Manufacturer: Lupin Ltd
Salt Composition : Diphenhydramine
Bottle of 100ml Syrup
(Inclusive of all taxes)
Zendryl Syrup is best taken before a meal or at bedtime. Take it exactly as prescribed by your doctor. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Take it for as long as it is prescribed for you. In case, you have missed any doses, take the next dose as soon as you remember it. However, you should never take a double dose.
Dizziness and drowsiness are the most common side effect of this medicine. Avoid driving or attention-seeking activities while on treatment with this medicine. In some cases, it may cause also dryness of mouth. To prevent dry mouth, drink more water and maintain good oral hygiene.
Before taking this medicine, let your doctor know if you have glaucoma or have any gastro-related issues or have asthma. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.
Zendryl Syrup is a combination medicine containing diphenhydramine, ammonium chloride, and sodium citrate which helps in reducing cough with phlegm.
Diphenhydramine blocks the effects of allergic chemicals and provides relief from allergic symptoms such as running nose and watery eyes.
Ammonium chloride is an expectorant agent which increases the water content in the windpipe. Therefore, cough associated with thick mucus (phlegm) is relieved by making the mucus easy to expel.
Sodium citrate is a mucolytic agent which decreases the consistency of this mucus and makes it thin. Thus, these agents help to remove this mucus from the windpipe and lungs and improve the patient’s condition.
Oral bioavailability of diphenhydramine is in the range of 40% to 60%, and peak plasma concentration occurs about 2 to 3 hours after administration. The primary route of metabolism is two successive demethylations of the tertiary amine.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zendryl
Dizziness
Drowsiness
Dryness in mouth
Documented hypersensitivity to diphenhydramine
Premature infants and neonates
Breastfeeding mothers
Pregnancy Category B - used only if clearly needed
Diphenhydramine has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers)
Monoamine oxidase A inhibitors prolong and intensify the anticholinergic effects of antihistamines
Zendryl Syrup is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Zendryl Syrup may cause excessive drowsiness with alcohol.
Zendryl Syrup is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Larger doses or prolonged use of Zendryl Syrup may cause sleepiness and other effects in the baby
Use with caution
Below 9years: Contraindicated
Diphenhydramine, which is available as an over-the-counter medication, is a first-generation antihistamine that is used in a variety of conditions to treat and prevent dystonias, insomnia, pruritis, urticaria, vertigo, and motion sickness.
This medicine may interact with other anti-allergic drugs (cetirizine), sleeping pills (zolpidem), anti-depressants (escitalopram, alprazolam), pain-killer (tramadol, acetaminophen), and cough suppressants (dextromethorphan).
Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Zendryl Syrup may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Zendryl Syrup, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
Avoid driving or operating dangerous machinery as it may decrease alertness.
Avoid consuming alcohol when taking the Zendryl Syrup, as it may cause excessive sleepiness or drowsiness.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Zendryl Syrup may be taken with or without food, but it is better to take it at a fixed time.
