Manufacturer: Wockhardt Ltd
Salt Composition : Levocetirizine(2.5mg/5ml), Phenylephrine(5mg/5ml), Paracetamol(250mg/5ml)
Bottle of 60ml Syrup
(Inclusive of all taxes)
Zedex-P Cold Syrup can be taken with or without food. The dose required by you may vary depending on what you are taking it for. This medicine is usually taken in the evening, but follow the advice of your doctor on how to take it. You may need this medicine only on days you have symptoms, but if you are taking it to prevent the symptoms then you should take it regularly. If you miss doses or stop taking it earlier than advised, your symptoms may come back.This medicine is generally very safe. The most common side effects include feeling sleepy or dizzy, dry mouth, fatigue, and headache. These are usually mild and go away after a couple of days as your body adjusts to it. Consult your doctor if any of the side effects persist or worry you.
Zedex-P syrup works by the combined action of its components.Chlorpheniramine maleate acts by blocking the action of histamine a natural substance produced by the body during an allergic reaction and improves allergic symptoms like sneezing, watery eyes, throat irritation.Phenylephrine acts as a vasoconstrictor, it shrinks or constricts the blood vessels in the nasal passage and improves congestion.Paracetamol (also called Acetaminophen) works by interfering with the production of a chemical called prostaglandins, which is responsible for the fever, swelling and sensation of pain. It also acts on the area of the brain which is responsible for controlling body temperature.Sodium citrate is a mucolytic agent which decreases the consistency of this mucous and makes it thin. Thus, these agents help to remove this mucous from the windpipe and lungs and improves the patient’s condition.Menthol provides a cooling effect on the throat and sensory nerves.
Levocetirizine exhibited linear pharmacokinetics over the therapeutic dose range in adult healthy subjects. Levocetirizine is rapidly and extensively absorbed following oral administration. In adults, peak plasma concentrations are achieved 0.9 hour after administration of the oral tablet.Oral phenylephrine is extensively metabolized by monoamine oxidase, an enzyme that is present on the mitochondrial membrane of cells throughout the body. Compared to intravenous pseudoephedrine, phenylephrine has a reduced and variable bioavailability; only up to 38%.It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zedex-P Cold
Sleepiness
Fatigue
Dryness in mouth
Headache
Vomiting
Nasopharyngitis (inflammation of the throat and nasal passages)
Nausea
High blood pressure
Arrhythmia (irregular heartbeats)
Blurred vision
Breathlessness
Itching
Restlessness
Reflex bradycardia
Excitation
Epigastric pain
Neck pain
Tremors
Hypertensive crisis
Eye pain
Stinging in the eyes
Photophobia
Conjunctival sensitivity
Preterm and low birth weight infants
Fainting
Myocardial infarction
Subarachnoid hemorrhage
Insomnia (difficulty in sleeping)
Constipation
Hypersensitivity to Zedex P Cold Syrup is a contraindication. In addition, Zedex P Cold Syrup should not be used if you have the following conditions:
Concomitant use with a monoamine oxidase inhibitor
Hypersensitivity
Hyperthyroidism
Seizures
Use within 2 weeks of discontinuing a monoamine oxidase inhibitor
Zedex-P Cold Syrup may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Zedex-P Cold Syrup.
Zedex-P Cold Syrup is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use with caution
Below 9years: Contraindicated
Levocetirizine + Phenylephrine + Paracetamol is relieves common cold symptoms. Levocetirizine is an antiallergic which blocks histamine (a chemical messenger) to relieve allergy symptoms like runny nose, watery eyes and sneezing. Phenylephrine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain and fever.
If you use other drugs or over the counter products at the same time, the effects of Zedex P Cold Syrup may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Zedex P Cold Syrup may interact with the following drugs and products:
Alcohol
Amiodarone
Anisindione
Cough and cold medicines
Decongestants
Dicumarol
Digoxin
Haloperidol
High blood pressure medicines
Monoamine oxidase inhibitors
Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Zedex-P Cold Syrup may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Zedex-P Cold Syrup, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Levocetirizine
Your doctor has prescribed Levocetirizine to help relieve allergy symptoms such as itching, swelling, and rashes.
As compared to other similar medications, it is much less likely to make you feel sleepy.
Be cautious while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
Do not drink alcohol while taking this medication as it may cause increased sleepiness.
Stop taking Levocetirizine at least three days before taking an allergy test as it can affect the test results.
Phenylephrine
Oral phenylephrine should be taken with food
Phenylephrine can make you restless, so don't take it too close to bedtime
Do not use this medicine without doctor's advice if you are pregnant or breast feeding
Smoking may worsen the effect; therefore use of tobacco should be avoided.
Paracetamol
Paracetamol should be taken with food or milk to prevent upset stomach.
Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
Do not take indigestion remedies (antacids) within 2 hours of taking Paracetamol.
