Manufacturer: Zydus Cadila
Salt Composition : Ambrisentan(10mg)
Zambri 10mg Tablet may be taken with or without food but, it is better to take it in a dose and duration as advised by the doctor. In case, you have missed any dose than it is better to take another one as soon as you remember it.
Dizziness may occur as its side effect, so do not drive or do anything that requires mental focus. You may also have other side effects like, headache, palpitations, breathlessness, runny nose, feeling sick, diarrhea or fatigue. Let your doctor know if any of these side effects bothers you or persists for a longer duration.
Zambri 10Mg Tablet is a medication used to treat pulmonary hypertension in patients of WHO class II or WHO class III. It is an endothelin receptor antagonist that blocks certain substances present in the lungs, which in turn helps decrease the blood pressure inside the lungs.
Pharmacokinetics were evaluated in sixteen children treated with ambrisentan from 2.5 mg to 10.0 mg; the mean peak plasma concentration was 738 ± 452 ng/ml, mean time to peak plasma concentration was 3.2 ± 2.1 hours, and mean area under the curve plasma concentration was 6657 ± 4246 ng·hour/ml.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zambri
Sinus inflammation
Nasal congestion (stuffy nose)
Peripheral edema
Flushing (sense of warmth in the face, ears, neck and trunk)
anemia.
chronic heart failure.
a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis.
severe liver disease.
visible water retention.
abnormal liver function tests.
pregnancy.
a patient who is producing milk and breastfeeding.
Zambri 10mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
It is not known whether it is safe to consume alcohol with Zambri 10mg Tablet. Please consult your doctor.
Information regarding the use of Zambri 10mg Tablet during breastfeeding is not available. Please consult your doctor.
Ambrisentan is indicated for treatment of idiopathic ('primary') pulmonary arterial hypertension (IPAH) and pulmonary arterial hypertension (PAH) associated with connective tissue disease in patients with WHO functional class II or III symptoms.
Integrate drug-drug interactions
Amlodipine Amlodipine may increase the hypotensive activities of Ambrisentan.
Amoxapine Amoxapine may decrease the antihypertensive activities of Ambrisentan.
Amphetamine Amphetamine may decrease the antihypertensive activities of Ambrisentan.
Store below 30°C
If you miss a dose of Zambri 10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Your doctor has prescribed Zambri 10mg Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Zambri 10mg Tablet affects you.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Zambri 10mg Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zambri 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. Can Zambri 10mg Tablet cause liver problems?
Yes, Zambri 10mg Tablet commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.
Q. How should Zambri 10mg Tablet be taken?
Usually, the doctors advise to take one dose of Zambri 10mg Tablet. You can take it with or without food at any time of the day but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.
Q. Can I stop taking Zambri 10mg Tablet on my own?
No, you should not stop taking Zambri 10mg Tablet without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.
Q. What is the most important thing that I should know about Zambri 10mg Tablet?
Zambri 10mg Tablet may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Zambri 10mg Tablet. Additionally, during treatment with Zambri 10mg Tablet you should use two reliable methods of contraception to ensure that you do not get pregnant.
