Manufacturer: Abbott
Salt Composition : Ursodeoxycholic Acid(450mg)
Udiliv 450mg Tablet should be swallowed whole after a meal and with a glass of milk or water. The dose will depend on what you are being treated for and your body weight. Take it regularly to get maximum benefit and keep taking it for as long as prescribed (several months or longer). Keep taking it even if your symptoms disappear.
Multiple mechanisms of action of UDCA have been described aiming at one or more of the pathogenetic processes of cholestatic liver diseases: protection of injured cholangiocytes against toxic effects of bile acids, stimulation of impaired biliary secretion, stimulation of detoxification of hydrophobic bile
Ursodeoxycholic acid is absorbed incompletely because of its low aqueous solubility. After absorption, it is conjugated with glycine or taurine and circulates with the endogenous bile acids. At usual doses (8-10 mg/kg/day), the pool of ursodeoxycholyl conjugates constitutes 30-60% of circulating bile acids
Abdominal pain
Diarrhea
Hair loss
Itching
Nausea
Rash
Ursodeoxycholic acid, ursodiol is contraindicated for use in patients hypersensitive to ursodiol, the formulation, or with other bile acid agents hypersensitivity. Ursodiol is contraindicated in patients with complete biliary obstruction
Udiliv 450mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Udiliv 450mg Tablet may cause excessive drowsiness with alcohol.
Udiliv 450mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Ursodeoxycholic acid is indicated in the treatment of primary biliary cirrhosis (PBC) and for the dissolution of radiolucent gallstones in patients with a functioning gall bladder. Hepatobiliary disorders associated with cystic fibrosis in children aged 6 to 18 years.
The absorption of ursodeoxycholic acid was impaired by colestyramine, colestimide, colestipol, aluminium hydroxide and smectite. Metabolic drug interactions were reported for the cytochrome P4503A substrates, ciclosporin, nitrendipine and dapsone. Conclusions: Ursodeoxycholic acid is generally well tolerated
Do not chew, crush or break it. Udiliv 450mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Udiliv 450mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
Consult a doctor before taking any medicines
Udiliv 450mg Tablet should be taken after a meal with a glass of milk or water.
Eat a healthy diet, exercise regularly, and avoid alcohol intake.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy, and every 6 months thereafter.
Do not stop taking the medication without talking to your doctor.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Udiliv 450mg Tablet is to be taken with food.
Q. When should I take Udiliv 450mg Tablet?
The suitable timing of taking this medicine might differ depending upon your condition. Your doctor might instruct you to take 2 to 3 doses per day and suggest to take the last dose at bedtime. Udiliv 450mg Tablet should be taken with water milk and can be taken with food or after food. When prescribed for dissolving gallstones, it is usually suggested to be taken once daily at night. Ideally, it should be taken at a gap of 6 hours, for example at 8 am, 2 pm and 8 pm.
Q. Is Udiliv 450mg Tablet safe?
Udiliv 450mg Tablet is usually considered to be a safe and effective medicine. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs, your doctor may reduce the dose and if it persists, your treatment may be discontinued. Additionally, using this medicine as a long-term therapy may also affect your liver enzyme levels. To keep a check on this, your doctor will keep monitoring your liver enzyme levels regularly. Despite these minor side effects, this medicine is supposed to be a good alternative to surgery in some patients with gallstones.
Q. How does Udiliv 450mg Tablet help the liver?
Udiliv 450mg Tablet acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile. This medicine also acts by stopping the intestines from absorbing the bile salts and cholesterol. So, the reduced cholesterol saturation in the bile from the liver leads to the gradual dissolving of cholesterol from gallstones, leading to a decrease in size and their eventual dissolution. It also reduces elevated liver enzyme levels by increasing the bile flow through the liver, hence protecting the liver cells.
Q. Does Udiliv 450mg Tablet cause weight gain?
Yes, there is a chance of weight gain with Udiliv 450mg Tablet, but it is not common. The use of Udiliv 450mg Tablet can cause weight gain when prescribed in patients with liver disease associated with chronic stasis of bile in small bile ducts of the liver. In such condition, bile cannot flow from the liver to the small intestine. Again, the chance of weight gain varies from person to person depending upon the disease, so consult your doctor if you experience weight gain.
Q. What should I avoid while taking Udiliv 450mg Tablet?
While taking Udiliv 450mg Tablet, avoid taking an antacid preparation without consulting your doctor, as they decrease the effectiveness of Udiliv 450mg Tablet. You should also avoid medicines like cholestyramine or colestipol as they affect the effectiveness of Udiliv 450mg Tablet. So, ask your doctor about the time gap that should be maintained between Udiliv 450mg Tablet and these medicines. Also, avoid taking oral contraceptives, estrogenic hormones and blood cholesterol-lowering agents such as clofibrate as they may increase the chances of developing gallstones and act opposite to the Udiliv 450mg Tablet.
