Zoldro 4mg (Injection)

Manufacturer: United Biotech Pvt Ltd

Salt Composition : Zoledronic acid(4mg)

Prescription
Prescription Required: Consult the Doctor & Get Your ePrescription

Zoldro 4mg Injection is given by a doctor or nurse. How much you are given, and how often, will be decided by your doctor. It may just be a single injection or you may need regular injections depending upon your underlying condition. Your doctor will ask you to drink plenty of water before the injection, to avoid getting dehydrated. It may take several days to get the full benefit of this drug. Zoldro 4mg Injection is only part of a treatment program that may also include changes to your diet and taking calcium and vitamin supplements.


Basic Information

Mechanism Of Action

Zoldro 4mg Injection works by increasing the density of the bones which helps in preventing osteoporosis. In addition to that, it helps to treat high calcium levels in the blood caused due to secondary bone cancer. Also, it is helpful in treating metastasis of bone which is caused due to breast cancer.


Pharmacokinets

Zoledronic plasma disposition was multiphasic, with half-lives of 0.2 and 1.4 hours representing an early, rapid decline of concentrations from the end-of- infusion Cmax to < 1% of Cmax at 24 hours postdose and half-lives of 39 and 4526 hours describing subsequent phases of very low.

Side Effects

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zoldro

Headache

Back pain

Musculoskeletal (bone, muscle or joint) pain

Heartburn

Diarrhea

Nausea

Breathlessness

Fatigue

Constipation

Bone pain

Vomiting

Fever

Anemia (low number of red blood cells)

Contra Indications

low amount of magnesium in the blood

low amount of phosphate in the blood

low amount of calcium in the blood

dehydration

inflammation of the tissues surrounding a tooth

acute kidney failure

joint pain

muscle pain

pregnancy

a patient who is producing milk and breastfeeding

portions of the jaw bone to die from lack of blood circulation

invasive dental procedure

chronic kidney disease stage 4 (severe)

chronic kidney disease stage 5 (failure)

kidney disease with likely reduction in kidney function

an unusual and spontaneous bone break in the upper leg

Pregnancy Related Information

Zoldro 4mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.


Product And Alcohol Interaction

Caution is advised when consuming alcohol with Zoldro 4mg Injection. Please consult your doctor.


Breast Feeding Related Information

Zoldro 4mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.


Children Related Information

Use with caution

Below 9years: Contraindicated


Indications

Zoledronic Acid Injection is indicated for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. Prostate cancer should have progressed after treatment with at least one hormonal therapy.

Interactions

aminoglycosides (e.g., gentamicin, tobramycin)

calcitonin.

diuretics (water pills; e.g., hydrochlorothiazide, furosemide)

non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)

phosphate supplements.

Typical Dosage

Kindly do not self administer.

Storage Requirements

Store below 25°C


Effects Of Missed Dosage

If you miss a dose of Zoldro 4mg Injection. Please consult your doctor.


Effects Of Overdose

Consult a doctor before taking any medicines.

Expert Advice

You have been prescribed Zoldro 4mg Injection for the treatment of osteoporosis.

It may also be used to treat high blood calcium levels (hypercalcemia) or bone damage and pain that may occur with cancer.

It is given by injection into a vein, usually over at least 15 minutes or as directed by your doctor.

Drink plenty of fluids to prevent dehydration and kidney damage.

It can lower the level of calcium in the blood. Take calcium and vitamin D supplements as suggested by your doctor.

You may develop fever or flu like symptoms, such as chills, tiredness and weakness. These are usually temporary and should go away after a few days. You may take a pain reliever/fever reducer to prevent or treat these symptoms.

Zoldro 4mg Injection may cause a rare condition called osteonecrosis of the jaw. Have regular dental check-ups and inform your doctor if you develop sudden pain in your jaw.

Your doctor will monitor your response to Zoldro 4mg Injection by testing your bone mineral density (BMD). This is usually done every 1-3 years.

Do not take Zoldro 4mg Injection if you are pregnant or breastfeeding.

How To Use

Your doctor or nurse will give you this medicine. Kindly do not self administer.


FAQs

Q. What is Zoldro 4mg Injection? What is it used for?

Zoldro 4mg Injection belongs to a class of medicines called bisphosphonates that prevents abnormal breakdown of the bones. Zoldro 4mg Injection is used to prevent and treat osteoporosis and fractures in people with metastatic cancer (a cancer which spreads to newer areas of the body). It may also be used to treat hypercalcemia (elevated blood calcium levels).

Q. How does Zoldro 4mg Injection work?

Zoldro 4mg Injection works by increasing the density of the bones which helps in preventing osteoporosis. In addition to that, it helps to treat high calcium levels in the blood caused due to secondary bone cancer. Also, it is helpful in treating metastasis of bone which is caused due to breast cancer.

Q. How long should I take Zoldro 4mg Injection?

Zoldro 4mg Injection should be taken in the dose and duration advised by your doctor. The medicine takes around 6 month to show its maximum benefits on bones. However, in some cases, the doctor may suggest Zoldro 4mg Injection for a longer duration. The exact duration will depend on the condition you are being treated for.

Q. How is Zoldro 4mg Injection administered?

Zoldro 4mg Injection should be administered by a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Zoldro 4mg Injection.

Q. Why can you not lie down after taking Zoldro 4mg Injection?

One should not lie down after taking Zoldro 4mg Injection as there is a possibility that the medication might come back up into the esophagus (food pipe). Due to this the esophagus may also get damaged. Staying upright will help the medicine to settle down quickly in your stomach and prevent side effects like heartburn and pain.

Q. Is Zoldro 4mg Injection safe?

Zoldro 4mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Q. What other lifestyle changes should I make?

To get maximum benefit from Zoldro 4mg Injection, there are certain lifestyle changes that you must adhere to. Include some calcium or Vitamin D rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight which in turn improve bone health.