Avoid consuming alcohol while taking this medicine as it can increase your risk of stomach problems.
Inform your doctor if you have liver disease as your dose may need to be adjusted.
Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Zedex-P Cold Syrup may be taken with or without food, but it is better to take it at a fixed time.
Levocetirizine
Q. Is Levocetirizine a steroid? What is it used for?
No, Levocetirizine is not a steroid. It is an anti-allergic medication which is used to relieve the symptoms of allergy. It relieves runny nose, sneezing and redness, itching and watering of the eyes caused by hay fever or seasonal allergies. It also relieves similar symptoms caused due to allergies to substances, such as dust mites, animal dander and mold. Additionally, it is helpful in treating symptoms of hives, including itching and rash.
Q. Does Levocetirizine make you tired and drowsy?
Yes, Levocetirizine can make you feel tired, sleepy and weak. If you have these symptoms, avoid driving or operating heavy machinery. Consult your doctor if not sure.
Q. How long does it take for Levocetirizine to work?
Levocetirizine starts working and showing improvement within an hour of taking it. However, it may take a little longer to notice the full benefits.
Q. Can I take Levocetirizine and Fexofenadine together?
Sometimes the doctor may advise you to take two different antihistamines together if you are being treated for a severe itchy rash. If you are taking Levocetirizine during the daytime, your doctor may prescribe another antihistamine for the night which causes sleepiness, especially if the itch makes it difficult for you to sleep.
Q. Is it safe to take Levocetirizine for a long time?
Levocetirizine is safe if used as prescribed by your doctor. Moreover, it is unlikely to harm you if you take it for a long time. But, it is best to take Levocetirizine for only as long as you need it.
Q. For how long should I continue Levocetirizine?
The duration for which the medicine needs to be taken depends on the problem being treated. For instance, if you are taking it for an insect bite, you may need it for a day or two. While, if you are taking it to prevent symptoms of chronic allergic rhinitis (inflammation of nose) or chronic urticaria, you may need to take Levocetirizine for a longer time. Talk to your doctor if you are unsure about the duration of using Levocetirizine
Phenylephrine
Q. Is it safe to use Phenylephrine?
Yes, Phenylephrine is safe for most of the patients. However, in some patients, it may cause side effects like nausea, vomiting, headache, fatigue, dizziness, dryness in the mouth, sleepiness and allergic reaction. If you experience any persistent problem while taking this medication, inform your doctor as soon as possible.
Q. Can the use of Phenylephrine cause dizziness?
Yes, the use of Phenylephrine can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for sometime and resume once you feel better. Do not drive or use any machines. Consult your doctor if the side effect persist or worsen.
Q. Can the use of Phenylephrine cause nausea and vomiting?
Yes, the use of Phenylephrine can cause nausea and vomiting. To avoid nausea one can take Phenylephrine with milk, food or with antacids. If vomiting occurs, drink plenty of water or other fluids. Talk to your doctor if vomiting persists. You should let your doctor know if you are unable to drink water and there are signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Avoid taking fatty or fried foods along with this medication. Do not take any other medicine without consulting your doctor.
Paracetamol
Q. What if I vomit after taking Paracetamol?
If you vomit in less than 30 minutes after having a dose of Paracetamol tablets or syrup, retake the same dose again. If you vomit after 30 minutes of a dose, you do not need to take another one until the next standard dose.
Q. When will I feel better after taking the Paracetamol?
Usually, you will start feeling better after about half an hour of taking a Paracetamol.
Q. How often can I take the Paracetamol?
You should only take four doses of Paracetamol in 24 hours. There should be a gap of at least 4 hours between two doses. Do not take Paracetamol for more than 3 days without consulting a doctor first.
Q. Does Paracetamol make babies sleepy?
No, Paracetamol does not make babies sleepy. It is a pain-relieving medicine that is also used to control high fever.
Q. Is Paracetamol safe for children?
Paracetamol is considered safe for children only when used as directed by the doctor.
Q. Is Paracetamol an antibiotic?
No, Paracetamol is not an antibiotic. It works as a painkiller and fever-reducing medicine.
Q. Can I take Paracetamol and ibuprofen together?
Ibuprofen and Paracetamol are safe medicines, but both should not be used together. Consult your doctor if you are not sure.
Q. How long does a Paracetamol take to work?
Paracetamol takes around 30-45 min to start working and show its effects. It is advised to take this medicine for the duration suggested by the doctor. Consult your doctor if you experience any bothersome side effects.
Q. What are the serious side effects of taking an excess of the Paracetamol?
Overdose of Paracetamole may cause severe life-threatening liver injury. Taking more than the prescribed dose may also cause kidney injury, decreased platelet count, and even coma. Early symptoms of an overdose include nausea, vomiting, and general tiredness. Immediately consult a doctor or reach an emergency in case of a suspected overdose.
