Manufacturer: Intas Pharmaceuticals Ltd
Salt Composition : Valganciclovir(450mg)
Valgacel 450mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina (retinitis) in adult patients with acquired immunodeficiency syndrome (AIDS). It is also used for the prevention of CMV infection in patients who have received an organ transplant from a CMV-infected donor.
Valgacel 450mg Tablet should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. It should be taken with food. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. You should drink plenty of water while on treatment with this medicine as it helps to prevent dehydration and kidney damage.
It may lead to a few common side effects like fever, diarrhea, vomiting, anemia, low white blood cell, and low platelet level. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.
Mechanism of action: Valganciclovir is the prodrug of ganciclovir with improved bioavailability. Ganciclovir is a synthetic analogue of 2-deoxyguanosine. Once phosphorylated, ganciclovir triphosphate inhibits viral DNA synthesis
Systemic exposure to valganciclovir was low [with an area under the concentration-time curve to 24 hours (AUC24) of 1.3 to 2.5% that of ganciclovir]. The mean plasma concentrations of ganciclovir were dose-related. Peak concentrations of ganciclovir were achieved approximately 30 minutes after those for valganciclovir
Diarrhea
Fever
Vomiting
Anemia (low number of red blood cells)
Decreased white blood cell count
Low blood platelets
dehydration.
significantly decreased activity of the bone marrow.
low blood counts due to bone marrow failure.
anemia.
decreased blood platelets.
low levels of granulocytes, a type of white blood cell.
low levels of a type of white blood cell called neutrophils.
acute kidney failure.
Valgacel 450mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Valgacel 450mg Tablet. Please consult your doctor.
Valgacel 450mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Valganciclovir is indicated for the induction and maintenance treatment of cytomegalovirus (CMV) retinitis in adult patients with acquired immunodeficiency syndrome (AIDS).
Dicyclomine Dicyclomine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Didanosine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Didanosine.
Swallow it as a whole. Do not chew, crush or break it. Valgacel 450mg Tablet is to be taken with food.
Store below 30°C
If you miss a dose of Valgacel 450mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Valgacel 450mg Tablet is to be taken with food.
Q. What is valganciclovir used for?
Valganciclovir is used for the treatment of cytomegalovirus (CMV) infection of retina (retinitis) in adult patients with acquired immunodeficiency syndrome (AIDS). It is also used for the prevention of CMV infection in patients who have received an organ transplant from a CMV-infected donor
Q. How does valganciclovir work?
After taken orally, valganciclovir gets converted into ganciclovir by liver and intestinal enzymes, which then prevents the growth and spread of cytomegalovirus.
Q. Is valganciclovir cytotoxic?
No, valganciclovir is not cytotoxic
Q. Does valganciclovir cover HSV?
Valganciclovir can also be used for treatment of herpes simplex virus (HSV) infection. Please follow doctor's advice regarding its use
