Manufacturer: Elder Pharmaceuticals Ltd
Salt Composition : Amikacin(500mg)
Vial of 2ml Injection
(Inclusive of all taxes)
Zoftamic 500mg Injection works by stopping the growth of bacteria. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional and should not be self-administered. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.
Zoftamic Injection alters the protein synthesis (responsible for cell multiplication) of the bacteria, stops the growth of bacteria and results in cell death.
The plasma elimination half-life of amikacin is usually 2-3 hours in adults with normal renal function and is reported to range from 30-86 hours in adults with severe renal impairment. The mean serum clearance rate is about 100 mL/min and the renal clearance rate is 94 mL/min in subjects with normal renal function.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zoftamic
Increased blood urea
Injection site reactions (pain, swelling, redness)
diarrhea from an infection with Clostridium difficile bacteria.
low amount of calcium in the blood.
dehydration.
a type of movement disorder called parkinsonism.
myasthenia gravis, a skeletal muscle disorder.
ringing in the ears.
disorder of nerve that controls hearing and balance.
Zoftamic 500mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Consuming alcohol with Zoftamic 500mg Injection does not cause any harmful side effects.
Zoftamic 500mg Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Amikacin sulfate injection is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and ...
When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Zoftamic Injection may interact with cisplatin, ciclosporin, tacrolimus, which are used to treat cancer. Using Zoftamic with cisplatin, ciclosporin or tacrolimus may increase the risk of additive effects. The use of Zoftamic with these agents should be avoided. If required, patients should be monitored carefully.
There may be an interaction of Zoftamic with beta-lactam antibotics such as penicillin, cephalosporins, which are used to treat bacterial infections. Using Zoftamic parenterally with cephalosporins may increase the risk of drug-induced harmful effects on the kidney and increases the creatinine levels in the blood. In addition, when aminoglycosides or penicillins are given by a separate route, it may decrease the activity of the medicine in the blood.
Zoftamic Injection interacts with potent diuretics (ethacrynic acid or furosemide), which are used to increase the production of urine. Using Zoftamic sulphate injection with diuretics may cause harmful effect to the ear. In addition, when diuretics are taken intravenously (into a vein), it may enhance the harmful effect of aminoglycoside by altering the level of antibiotic in the blood and tissue. The use of Zoftamic sulphate injection with diuretics should be avoided.
Special instructions need to be followed while taking this medicine along with amphotericin B, vancomycin, clindamycine, paromomycin, cephaloridine bacitracin, viomycin, colistin, polymyxin B, or other aminoglycosides which are used to treat bacterial infection. The use of Zoftamic with these medicines increases the risk of additive effects. The use of Zoftamic with these agents should be avoided.
Your doctor's guidelines may need to be followed while taking this medicine along with bisphosphonates, which are used to treat the loss of bone density. When Zoftamic is used with bisphosphonates, it may decrease the calcium level in the blood.
Zoftamic Injection may interact with platinum compounds, which are used to treat cancer. Using Zoftamic with platinum compounds may increase the risk of a drug-induced harmful effect on the kidney and ears.
There may be an interaction of Zoftamic with thiamine (vitamin B1) which plays an important role in glucose metabolism, nerve, muscle, and heart functioning in the body. Thiamine (vitamin B1) may be destroyed by the reactive chemical part (sodium bisulfite) of Zoftamic.
Zoftamic Injection interacts with anesthetics or muscle-relaxing drugs (including ether, halothane, d-tubocurarine, succinylcholine, suxamethonium and decamethonium) which are used to induce paralysis and anesthesia. Using Zoftamic intraperitoneally (inserted into the stomach) with anesthetics or muscle-relaxing drugs may cause neuromuscular blockade which may lead to slow and ineffective breathing. The intraperitoneal (inserted into the abdominal cavity) use of Zoftamic with these medicines is not recommended.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Zoftamic 500mg Injection, please consult your doctor.
Consult a doctor before taking any medicines.
Your doctor has prescribed Zoftamic 500mg Injection to cure your infection and improve your symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle.
Your doctor may get regular blood, urine, or hearing tests while you are on this medication.
Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Discontinue Zoftamic 500mg Injection and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. For how long can Zoftamic 500mg Injection be taken?
The usual course of treatment with Zoftamic 500mg Injection is about 7 to 10 days. However, your doctor will decide your dose depending on the condition you are being treated for. Continue taking Zoftamic 500mg Injection in the dose and duration prescribed by the doctor to get maximum benefit. Do not alter the dose of the medicine on your own, consult your doctor first.
Q. Is Zoftamic 500mg Injection safe?
Zoftamic 500mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Q. How is Zoftamic 500mg Injection administered?
Zoftamic 500mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get the maximum benefit from Zoftamic 500mg Injection.
Q. Can I take a higher than the recommended dose of this medicine?
No, Zoftamic 500mg Injection should be taken in the recommended dose only. Overdose of Zoftamic 500mg Injection can increase the risks of side effects. If you experience an increase in the severity of your symptoms during the treatment, please consult your doctor for re-evaluation.
