Manufacturer: Emcure Pharmaceuticals Ltd
Salt Composition : Tacrolimus(5mg)
The amount of Vingraf 5mg Capsule you take and how often you take it depends on the type of transplant you have, your body weight, and what other medicines you are taking. Follow your doctor’s instructions carefully. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Take this medicine regularly to get the maximum benefit and keep taking it, even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ.
Vingraf 5mg Capsule has many potential side effects. It can cause or worsen diabetes and kidney and liver problems. These need urgent medical attention. Other common side effects include nausea, stomach pain, diarrhea, and difficulty sleeping. If the side effects do not go away or get worse, tell your doctor. Vingraf 5mg Capsule lowers your immune system making you susceptible to catching more infections than usual.
Before taking this medicine, tell your doctor if you have kidney, liver, or heart problems, diabetes, or high blood pressure. Also let your doctor know what other medications you are taking, especially for infections, pain, and arthritis. These and others may affect, or be affected by, this medicine. You should limit your exposure to the sun and UV (ultraviolet) light while taking it because immunosuppressants could increase your risk of skin cancer.
Both men and women using this medicine should use effective birth control to prevent pregnancy. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed. Before and during treatment you will need frequent medical tests to monitor your progress, and your blood pressure will need to be checked often.
Tacrolimus bonds to an immunophilin, FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase. The drug inhibits calcium-dependent events, such as interleukin-2 gene transcription, nitric oxide synthase activation, cell degranulation, and apoptosis.
Tacrolimus is completely metabolised prior to elimination. The mean disposition half-life is 12 hours and the total body clearance based on blood concentration is approximately 0.06 L/h/kg.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Vingraf
Diarrhea
Increased glucose level in blood
Increased thirst
Kidney damage
Liver damage
Nausea
Stomach pain
Hypersensitivity.
Polyoxyl 60 hydrogenated castor oil (HCO-60) or other components of the formulation.
Vingraf 5mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Vingraf 5mg Capsule.
Vingraf 5mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Tacrolimus is an immunosuppressive agent used for prophylaxis of organ rejection post-transplant. Tacrolimus use is in combination with one or, most commonly, two other immunosuppressive medications. It has an application as an agent for the prevention or treatment of certain autoimmune diseases.
Some products that may interact with this drug include: aluminum/magnesium antacid, cyclosporine, sirolimus, temsirolimus, ziprasidone, other drugs that may increase the level of potassium in the blood (such as "water pills" including amiloride, spironolactone), other drugs that weaken the immune system
Vingraf 5mg Capsule is to be taken empty stomach.
Store below 30°C
If you miss a dose of Vingraf 5mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Vingraf 5mg Capsule is used to prevent organ rejection in transplant patients.
It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness.
Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
Do not stop taking Vingraf 5mg Capsule without talking to your doctor first.
Take this medicine in the dose and duration as advised by your doctor. Vingraf 5mg Capsule is to be taken empty stomach.
Q. Is Vingraf 5mg Capsule an antibiotic?
Yes, Vingraf 5mg Capsule is a type of antibiotic which belongs to a group of medicines called macrolides. It is mostly used after organ transplantation. This medicine’s immune-suppressing property helps prevent organ rejection after kidney, heart, or liver transplant.
Q. Which vaccines should not be taken while taking Vingraf 5mg Capsule?
You should avoid taking any live vaccines (vaccines that use pathogens that are still alive, but are attenuated, that is, weakened) while taking Vingraf 5mg Capsule. These may include vaccinations for measles, mumps, rubella, BCG (TB vaccine), yellow fever, chicken pox and typhoid. You should also avoid taking polio drops (by mouth) or flu vaccine (through nose).
Q. Who should not take Vingraf 5mg Capsule?
Patients who are allergic to it or have a weak immune system, high blood pressure, and kidney failure should avoid Vingraf 5mg Capsule. This medicine should also be avoided in pregnant or breastfeeding women, and in people who plan to receive any live vaccines (e.g. MMR vaccine).
Q. What should I tell my doctor before taking Vingraf 5mg Capsule?
Inform your doctor if you are pregnant, have allergies, long-term infection, high blood sugar, or high blood pressure. You should also inform your doctor if you have high blood potassium levels or a weakened immune system. Tell your doctor if you have a history of any medication, have recently received, or are scheduled to receive a live vaccine.
