Manufacturer: FDC Ltd
Salt Composition : Glimepiride(2mg), Metformin(500mg)
Strip of 10 Tablet Pr
(Inclusive of all taxes)
Ziglim-M 2 Tablet PR should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Ziglim-M 2 Tablet PR is a combination of two antidiabetic medicines: Glimepiride and Metformin. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose.
Glimepiride is completely metabolized by oxidative biotransformation after either an IV or oral dose. The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2). Cytochrome P450 2C9 has been shown to be involved in the biotransformation of glimepiride to M1.Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ziglim-M
Hypoglycemia (low blood glucose level)
Headache
Nausea
Diarrhea
Flatulence
Hypersensitivity to Ziglim-M 2 PR Tablet is a contraindication. In addition, Ziglim-M 2 PR Tablet should not be used if you have the following conditions:
Acute myocardial infarction
Cardiovascular collapse
Diabetic ketoacidosis
Hypersensitivity
Hypersensitivity to sulfonamide derivatives
Hypersensitivity to this drug
Renal disease
Septicemia
Ziglim-M 2 Tablet PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is unsafe to consume alcohol with Ziglim-M 2 Tablet PR.
Ziglim-M 2 Tablet PR is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Use with caution
Below 9years: Contraindicated
GLIMEPIRIDE+METFORMIN belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose.
If you use other drugs or over the counter products at the same time, the effects of Ziglim-M 2 PR Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Ziglim-M 2 PR Tablet may interact with the following drugs and products:
Albuterol
Alcohol
Anabolic steroids
Androgens
Angiotensin converting enzyme inhibitors
Anti-diabetic drugs
Atypical antipsychotic medications
Barbiturates
Beta blockers
Chloramphenicol
check the label for directions before use. Ziglim-M 2 Tablet PR is to be taken with food.
Store below 30°C
If you miss a dose of Ziglim-M 2 Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines.
You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Ziglim-M 2 Tablet PR.
Take it with food to lower your chance of having an upset stomach.
Monitor your blood sugar level regularly while you are taking this medicine.
It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Ziglim-M 2 Tablet PR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Use it as advised by your doctor or check the label for directions before use. Ziglim-M 2 Tablet PR is to be taken with food.
Q. What are the recommended storage conditions for Ziglim-M 2 Tablet PR?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can the use of Ziglim-M 2 Tablet PR lead to lactic acidosis?
Yes, the use of Ziglim-M 2 Tablet PR can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is considered to be harmful for patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Ziglim-M 2 Tablet PR and consult your doctor immediately.
Q. What is Ziglim-M 2 Tablet PR?
Ziglim-M 2 Tablet PR is a combination of two medicines: Glimepiride and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.
Q. What are the possible side effects of Ziglim-M 2 Tablet PR?
The use of Ziglim-M 2 Tablet PR is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.
Q. Can the use of Ziglim-M 2 Tablet PR lead to Vitamin B12 deficiency?
Yes, the use of Ziglim-M 2 Tablet PR can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can experience tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.
Q. Can the use of Ziglim-M 2 Tablet PR cause hypoglycemia?
Yes, the use of Ziglim-M 2 Tablet PR can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.
Q. Is it safe to take alcohol while I am also taking Ziglim-M 2 Tablet PR?
No, it is not safe to take Ziglim-M 2 Tablet PR along with alcohol, as it may lower your blood sugar levels and lead to hypoglycemia. It can also increase the chances of lactic acidosis.
