Manufacturer: Pfizer Ltd
Salt Composition : Idarubicin(5mg)
Zavedos 5mg Injection is given as an injection under the supervision of a doctor, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include vomiting, nausea, infection, hair loss, and fever. This medicine may reduce the number of blood cells in your blood(decrease red blood and white blood cells), thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Zavedos 5mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer cells. It also forms harmful chemicals (free radicals) which cause DNA damage. This slows the growth of cancer cells and eventually kills them.
The pharmacokinetics of idarubicin follow a 2- or 3-compartment plasma disappearance with half-life (t1/2) values of 13 min, 2.4h and 16h, clearance approximately 60 L/h/m2 and volume of distribution at steady-state of 1,500 L/m2.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zavedos
Vomiting
Nausea
Infection
Hair loss
Fever
Increased liver enzymes
Peripheral neuropathy (tingling and numbness of feet and hand)
Stomatitis (Inflammation of the mouth)
Bleeding
Myelosuppression
Seizure
Contraindicated: Adenovirus Vaccine, Live; BCG Live Intravesical; Influenza Nasal Vaccine, Live; Measles/Mumps/Rubella Vaccine, Live; Rotavirus Vaccine, Live; Smallpox Vaccine (Live Vaccinia Virus); Typhoid Vaccine, Live; Varicella Vaccine, Live; Yellow Fever Vaccine, Live; Zoster Vaccine, Live.
Zavedos 5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Zavedos 5mg Injection. Please consult your doctor.
Zavedos 5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
(idarubicin hydrochloride for injection, USP) in combination with other approved antileukemic drugs is indicated for the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
Drug-Drug Interactions: No interactions found.
Drug-Food Interactions: IDARUBICIN may interact with alcohol. Therefore, avoid alcohol consumption with IDARUBICIN as it may increase the risk of liver damage.
Drug-Disease Interactions: Inform your doctor if you have liver or kidney disease before starting treatment with IDARUBICIN.
Store below 30°C
Consult a doctor before taking any medicines.
Consult a doctor before taking any medicines.
Zavedos 5mg Injection is given as an injection under the supervision of a doctor only.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your blood uric level, liver function, blood cell count in your blood.
You may also be checked for heart functioning timely while on the treatment with this medicine.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. Is Zavedos 5mg Injection a vesicant?
Zavedos 5mg Injection can cause inflammation of the vein in which it is administered; and irritation and ulceration of surrounding tissue, if leakage occurs at the site of intravenous administration.
Q. What is Zavedos 5mg Injection used for?
Zavedos 5mg Injection is used in the treatment of acute myeloid leukaemia (a type of cancer of the white blood cells) in combination with other medications and breast cancer in advance stage after failure with other medications.
Q. How does Zavedos 5mg Injection work?
Zavedos 5mg Injection acts by inhibiting the growth of cancer cells.
