)
Vomiting
Weakness
Weight gain
contraindicated in patients with known severe hypersensitivity (e.g., 83 anaphylaxis) to this product or any of its components.
Tykerb 250mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Tykerb 250mg Tablet. Please consult your doctor.
Tykerb 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
indicated in combination with: • capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress human epidermal growth factor receptor 2 (HER2) and who have received prior therapy, including an anthracycline, a taxane, and trastuzumab.
Drug-Drug Interactions: LAPATINIB may interact with CYP3A4 inhibitors (clarithromycin, erythromycin, itraconazole, ketoconazole, ritonavir, verapamil, diltiazem), CYP3A4 inducers (phenytoin, phenobarbitone, carbamazepine, rifampicin, st. john's wort), antiviral drugs (indinavir, efavirenz, atazanavir), etc.
Drug-Food Interactions: Avoid smoking and alcohol consumption.
Drug-Disease Interactions: Inform your doctor if you have cardiac problems, lung disease, or liver/kidney disease.
Drug-Drug Interactions Checker List:
CLARITHROMYCIN
ERYTHROMYCIN
KETOCONAZOLE
RITONAVIR
VERAMAPIL
DILTIAZEM
PHENYTOIN
PHENOBARBITAL
CARBAMAZEPINE
ST JOHN'S WORT
INDINAVIR
EFAVIRENZ
ITRACONAZOLE
Do not chew, crush or break it. Tykerb 250mg Tablet is to be taken empty stomach.
Store below 30°C
If you miss a dose of Tykerb 250mg Tablet, consult your doctor.
Consult a doctor before taking any medicines.
It should be taken 1 hour before or 2 hours after the meal, preferably at the same time every day.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tykerb 250mg Tablet is to be taken empty stomach.
Q. Is Tykerb 250mg Tablet a chemotherapy medicine?
No, this is a targeted drug that belongs to a class of anti-cancer medicines. They are more specific than chemotherapy in their mechanisms of action. Tykerb 250mg Tablet belongs to the tyrosine kinase inhibitors group of medicines. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
Q. Can Tykerb 250mg Tablet be given in combination with other anti-cancer drug?
Yes, Tykerb 250mg Tablet can be used with other anti-cancer drugs. Generally, it is used in combination with capecitabine to treat advanced breast cancer in patients who have already been treated with chemotherapy. Tykerb 250mg Tablet is also used with letrozole to treat breast cancer in post-menopausal women.
Q. How should I take Tykerb 250mg Tablet?
You should take Tykerb 250mg Tablet exactly as advised by your doctor. Swallow Tykerb 250mg Tablet tablets whole with a glass of water, at the same time each day. You must take Tykerb 250mg Tablet 1 hour before or 1 hour after meals and at the same time concerning food each day (e.g., you could always take your tablet one hour before breakfast).
Q. Does Tykerb 250mg Tablet have any effect on liver?
Tykerb 250mg Tablet may cause liver damage which can be severe or life-threatening. Liver damage can occur as soon as several days or as late as several months after the start of treatment with Tykerb 250mg Tablet. Inform your doctor if you have or had liver disease. If you experience any of the symptoms such as itching, change in color of the skin or eyes (yellowing), discoloration of urine, pain in the upper right part of the stomach, unusual bleeding or bruising, or pale or dark stools, call your doctor immediately.
