This medicine acts by blocking the effect of progesterone and helping in termination of pregnancy. It also blocks the cortisol receptors and helps in controlling high blood sugar levels in people with Cushing's syndrome.
The pharmacokinetics of mifepristone are characterised by rapid absorption, a long half-life of 25 to 30 hours and micromolar serum concentrations following ingestion of doses currently in clinical use.
Major & minor side effects for Unwanted 200 MG Tablet
Heavy vaginal bleeding
Infections
Unusual tiredness and weakness
Abdominal pain and cramps
Uterine cramping
Nausea and Vomiting
Headache
Dizziness
Diarrhea
Pain in the arms and legs
Decreased appetite
Sleeplessness
Difficult or painful urination
Loss of strength
Difficult and painful breathing
Mifepristone is contraindicated in patients with: an ectopic pregnancy, hypersensitivity to prostaglandins, undiagnosed renal masses, concurrent IUD use, hemorrhagic disorders, and severe anemia.
The use of this medicine is acceptable for medical termination of intrauterine pregnancy which is 63-70 days old. However, use of this medicine for control of elevated blood sugar levels along with elevated cortisol level is not recommended for pregnant women. It should be noted that a failed attempt to terminate pregnancy might result in severe complications.
The use of this medicine should be avoided by women who are breastfeeding. However, if it becomes necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor regarding the potential benefits and risks involved before taking this medicine.
Mifepristone is a synthetic steroid. It is a medication most commonly used for medically induced abortions. Mifepristone can also be used in the management and treatment of Cushing's syndrome and uterine leiomyomas. At low doses, mifepristone blocks progesterone by competitively binding its intracellular receptor.
Drug-Drug Interactions: MIFEPRISTONE interacts with corticosteroids (dexamethasone), antifungal (ketoconazole, itraconazole), antibiotics (erythromycin, rifampicin), anti-epileptic (phenytoin, phenobarbital, carbamazepine), immunosuppressants (cyclosporine, tacrolimus, sirolimus), medicines to treat migraine (ergotamine). So, MIFEPRISTONE should not be taken along with these drugs.
Drug-Food Interactions: Please tell your doctor about all the Vitamins, herbs, and supplements you are taking as the MIFEPRISTONE may interact with them to produce unpleasant side effects. Also, MIFEPRISTONE is known to interact with St John’s Wort (a natural remedy used to treat mild depression) and grapefruit juice.
Drug-Disease Interactions: MIFEPRISTONE should be taken with caution in people with a bleeding problem, confirmed or suspected ectopic pregnancy, heart problem, liver or kidney disease, or vaginal bleeding.
Drug-Drug Interactions Checker List:
DEXAMETHASONE
KETOCONAZOLE
ITRACONAZOLE
ERYTHROMYCIN
RIFAMPICIN
PHENYTOIN
PHENOBARBITAL
CARBAMAZEPINE
CYCLOSPORINE
TACROLIMUS
SIROLIMUS
ERGOTAMINE
Take the missed dose as soon as you remember if the intended use is to control elevated blood sugar levels. If it is almost time for the next scheduled dose then the missed dose should be skipped. For medical termination of pregnancy, it is a single dose therapy and hence missing a dose is not possible.
Contact your doctor and seek immediate help if an overdose with mifepristone is suspected.
Termination of pregnancy
Cushing's syndrome
How long does it take for this medicine to take effect?
This medicine is rapidly absorbed into the bloodstream upon oral administration and reaches the peak levels within 1-2 hours.
How long do the effects of this medicine last?
The effect of this medicine lasts for an average duration of 7-10 days.
Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
